255 results match your criteria: "hôpitaux Universitaires Paris Nord Val de Seine[Affiliation]"
Purpose: Hepatocellular carcinoma (HCC) is the third-leading cause of cancer-related deaths globally. Patients are often diagnosed with advanced disease, in which systemic and locoregional therapies are commonly used as first-line treatment. Such treatments can cause adverse events (AEs) that negatively affect quality of life (QoL), which is particularly undesirable where prognosis is poor.
View Article and Find Full Text PDFLab Anim
December 2024
Université Paris Cité and Université Sorbonne Paris Nord, INSERM, LVTS, Paris, France.
Urine collection can be challenging in studies involving small rodents like mice, as the actual methods of collection are anxiogenic and constrain animal welfare while having high variability in the volume of urine collected. To improve the current methods and eventually reduce the impact on the well-being of mice, we developed an innovative 3D-printed urine collection device (UCD). This two-compartment UCD is shaped to fit in classical husbandry cages and allows urine collection by spontaneous urination from two mice housed in their own cage without cross-contamination while enabling potential social interactions.
View Article and Find Full Text PDFClin Infect Dis
April 2024
Assistance Publique-Hôpitaux de Paris.Nord, Service des Maladies Infectieuses et Tropicales, Hôpitaux Universitaires Paris Nord Val de Seine, site Bichat-Claude Bernard, Paris, France.
We evaluated Ibalizumab (IBA)-containing standardized optimized salvage regimen (with or without a 4-week foscarnet induction) in individuals harboring multidrug-resistant human immunodeficiency virus type 2 (HIV-2). Nine were included; 2 achieved virological suppression after foscarnet induction with a sustained suppression at Week 24 after IBA initiation, and an additional individual at Week 24 after Ibalizumab initiation.
View Article and Find Full Text PDFTrop Dis Travel Med Vaccines
February 2024
Centre d'Investigation Clinique Antilles Guyane, Inserm CIC1424, Centre Hospitalier de Cayenne, 97300, Cayenne, French Guiana.
Ocul Immunol Inflamm
November 2024
Department of Obstetrics and Gynaecology, West French Guiana Hospital Center, Saint-Laurent-du-Maroni, French Guiana.
Objective: To assess fetal and neonatal eyes abnormalities and their progression during the last ZIKV outbreak and summarize learned lessons.
Methods: A systematic review and meta-analysis was conducted by a team of obstetricians and ophthalmologists.
Results: Studies reporting ocular abnormalities during the prenatal ( = 5) and postnatal ( = 24) periods were included in the analysis.
PLoS Negl Trop Dis
January 2024
TransVIHMI, Université de Montpellier, INSERM Unité 1175, Institut de Recherche pour le Développement (IRD), Montpellier, France.
Background: Loa loa filariasis (loiasis) is still considered a relatively benign disease. However, recent epidemiologic data suggest increased mortality and morbidity in L. loa infected individuals.
View Article and Find Full Text PDFPeriodontol 2000
November 2023
UFR d'Odontologie, Université Paris Cité, Paris, France.
In spite of intensive research efforts driving spectacular advances in terms of prevention and treatments, cardiovascular diseases (CVDs) remain a leading health burden, accounting for 32% of all deaths (World Health Organization. "Cardiovascular Diseases (CVDs)." WHO, February 1, 2017, https://www.
View Article and Find Full Text PDFPLoS Negl Trop Dis
October 2023
Centre d'Investigation Clinique Antilles-Guyane, Epidémiologie Clinique, CIC INSERM 1424, DRISP, Centre hospitalier de Cayenne, Cayenne, French Guiana.
Objective: The aim of this study was to describe different causes and consequences of fever during pregnancy in Western French Guiana and along the Maroni River.
Study Design: A retrospective single-center study including all patients with a history of documented fever ≥ 38°C during pregnancy at the West French Guiana Hospital for 9 years. Postpartum fever and nosocomial infections were excluded.
Elife
August 2023
Université Paris Cité and Université Sorbonne Paris Nord, INSERM, Laboratory for Vascular Translational Science (LVTS), Paris, France.
Lancet Microbe
September 2023
TransVIHMI, Université de Montpellier, INSERM Unité 1175, Institut de Recherche pour le Développement, Montpellier, France.
Background: Case reports have hypothesised that proteinuria, sometimes with glomerulopathy or nephrotic syndromes, might be associated with loiasis. To our knowledge, no study has been done to assess this association. We aimed to investigate the association between Loa loa microfilariae burden and proteinuria.
View Article and Find Full Text PDFAnn Hepatol
May 2024
INSERM U955, Team "Pathophysiology and Therapy of Chronic Viral Hepatitis and Related Cancers", Créteil, France - Assistance Publique-Hôpitaux de Paris, France; Department of Hepatology, AP-HP, Hôpital Henri-Mondor, F-94010 Créteil, France; Paris Est Créteil University, UPEC, Créteil, France. Electronic address:
Introduction And Objectives: The lockdown policy introduced in 2020 to minimize the spread of the COVID-19 pandemic, significantly affected the management and care of patients affected by hepatocellular carcinoma (HCC). The aim of this follow-up study was to determine the 12 months impact of the COVID-19 pandemic on the cohort of patients affected by HCC during the lockdown, within six French academic referral centers in the metropolitan area of Paris.
Materials And Methods: We performed a 12 months follow-up of the cross-sectional study cohort included in 2020 on the management of patients affected by HCC during the first six weeks of the COVID-19 pandemic (exposed), compared to the same period in 2019 (unexposed).
J Am Soc Nephrol
July 2023
Université Paris Cité and Université Sorbonne Paris Nord, INSERM U1148, Laboratory for vascular science (LVTS), Paris, France.
Significance Statement: Kidney-derived thrombopoietin (TPO) increases myeloid cell and platelet production during antibody-mediated chronic kidney disease (AMCKD) in a mouse model, exacerbating chronic thromobinflammation in microvessels. The effect is mirrored in patients with extracapillary glomerulonephritis associated with thromboinflammation, TGF β -dependent glomerulosclerosis, and increased bioavailability of TPO. Neutralization of TPO in mice normalized hematopoiesis, reduced chronic thromboinflammation, and ameliorated renal disease.
View Article and Find Full Text PDFJ Neurointerv Surg
December 2023
Department of Radiology, New England Center for Stroke Research, UMass Chan Medical School, Worcester, Massachusetts, USA.
Background: The first-pass complete recanalization by mechanical thrombectomy (MT) for the treatment of stroke remains limited due to the poor integration of the clot within current devices. Aspiration can help retrieval of the main clot but fails to prevent secondary embolism in the distal arterial territory. The dense meshes of extracellular DNA, recently described in stroke-related clots, might serve as an anchoring platform for MT devices.
View Article and Find Full Text PDFLiver Cancer
February 2023
Department of Oncology, National Taiwan University Cancer Center and National Taiwan University Hospital, Taipei, Taiwan.
Rev Med Interne
February 2023
Service de médecine interne et polyvalente, centre hospitalier Simone Veil, 1 mail Pierre-Charlot, Blois, France.
Introduction: Gaucher disease is an autosomal recessive genetic disorder. It is caused by a deficiency of the lysosomal enzyme, glucocerebrosidase which leads to an accumulation of glucosylceramide in the macrophages. Splenomegaly, hepatomegaly, cytopenias (anemia, thrombocytopenia) and bone disorders are the main symptoms.
View Article and Find Full Text PDFMed Sci (Paris)
November 2022
CECOS, hôpitaux universitaires Paris Seine-Saint-Denis, hôpital Jean Verdier, Bondy, France - Inserm U1016, équipe « Génomique, épigénétique et physiologie de la reproduction », Institut Cochin, université Paris Cité, Paris, France - Service de biologie de la reproduction, hôpitaux Universitaires Paris Nord Val de Seine, AP-HP, hôpital Bichat, Paris, France.
Most of transgender people plan to have a family but their fertility may be affected by gender affirmation. Hormone therapy can permanently affect gamete production, especially in trans women. Sex reassignment surgery leads to permanent sterility.
View Article and Find Full Text PDFClin Biochem
January 2023
Département de Biochimie, Hôpitaux Universitaires Paris Nord Val de Seine - site Bichat, Assistance Publique Hôpitaux de Paris, Paris, France. Electronic address:
While considerable efforts have been accomplished to standardize the measurement of plasma creatinine (PCr), urine creatinine (UCr) has not been subject to the same scrutiny. UCr is importantly used when measuring biomarkers in spot urines, to assess urine output and variable dilution of urine samples. Here, we report underestimation of Jaffe UCr measurements on the Siemens Dimension Vista® analyzer, critically affecting samples with UCr ≤2 mmol/L.
View Article and Find Full Text PDFBMJ
November 2022
Département Anesthésie Réanimation, Assistance publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris Nord Val de Seine, Hôpital Beaujon, Clichy, France.
Objective: To investigate whether oral antimicrobial prophylaxis as an adjunct to intravenous antibiotic prophylaxis reduces surgical site infections after elective colorectal surgery.
Design: Multicentre, randomised, double blind, placebo controlled trial.
Setting: 11 university and non-university hospitals in France between 25 May 2016 and 8 August 2019.
Nat Rev Urol
October 2022
Université Rennes, INSERM, EHESP, IRSET-UMR_S 1085, Rennes, France.
Over the past four decades, studies of various designs have reported spatial and temporal trends in human semen quality. Several standardized-methodology studies in homogeneous populations that compare specific cities within a country or a continent provide clear evidence of geographical differences in sperm production, even over short distances within the same country. Human sperm production is widely believed to be declining over time, but evidence from the scientific literature is less clear.
View Article and Find Full Text PDFEur J Trauma Emerg Surg
December 2022
Department of Anesthesiology and Critical Care, Hôpital Européen Georges Pompidou, APHP, Université de Paris, 20 rue Leblanc 15, Paris, France.
Purpose: Traumatic hemorrhagic shock (THS) is a complex, dynamic process and, no consensual definition of THS is available. This study aims (1) to explore existing definitions of traumatic hemorrhagic shock (THS), (2) to identify essential components of these definitions and (3) to illustrate in a pragmatic way the consequences of applying five of these definitions to a trauma registry.
Methods: We conducted (1) a scoping review to identify the definitions used for traumatic hemorrhagic shock (THS); (2) an international experts survey to rank by relevance a selection of components extracted from these definitions and (3) a registry-based analysis where several candidate definitions were tested in a large trauma registry to evaluate how the use of different definitions affected baseline characteristics, resources use and patient outcome.
Adv Ther
May 2022
Centre de Recherche de l'Inflammation, INSERM U1149, Université de Paris Sorbonne Cité, 75018, Paris, France.
J Chromatogr B Analyt Technol Biomed Life Sci
April 2022
Département de Biochimie, Hôpitaux Universitaires Paris Nord Val de Seine - site Bichat, Assistance Publique Hôpitaux de Paris, Paris, France.
Introduction: Ferritin is the major iron-storage glycoprotein found in all tissues. Ferritin glycosylation can be assessed by the differential affinities of ferritin glycoforms for Concanavalin A (ConA), a lectin. The fraction of serum ferritin bound to ConA is called "glycosylated ferritin" (GF).
View Article and Find Full Text PDFPathogens
November 2021
Service de Parasitologie-Mycologie, APHP Sorbonne Université Hôpital Pitié-Salpêtrière, 75013 Paris, France.
Chagas disease is a debilitating and often fatal pathology resulting from infection by the protozoan parasite . In its recommendations, the World Health Organization states that the diagnosis of infection is usually based on the detection of antibodies against antigens and performed with two methodologically different assays. An inconclusive result can be resolved with a third "confirmatory" assay.
View Article and Find Full Text PDFJ Neuroendocrinol
March 2022
Department of Surgical Sciences, Radiology & Molecular Imaging, Uppsala University Hospital, Uppsala University, Uppsala, Sweden.
This expert consensus document represents an initiative by the European Neuroendocrine Tumor Society (ENETS) to provide guidance for synoptic reporting of radiological examinations critical to the diagnosis, grading, staging and treatment of neuroendocrine neoplasms (NENs). Template drafts for initial tumor staging and follow-up by computed tomography (CT) and magnetic resonance imaging (MRI) were established, based on existing institutional and organisational reporting templates relevant for NEN imaging, and applying the RadLex lexicon of radiological information (Radiological Society of North America), for consistency regarding the radiological terms. During the ENETS Scientific Advisory Board meeting 2018, the template drafts were subject to iterative interdisciplinary discussions among experts in imaging, surgery, gastroenterology, oncology and pathology.
View Article and Find Full Text PDFEur J Cancer
September 2021
Université de Paris, Centre de Recherche de l'Inflammation (CRI), INSERM U1149, F-75018 Paris, France; Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris Nord Val de Seine, Hôpital Beaujon, Clichy, France.
Background: The aim of this ancillary study of the SARAH trial is to compare health-related quality of life (HRQoL) in patients with locally advanced or inoperable hepatocellular carcinoma (HCC) treated with transarterial radioembolisation (TARE) or sorafenib.
Methods: This study included randomised patients who received either TARE or at least one dose of sorafenib with no major deviation in the protocol and who had at least one QoL follow-up assessment in addition to the baseline evaluation. QoL was assessed from the date of randomisation using the European Organisation for Research and Treatment of Cancer QLQ-C30 questionnaire, until disease progression or other reasons for stopping study participation.