The Association of Cell-Free LncH19 and miR-29b Expression with the PI3K/AKT/HIF-1/VEGF Pathway in Patients with Diabetic Nephropathy: In Silico Prediction and Clinical Validation.

Diabetic nephropathy (DN) affects about one-third of patients with diabetes and can lead to end-stage renal disease despite numerous trials aimed at improving diabetic management. Non-coding RNAs (ncRNAs) represent a new frontier in DN research, as increasing evidence suggests their involvement in the occurrence and progression of DN. A growing body of evidence suggests that long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) in DN signaling pathways might serve as novel biomarkers or therapeutic targets, although this remains to be fully explored.

Silica Nanoparticles: A Promising Vehicle for Anti-Cancer Drugs Delivery.

The prevalence and death due to cancer have been rising over the past few decades, and eliminating tumour cells without sacrificing healthy cells remains a difficult task. Due to the low specificity and solubility of drug molecules, patients often require high dosages to achieve the desired therapeutic effects. Silica nanoparticles (SiNPs) can effectively deliver therapeutic agents to targeted sites in the body, addressing these challenges.

The Role of Telemedicine in Emergency Department Triage and Patient Care: A Systematic Review.

Overcrowding in emergency departments (EDs) is a global challenge, leading to prolonged waiting times and adverse patient outcomes. Telemedicine has emerged as a promising solution, enabling remote consultation, triage, and real-time specialist input. Despite its growing application, limited systematic research exists on its specific role in ED triage and care.

Adropin/Tirzepatide Combination Mitigates Cardiac Metabolic Aberrations in a Rat Model of Polycystic Ovarian Syndrome, Implicating the Role of the AKT/GSK3β/NF-κB/NLRP3 Pathway.

Polycystic ovarian syndrome (PCOS) is a multifaceted metabolic and hormonal disorder in females of reproductive age, frequently associated with cardiac disturbances. This research aimed to explore the protective potential of adropin and/or tirzepatide (Tirze) on cardiometabolic aberrations in the letrozole-induced PCOS model. Female Wistar non-pregnant rats were allotted into five groups: CON; PCOS; PCOS + adropin; PCOS + Tirze; and PCOS + adropin+ Tirze.

The Knowledge and Health Belief Model of Osteoporosis Prevention Among Females in Saudi Arabia.

Background Osteoporosis is the most common bone disease in humans, representing a major public health problem affecting women more commonly. The prevalence of osteoporosis in Saudi Arabia is high among females. Thus, the knowledge and Health Belief Model (HBM) of osteoporosis, which can be used to gain an understanding of health behaviors and reasons for non-compliance to osteoprotective recommendations, is necessary.

A Review of Current Techniques in Lip Reposition Surgery for Treating Excessive Gingival Display.

Excessive gingival display (EGD), commonly known as a gummy smile (GS), is a cosmetic concern that involves exposing a significant area of gum tissue during a smile, rendering it unaesthetic. Gingival exposure greater than 3 mm is deemed aesthetically displeasing and often necessitates treatment to mask the gummy smile. The causes of EGD are multifactorial, including altered passive eruption (APE), hypermobile upper lip (HUL), short lip length, increased vertical maxillary component, gingival hyperplasia, dentoalveolar extrusion, and more.

Current Updates on Nanotechnology-based Drug Delivery Platforms for Treating Alzheimer's with Herbal Drugs.

Alzheimer's disease (AD) is an irreversible brain disorder that led to memory loss and disrupts daily life. Earlier strategies to treat AD such as acetylcholinesterase inhibitor (AChEI) drugs are not showing effectiveness due to the inability to cross the blood-brain barrier. Moreover, traditional AChEI provides limited efficacy in terms of bioavailability and solubility for treating AD treatment.

Sun Exposure Awareness and Sunscreen Use Among College Students in Saudi Arabia: A Cross-Sectional Analysis.

Background: Excessive sun exposure is a significant risk factor for various skin conditions, including sunburn, premature aging, and skin cancer. This study aimed to assess the awareness, attitudes, and practices regarding sun exposure and sunscreen use among college students in Saudi Arabia.

Methodology: A cross-sectional study was conducted with 388 college students from various disciplines.

An integrated computational and graphical approach for evaluating the geochemistry and health risks of nitrate-contaminated water for six age groups.

Nitrate contamination in drinking water poses significant health risks, particularly in rapidly urbanizing areas of developing countries. This study presents an integrated computational and graphical approach to evaluate the geochemistry and health risks of nitrate-contaminated water for six age groups in Southeast, Nigeria. The research employed a detailed methodology combining water nutrient pollution index (WNPI), nitrate pollution index (NPI), water pollution index (WPI), geochemical plotting techniques, stoichiometry, and health risk computations.

Protective effects of Kaempferol on hepatic apoptosis via miR-26a-5p enhancement and regulation of TLR4/NF-κB and PKCδ in a rat model of nonalcoholic fatty liver.

This study aimed to evaluate kaempferol's, a dietary flavonoid widely present in plants, potential impact on nonalcoholic fatty liver disease (NAFLD) and its underlying mechanisms. In this study, 60 adult male rats were used and divided into a control group receiving a standard pellet diet, a kaempferol-treated group receiving kaempferol (250 mg/kg), a high-fat diet (HFD) group receiving HFD, and a kaempferol-treated HFD group. At the end of the experiment, the total lipid profile and liver enzymes were assayed in the serum.

Urinary Incontinence (UI) in Saudi Female Population: Prevalence, Risk Factors, and Impact on Quality of Life.

Background: Urinary incontinence (UI) is a prevalent health concern among women globally. However, its prevalence, associated risk factors, and impact on quality of life among Saudi women remain underexplored.

Objective: This study aimed to assess the prevalence of UI, identify its risk factors, and understand its impact on the quality of life among Saudi women.

A comprehensive evaluation of safety and awareness in eyebrow microblading: a cross-sectional study.

The importance of eyebrows in facial aesthetics has long been recognized, and eyebrows restoration is carried out by carefully depositing pigments into the epidermis. This cosmetic procedure is known as microblading, and it is very popular because of the progress made on social media platforms. This study was designed to determine the awareness of eyebrow microblading, complication and laser removal in general population of Saudi Arabia.

Harnessing the Power of Zinc Oxide Nanoparticles for Accelerated Wound Healing and Antimicrobial Action.

Introduction: Zinc oxide nanoparticles (ZnONPs) have been the subject of substantial research by virtue of their utility across extensive downstream applications. Moreover, the ZnONPs are inexpensive, reliable, and easy to produce. Green synthesis employing biological systems, particularly plant extracts, has arisen as a subject of study in nanotechnology and is gaining importance due to its multiple applications in biology, chemistry, physics, and medicine.

Advances in polysaccharide-based materials for biomedical and pharmaceutical applications: A comprehensive review.

Polysaccharides, the most abundant biopolymers in nature, have attracted the attention of researchers and clinicians due to its practicality in biomedical and pharmaceutical sciences. These biomaterials have high bioavailability and play structural and functional roles in living organisms. Polysaccharides are classified into several groups based on their origin, including plant polysaccharides and marine polysaccharides (like chitosan, hyaluronic acid, dextran, alginates, etc.

Assessment of Thyroid Function in Chronic Kidney Disease Patients at King Abdulaziz Medical City.

Background Chronic kidney disease (CKD) is a progressive and irreversible condition in which the kidneys lose their ability to perform synthetic, excretory, and metabolic functions. CKD is associated with various pathophysiological conditions that impact multiple organs, including the thyroid gland, which primarily secretes triiodothyronine (T3) and thyroxine (T4). This study aims to assess thyroid function in patients with CKD and explore the relationship between renal disease severity and thyroid function.

Recent advances in polysaccharide-based drug delivery systems for cancer therapy: a comprehensive review.

Cancer has a high rate of incidence and mortality throughout the world. Although several conventional approaches have been developed for the treatment of cancer, such as surgery, chemotherapy, radiotherapy and thermal therapy, they have remarkable disadvantages which result in inefficient treatment of cancer. For example, immunogenicity, prolonged treatment, non-specificity, metastasis and high cost of treatment, are considered as the major drawbacks of chemotherapy.

Comparative Evaluation of Mandibular Ridge Resorption in Post-menopausal Denture and Non-Denture-Wearing Females and Its Relation to Body Mass Index: An In-Vivo Study.

Background Mandibular ridge resorption is a common problem in edentulous individuals, particularly in post-menopausal women. Body mass index (BMI) has been suggested as a potential factor influencing ridge resorption, but the relationship between the two remains unclear. Methods A study was conducted to evaluate mandibular ridge resorption in post-menopausal denture-wearing females and its relation to body mass index.

Bile's Hidden Weapon: Modulating the Microbiome and Tumor Microenvironment.

The human gut microbiome is a dynamic and intricate ecosystem, composed of trillions of microorganisms that play a pivotal role in maintaining overall health and well-being. However, the gut microbiome is constantly exposed to various environmental factors, including the bile produced by the liver, which can significantly impact its composition and function. Bile acids, secreted by the liver and stored in the gallbladder, modulate the gut microbiome, influencing its composition and function.

Molecular Docking, Bioinformatic Analysis, and Experimental Verification for the Effect of Naringin on ADHD: Possible Inhibition of GSK-3β and HSP90.

One of the most abundant and growing neurodevelopmental disorders in recent decades is attention deficit hyperactivity disorder (ADHD). Many trials have been performed on using drugs for the improvement of ADHD signs. This study aimed to detect the possible interaction of naringin with Wnt/β-catenin signaling and its putative anti-inflammatory and protective effects in the mouse ADHD model based on bioinformatic, behavioral, and molecular investigations.

The Association Between Chronic Obstructive Pulmonary Disease (COPD) and Migraine: Systematic Review and Meta-Analysis.

: Migraine and chronic obstructive pulmonary disease (COPD) are both common chronic conditions that may share underlying pathophysiological mechanisms despite presenting with distinct clinical features. Understanding the association between these two conditions could enhance treatment strategies and improve patient outcomes. This review aims to evaluate the relationship between COPD and migraine, highlighting shared risk factors and identifying gaps in the existing literature.