255 results match your criteria: "hôpitaux Universitaires Paris Nord Val de Seine[Affiliation]"

Purpose: Hepatocellular carcinoma (HCC) is the third-leading cause of cancer-related deaths globally. Patients are often diagnosed with advanced disease, in which systemic and locoregional therapies are commonly used as first-line treatment. Such treatments can cause adverse events (AEs) that negatively affect quality of life (QoL), which is particularly undesirable where prognosis is poor.

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Urine collection can be challenging in studies involving small rodents like mice, as the actual methods of collection are anxiogenic and constrain animal welfare while having high variability in the volume of urine collected. To improve the current methods and eventually reduce the impact on the well-being of mice, we developed an innovative 3D-printed urine collection device (UCD). This two-compartment UCD is shaped to fit in classical husbandry cages and allows urine collection by spontaneous urination from two mice housed in their own cage without cross-contamination while enabling potential social interactions.

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Salvage Therapy Including Foscarnet and Ibalizumab for Multidrug-Resistant Human Immunodeficiency Virus Type 2 Infection.

Clin Infect Dis

April 2024

Assistance Publique-Hôpitaux de Paris.Nord, Service des Maladies Infectieuses et Tropicales, Hôpitaux Universitaires Paris Nord Val de Seine, site Bichat-Claude Bernard, Paris, France.

We evaluated Ibalizumab (IBA)-containing standardized optimized salvage regimen (with or without a 4-week foscarnet induction) in individuals harboring multidrug-resistant human immunodeficiency virus type 2 (HIV-2). Nine were included; 2 achieved virological suppression after foscarnet induction with a sustained suppression at Week 24 after IBA initiation, and an additional individual at Week 24 after Ibalizumab initiation.

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Arboviruses and pregnancy: are the threats visible or hidden?

Trop Dis Travel Med Vaccines

February 2024

Centre d'Investigation Clinique Antilles Guyane, Inserm CIC1424, Centre Hospitalier de Cayenne, 97300, Cayenne, French Guiana.

Article Synopsis
  • Mosquito-borne diseases like Zika are a big worry because they can seriously affect pregnant women and their babies, especially in poorer countries where not much research is done.
  • Even though millions of people get these diseases, there's not enough information about how they impact pregnant women, which can lead to serious health issues for mothers and babies.
  • It's really important to study these diseases more, create better tests and treatments, and develop vaccines to help protect pregnant women and improve healthcare for everyone around the world.
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Objective: To assess fetal and neonatal eyes abnormalities and their progression during the last ZIKV outbreak and summarize learned lessons.

Methods: A systematic review and meta-analysis was conducted by a team of obstetricians and ophthalmologists.

Results: Studies reporting ocular abnormalities during the prenatal ( = 5) and postnatal ( = 24) periods were included in the analysis.

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Background: Loa loa filariasis (loiasis) is still considered a relatively benign disease. However, recent epidemiologic data suggest increased mortality and morbidity in L. loa infected individuals.

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In spite of intensive research efforts driving spectacular advances in terms of prevention and treatments, cardiovascular diseases (CVDs) remain a leading health burden, accounting for 32% of all deaths (World Health Organization. "Cardiovascular Diseases (CVDs)." WHO, February 1, 2017, https://www.

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Causes and consequences of fever in Amazonian pregnant women: A large retrospective study from French Guiana.

PLoS Negl Trop Dis

October 2023

Centre d'Investigation Clinique Antilles-Guyane, Epidémiologie Clinique, CIC INSERM 1424, DRISP, Centre hospitalier de Cayenne, Cayenne, French Guiana.

Objective: The aim of this study was to describe different causes and consequences of fever during pregnancy in Western French Guiana and along the Maroni River.

Study Design: A retrospective single-center study including all patients with a history of documented fever ≥ 38°C during pregnancy at the West French Guiana Hospital for 9 years. Postpartum fever and nosocomial infections were excluded.

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Article Synopsis
  • Neutrophils are special cells that help fight infections by moving to areas in the body where there is inflammation.
  • This study looked at a molecule called CD31, which helps neutrophils detach and move away from blood vessels to reach the inflamed areas.
  • The researchers discovered that CD31 helps neutrophils change shape and detach properly, showing it plays an important role in how these cells migrate where they are needed the most.
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Background: Case reports have hypothesised that proteinuria, sometimes with glomerulopathy or nephrotic syndromes, might be associated with loiasis. To our knowledge, no study has been done to assess this association. We aimed to investigate the association between Loa loa microfilariae burden and proteinuria.

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Impact of COVID-19 on the management of hepatocellular carcinoma in a high-prevalence area: What's new 12 months later?

Ann Hepatol

May 2024

INSERM U955, Team "Pathophysiology and Therapy of Chronic Viral Hepatitis and Related Cancers", Créteil, France - Assistance Publique-Hôpitaux de Paris, France; Department of Hepatology, AP-HP, Hôpital Henri-Mondor, F-94010 Créteil, France; Paris Est Créteil University, UPEC, Créteil, France. Electronic address:

Introduction And Objectives: The lockdown policy introduced in 2020 to minimize the spread of the COVID-19 pandemic, significantly affected the management and care of patients affected by hepatocellular carcinoma (HCC). The aim of this follow-up study was to determine the 12 months impact of the COVID-19 pandemic on the cohort of patients affected by HCC during the lockdown, within six French academic referral centers in the metropolitan area of Paris.

Materials And Methods: We performed a 12 months follow-up of the cross-sectional study cohort included in 2020 on the management of patients affected by HCC during the first six weeks of the COVID-19 pandemic (exposed), compared to the same period in 2019 (unexposed).

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Significance Statement: Kidney-derived thrombopoietin (TPO) increases myeloid cell and platelet production during antibody-mediated chronic kidney disease (AMCKD) in a mouse model, exacerbating chronic thromobinflammation in microvessels. The effect is mirrored in patients with extracapillary glomerulonephritis associated with thromboinflammation, TGF β -dependent glomerulosclerosis, and increased bioavailability of TPO. Neutralization of TPO in mice normalized hematopoiesis, reduced chronic thromboinflammation, and ameliorated renal disease.

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Development of a clot-adhesive coating to improve the performance of thrombectomy devices.

J Neurointerv Surg

December 2023

Department of Radiology, New England Center for Stroke Research, UMass Chan Medical School, Worcester, Massachusetts, USA.

Background: The first-pass complete recanalization by mechanical thrombectomy (MT) for the treatment of stroke remains limited due to the poor integration of the clot within current devices. Aspiration can help retrieval of the main clot but fails to prevent secondary embolism in the distal arterial territory. The dense meshes of extracellular DNA, recently described in stroke-related clots, might serve as an anchoring platform for MT devices.

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Article Synopsis
  • Tislelizumab, an antibody targeting the PD-1 protein, showed some effectiveness and safety for treating advanced hepatocellular carcinoma (HCC) in patients who had received prior therapies.
  • In a phase 2 study involving 249 patients, the objective response rate (ORR) was 13%, with a disease control rate of 53% and a median overall survival of 13.2 months.
  • Side effects were mostly manageable, with only 15% of patients experiencing severe treatment-related adverse events, and no treatment-related deaths reported.
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Introduction: Gaucher disease is an autosomal recessive genetic disorder. It is caused by a deficiency of the lysosomal enzyme, glucocerebrosidase which leads to an accumulation of glucosylceramide in the macrophages. Splenomegaly, hepatomegaly, cytopenias (anemia, thrombocytopenia) and bone disorders are the main symptoms.

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[Fertility preservation in transgender people].

Med Sci (Paris)

November 2022

CECOS, hôpitaux universitaires Paris Seine-Saint-Denis, hôpital Jean Verdier, Bondy, France - Inserm U1016, équipe « Génomique, épigénétique et physiologie de la reproduction », Institut Cochin, université Paris Cité, Paris, France - Service de biologie de la reproduction, hôpitaux Universitaires Paris Nord Val de Seine, AP-HP, hôpital Bichat, Paris, France.

Most of transgender people plan to have a family but their fertility may be affected by gender affirmation. Hormone therapy can permanently affect gamete production, especially in trans women. Sex reassignment surgery leads to permanent sterility.

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While considerable efforts have been accomplished to standardize the measurement of plasma creatinine (PCr), urine creatinine (UCr) has not been subject to the same scrutiny. UCr is importantly used when measuring biomarkers in spot urines, to assess urine output and variable dilution of urine samples. Here, we report underestimation of Jaffe UCr measurements on the Siemens Dimension Vista® analyzer, critically affecting samples with UCr ≤2 mmol/L.

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Objective: To investigate whether oral antimicrobial prophylaxis as an adjunct to intravenous antibiotic prophylaxis reduces surgical site infections after elective colorectal surgery.

Design: Multicentre, randomised, double blind, placebo controlled trial.

Setting: 11 university and non-university hospitals in France between 25 May 2016 and 8 August 2019.

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Over the past four decades, studies of various designs have reported spatial and temporal trends in human semen quality. Several standardized-methodology studies in homogeneous populations that compare specific cities within a country or a continent provide clear evidence of geographical differences in sperm production, even over short distances within the same country. Human sperm production is widely believed to be declining over time, but evidence from the scientific literature is less clear.

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The conundrum of the definition of haemorrhagic shock: a pragmatic exploration based on a scoping review, experts' survey and a cohort analysis.

Eur J Trauma Emerg Surg

December 2022

Department of Anesthesiology and Critical Care, Hôpital Européen Georges Pompidou, APHP, Université de Paris, 20 rue Leblanc 15, Paris, France.

Purpose: Traumatic hemorrhagic shock (THS) is a complex, dynamic process and, no consensual definition of THS is available. This study aims (1) to explore existing definitions of traumatic hemorrhagic shock (THS), (2) to identify essential components of these definitions and (3) to illustrate in a pragmatic way the consequences of applying five of these definitions to a trauma registry.

Methods: We conducted (1) a scoping review to identify the definitions used for traumatic hemorrhagic shock (THS); (2) an international experts survey to rank by relevance a selection of components extracted from these definitions and (3) a registry-based analysis where several candidate definitions were tested in a large trauma registry to evaluate how the use of different definitions affected baseline characteristics, resources use and patient outcome.

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Article Synopsis
  • This study evaluates the quality of life (QOL) for patients with hepatocellular carcinoma (HCC) undergoing different treatments: transarterial radioembolization (TARE), the combination of atezolizumab and bevacizumab, and sorafenib.
  • The methods involved analyzing patient data from the SARAH and IMbrave150 trials, adjusting for various health factors to ensure fair comparisons of QOL deterioration over time.
  • Results showed that patients receiving TARE had a longer median time to deterioration in QOL compared to those on atezolizumab-bevacizumab, while those on sorafenib had the shortest median TTD in QOL.
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Measurement of glycosylated ferritin with Concanavalin A: Assay design, optimization and validation.

J Chromatogr B Analyt Technol Biomed Life Sci

April 2022

Département de Biochimie, Hôpitaux Universitaires Paris Nord Val de Seine - site Bichat, Assistance Publique Hôpitaux de Paris, Paris, France.

Introduction: Ferritin is the major iron-storage glycoprotein found in all tissues. Ferritin glycosylation can be assessed by the differential affinities of ferritin glycoforms for Concanavalin A (ConA), a lectin. The fraction of serum ferritin bound to ConA is called "glycosylated ferritin" (GF).

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Chagas disease is a debilitating and often fatal pathology resulting from infection by the protozoan parasite . In its recommendations, the World Health Organization states that the diagnosis of infection is usually based on the detection of antibodies against antigens and performed with two methodologically different assays. An inconclusive result can be resolved with a third "confirmatory" assay.

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This expert consensus document represents an initiative by the European Neuroendocrine Tumor Society (ENETS) to provide guidance for synoptic reporting of radiological examinations critical to the diagnosis, grading, staging and treatment of neuroendocrine neoplasms (NENs). Template drafts for initial tumor staging and follow-up by computed tomography (CT) and magnetic resonance imaging (MRI) were established, based on existing institutional and organisational reporting templates relevant for NEN imaging, and applying the RadLex lexicon of radiological information (Radiological Society of North America), for consistency regarding the radiological terms. During the ENETS Scientific Advisory Board meeting 2018, the template drafts were subject to iterative interdisciplinary discussions among experts in imaging, surgery, gastroenterology, oncology and pathology.

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Health-related quality of life in locally advanced hepatocellular carcinoma treated by either radioembolisation or sorafenib (SARAH trial).

Eur J Cancer

September 2021

Université de Paris, Centre de Recherche de l'Inflammation (CRI), INSERM U1149, F-75018 Paris, France; Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris Nord Val de Seine, Hôpital Beaujon, Clichy, France.

Background: The aim of this ancillary study of the SARAH trial is to compare health-related quality of life (HRQoL) in patients with locally advanced or inoperable hepatocellular carcinoma (HCC) treated with transarterial radioembolisation (TARE) or sorafenib.

Methods: This study included randomised patients who received either TARE or at least one dose of sorafenib with no major deviation in the protocol and who had at least one QoL follow-up assessment in addition to the baseline evaluation. QoL was assessed from the date of randomisation using the European Organisation for Research and Treatment of Cancer QLQ-C30 questionnaire, until disease progression or other reasons for stopping study participation.

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