Design, development and evaluation of registry software for upper limb disabilities.

Upper limb disabilities, if not managed, controlled and treated, significantly affect the physical and mental condition, daily activities and quality of life. Registries can help control and manage and even treat these disabilities by collecting clinical-management data of upper limb disabilities. Therefore, the aim of this study is to design, develop and evaluate a registry system for upper limb disabilities in terms of usability.

Investigating the resilience of kidneys in rats exposed to chronic partial sleep deprivation and circadian rhythm disruption as disruptive interventions.

Sleep is a vital biological function that significantly influences overall health. While sleep deprivation (SD) and circadian rhythm disruption are known to negatively impact various organs, their specific effects on kidney function remain understudied. This study aimed to investigate the impact of chronic partial sleep deprivation and circadian rhythm disruption on renal function in rats, providing insights into the relationship between sleep disturbances and kidney health.

Echinococcus granulosus sensu lato control measures: a specific focus on vaccines for both definitive and intermediate hosts.

Echinococcosis, a neglected zoonotic disease caused by Echinococcus tapeworms, presents significant public health challenges worldwide. Cystic and alveolar echinococcosis has substantial health and economic impacts, necessitating effective prevention and control strategies. The present review provides a framework to expand our knowledge regarding key components of echinococcosis prevention and control, including phases, options, targets and available tools as well as current gaps and challenges in the field.

Fasting recovers age-related hypertension in the rats: reset of renal renin-angiotensin system components and klotho.

Background: The renal renin-angiotensin system (RAS) plays a vital part in the control of blood pressure and is known to be affected by aging. This study aimed to investigate the effects of intermittent fasting on age-related hypertension and the expression of local renal RAS components.

Methods: The Wistar rats were categorized into three main age groups (young, middle aged, and elderly) and three dietary treatment models, including ad libitum feeding (AL), every other day fasting (EOD), and one day per week of fasting (FW).

Effects of Enriched Environment on Barrel Cortex and Hippocampus Function following Somatosensory Damage in Rat.

Objectives: This study investigated the effects of environmental enrichment (EE) on the behavior and histological alterations of rats with barrel cortex damage.

Methods: Forty-eight adult male rats were divided into Control (Ctrl), Lesion, Lesion+EE.S (Lesion+Standard Enriched Environment, and Lesion+EE.

Investigating ethical considerations in the communication network of married women undergone hysterectomy: instrumentation of a questionnaire.

Introduction: Considering the importance of complying medical and general ethics and the lack of a study on determining ethical considerations in the communication network of women undergoing hysterectomy surgery, this study aimed to present these aspects in the patients' lives by a standard researcher-made instrument.

Method: This mixed method analysis (exploratory sequential mixed methods design was conducted in the whole of 2020 to create the "ethical considerations in communication network of women undergone hysterectomy" questionnaire and investigate its psychometric properties. A researched-made instrument was validated and its psychometric properties were checked among 218 women by confirmatory factor analysis (CFA).

Up-Regulation of miR-625-5p Correlates with Suppressed Sox2, Increased Apoptosis, and Cell Cycle Arrest via The PI3K/AKT Signalling Pathway in Acute Myeloid Leukaemia.

Up-regulation of the microRNA-625 and abnormal expression of the Sox2 gene have been studied and seen in several tumors. Few reports have also shown the aberrant expression of miR-625 and Sox2 expression in various cancers. Several studies have also confirmed that phosphatidylinositol 3' -kinase /protein kinase B pathways regulate hematological malignancies, including Acute Myeloid Leukemia (AML).

Gout: global epidemiology, risk factors, comorbidities and complications: a narrative review.

Background: Gout is one of the oldest known diseases and the most common form of inflammatory arthritis. The established risk factors for gout include hyperuricemia, chronic renal disease, genetic, alcohol consumption, dietary factors, diuretic use, hypertension, obesity, and metabolic syndrome. Patients with gout have an increased risk of all-cause mortality, particularly from cardiovascular disease, cancer, and infectious diseases.

Methodological Challenges in Randomized Controlled Trials of mHealth Interventions: Cross-Sectional Survey Study and Consensus-Based Recommendations.

Background: Mobile health (mHealth) refers to using mobile communication devices such as smartphones to support health, health care, and public health. mHealth interventions have their own nature and characteristics that distinguish them from traditional health care interventions, including drug interventions. Thus, randomized controlled trials (RCTs) of mHealth interventions present specific methodological challenges.

Barriers and facilitators of HIV partner status notification in low- and lower-middle-income countries: A mixed-methods systematic review.

Background: The uptake of HIV partner status notification remains limited in low- and lower-middle-income countries. This mixed-methods systematic review aims to summarize the barriers and facilitators of HIV partner status notification in these settings.

Methods: We searched PubMed, Embase, CINAHL, PsychINFO, Scopus, and Web of Science from January 01, 2000, to August 31, 2023, for empirical qualitative and quantitative studies.

Cumulative incidence and treatment effectiveness of low bone mineral density among people living with HIV in Iran (2021-2023).

Background: The introduction of antiretroviral therapy (ART) has significantly improved the life expectancy of people living with HIV (PLHIV), leading to an increased prevalence of age-related comorbidities such as osteoporosis. This study investigates the incidence and characteristics of low bone mineral density (BMD) and the treatment effectiveness of low BMD participants among PLHIV in Kerman, Iran.

Methods: A longitudinal study utilized dual-energy X-ray absorptiometry (DEXA) to screen 94 PLHIV in Kerman, Iran, for low BMD.

In vitro ultrastructure and biodegradation of activated plasma albumin gel derived from human samples: A prospective observational study.

Background: In soft tissue regeneration, the clinical efficacy of fibrin membranes has been a pressing concern. The key to this efficacy lies in the stability of membrane and its controlled absorption. Human serum albumin, with its influence on the formation and stability of fibrin networks, could hold the key to developing a more stable alternative.

Comparison between intratympanic injection of dexamethasone and methylprednisolone in idiopathic sudden sensorineural hearing loss: A randomized clinical trial.

Objective: To compare the hearing outcomes of patients with idiopathic sudden sensorineural hearing loss after intratympanic (IT) injection of methylprednisolone and dexamethasone.

Study Design: Randomized case-controlled clinical trial.

Methods: Seventy-five patients diagnosed with idiopathic sensorineural hearing loss were randomly divided into two groups based on therapy.

The activation of the G-protein-coupled estrogen receptor promotes the aggressiveness of MDA-MB231 cells by targeting the IRE1α/TXNIP pathway.

Background And Purpose: This study investigated modulating the G protein-coupled estrogen receptor (GPER) on the IRElα/TXNIP pathway and its role in drug resistance in MDA-MB231 cells.

Experimental Approach: To determine the optimal concentrations of G and 4-hydroxytamoxifen (TAM), GPER expression and ERK1/2 phosphorylation were analyzed using qRT-PCR and western blotting, respectively. Cells were treated with individual concentrations of G (1000 nM), G (1000 nM), and TAM (2000 nM), as well as combinations of these treatments (G + G, TAM + G, and G + TAM) for 24 and 48 h.

The relationship between the quality of oncology nursing care and the resiliency and hope of patients with cancer: a cross-sectional study.

Background: Patients with cancer require emotional support in addition to specialised medical treatments for their physical ailments. The quality of nursing care, resilience and hope can influence a person's cancer trajectory, and understanding these factors and their relationship can be influential in improving the process for these patients.

Aim: This study examined the relationship between the quality of oncology nursing care and resilience and hope in patients with cancer.

Corrigendum: Global epidemiology and socioeconomic correlates of hypopharyngeal cancer in 2020 and its projection to 2040: findings from GLOBOCAN 2020.

[This corrects the article DOI: 10.3389/fonc.2024.

Clinicopathological Features of Frontal Fibrosing Alopecia (FFA) in 26 females: A Retrospective Study.

Background & Objective: FFA usually has a gradual subtle course and might be overlooked by physicians or misdiagnosed with other types of hair loss including androgenetic alopecia, traction alopecia, and other types of patterned alopecia. In this study, we described clinicopathological features of patients with FFA referring for skin biopsy.

Methods: This is a retrospective cross-sectional study on 26 patients with a diagnosis of FFA based on clinicopathological features.

Measuring Equality in Primary Health Care Budget Allocation in Iran, Using the Gini Coefficient Method.

Background: In Iran, one of the most important and influential sources for financing the Primary Health Care (PHC )is the government budget. This study was conducted with the aim of evaluating the allocation of the PHC budget and evaluating the equality in the allocation of these resources.

Methods: In this applied descriptive-analytical study, the study population included all of Iran's 31 provinces.

Differences in the Clinical Severity Scores of Hospitalized COVID-19 Patients across Different Phases of an Epidemic Wave in Iran: a Secondary Analysis.

Background: To reduce the clinical burden of COVID-19, healthcare providers, and policymakers need a clear understanding of the illness severity during epidemic waves. This study aimed to identify the clinical severity of patients with COVID-19 during different stages of an epidemic wave (pre-peak, peak, post-peak) in four provinces in Iran.

Methods: We conducted a secondary analysis of the data on COVID-19 patients admitted to hospitals (25,382 cases), which were recorded in the Medical Care Monitoring Center.

Disseminated Abdominal Cystic Echinococcosis After Blunt Abdominal Trauma: A Case Report.

Rupture of a hydatid cyst can lead to the development of a disseminated form of intra-abdominal cystic echinococcosis if not diagnosed and treated promptly. Anaphylactic shock is a definite indication of cyst rupture. The presented clinical case was a young athlete with a disseminated form of cystic echinococcosis, which was investigated in 2023 at the Syzganov National Scientific Center for Surgery of Kazakhstan.

The application of aptamer in tuberculosis diagnosis: a systematic review.

Tuberculosis represents a significant menace to health, leading to millions of cases and fatalities each year. Traditional diagnostic methods, while effective, have limitations, necessitating improved tools. Aptamers possessing remarkable specificity single-stranded DNA or RNA molecules promising in TB diagnosis due to their adaptability and precise biomarker detection capabilities.

Natural killer cells: a new promising source for developing chimeric antigen receptor anti-cancer cells in hematological malignancies.

In recent times, the application of CAR-T cell treatment has significantly progressed, showing auspicious treatment outcomes in hematologic malignancies. However, along with these advances, certain limitations and challenges hurdle the widespread utilization of this technology. Recently, CAR-NK cells have gained attention in cancer treatment, as this approach has an important advantage over CART therapy (i.

Effect of and chamomile aromas on anxiety and vital signs in cardiac care unit patients: A randomized clinical trial.

Background And Aim: Complementary therapies, such as aromatherapy, were used to manage acute and chronic symptoms of diseases. Anxiety symptoms and deviations in vital signs are frequently manifest in patients admitted to the cardiac care unit (CCU). This study aimed to evaluate the impact of and chamomile aromas on anxiety levels and vital signs of patients hospitalized in CCU.

Molecular and Microbial Detections of Streptococcus mutans and Lactobacilli in Dental Caries: An Experimental Study on Iranian Children Aged 5-9.

Objectives: Lactobacilli and Streptococcus mutans are stigmatized as cariogenic bacteria, but few studies have simultaneously examined the quantitative and qualitative aspects of lactobacilli and S. mutans in childhood dental caries. Therefore, this study aimed to detect the presence of S.