372 results match your criteria: "groupement hospitalier nord[Affiliation]"
Int J Neonatal Screen
November 2024
Laboratoire de Biologie Médicale Multi-Sites (LBMMS), Service de Biochimie et Biologie Moléculaire Grand Est, Hospices Civils de Lyon, 69500 Bron, France.
In France, sickle cell disease newborn screening (SCD NBS) has been targeted to at-risk regions since 1984, but generalization to the whole population will be implemented from November 2024. Although tandem mass spectrometry (MS/MS) is already used for the NBS of several inherited metabolic diseases, its application for SCD NBS has not been widely adopted worldwide. The aim of this study was to evaluate a dedicated MS/MS kit (Targeted MS/MS Hemo, ZenTech, LaCAR Company, Liege, Belgium) for SCD NBS and to compare the results obtained with those from an NBS reference center using matrix-assisted laser desorption/ionization time of flight (MALDI-TOF) and cation-exchange high-performance liquid chromatography (CE-HPLC, Variant NBS, Biorad Laboratories, Inc.
View Article and Find Full Text PDFHead Neck
December 2024
Oral and Maxillofacial Surgery Department, Groupement Hospitalier Nord, Hospices Civils de Lyon, Lyon, France.
J Antimicrob Chemother
December 2024
Facultés de Médecine et de Pharmacie de Lyon, Univ Lyon, Université Claude Bernard Lyon 1, Lyon, France.
Background And Objectives: Cefiderocol approved dosages are based on a prolonged infusion (PI) of 3 h that may not be adequate in all settings The objective of this study was to identify alternative cefiderocol dosage regimens based on short infusion (SI) or continuous infusion (CI).
Methods: We performed 1000-patient pharmacokinetic/pharmacodynamic (PK/PD) simulations based on a reference population model. Drug penetration into the epithelial lining fluid (ELF) was considered for pneumonia.
Ann Clin Microbiol Antimicrob
December 2024
Laboratoire de Biologie médicale de Référence des Nocardioses, Groupement Hospitalier Nord, Institut des Agents Infectieux, Hospices civils de Lyon, Lyon, France.
Background: Drug susceptibility testing (DST) for Nocardia spp. is essential to initiate effective antibiotic therapy. Currently, the only recommended technique is the determination of minimum inhibitory concentrations (MICs) by microdilution.
View Article and Find Full Text PDFAnn Pharm Fr
December 2024
Académie nationale de pharmacie, Paris, France; Service de pharmacie, groupement hospitalier Nord, hospices civils de Lyon, Lyon, France; Malaria Research Unit, SMITh, ICBMS UMR 5246, université de Lyon, Lyon, France.
Antifungal resistance in humans is a clinical reality of increasing incidence that raises problems for patient care. In this current event, we discuss the link that can be made between the presence of antifungals in the environment and the development of resistance in humans, as well as the ecotoxicology of antifungals. The presence of antifungals in the environment has a health, but also an ecological impact.
View Article and Find Full Text PDFJ Hosp Infect
November 2024
HydroSciences Montpellier, IRD, CNRS, Montpellier University, Hospital Hygiene and Infection Control Department, University Hospital of Montpellier, Montpellier, France.
Ann Pharm Fr
October 2024
Service pharmaceutique, hôpital de la Croix-Rousse, groupement hospitalier nord, hospices civils de Lyon, 103, grande rue de la Croix-Rousse, 69317 Lyon cedex, France. Electronic address:
Ann Pharm Fr
October 2024
Service pharmacie, groupement hospitalier Nord, hospices civils de Lyon, Lyon, France; ISPB, faculté de pharmacie de Lyon, université de Lyon, université de Lyon 1, Lyon, France; UMR CNRS 5558, laboratoire de biométrie et biologie évolutive, université de Lyon, université de Lyon 1, Villeurbanne, France.
Given its good tolerance and broad-spectrum, isavuconazole is increasingly used off-label as an empirical therapy of invasive fungal infections. We retrospectively reviewed isavuconazole empirical treatment during a 12-month period in four hospitals. During isavuconazole treatment (n=27), none of the patients had a mycological evidence for fungal infection, but 19% (5/27) developed liver test abnormalities without leading to isavuconazole discontinuation.
View Article and Find Full Text PDFBMJ Open
October 2024
Médecine Intensive Réanimation, Centre Hospitalier Universitaire de Poitiers, Poitiers, France.
Introduction: First-line oxygenation strategy in patients with acute hypoxaemic respiratory failure consists in standard oxygen or high-flow nasal oxygen therapy. Clinical practice guidelines suggest the use of high-flow nasal oxygen rather than standard oxygen. However, findings remain contradictory with a low level of certainty.
View Article and Find Full Text PDFAliment Pharmacol Ther
January 2025
French Faecal Transplant Group (GFTF), France.
Anaesth Crit Care Pain Med
October 2024
Université de Poitiers, INSERM, PHAR2, CHU de Poitiers Service d'Anesthésie Réanimation Médecine Péri-opératoire, F-86000 Poitiers 86021, France. Electronic address:
Clin Pharmacokinet
August 2024
Service de Pharmacologie, Toxicologie et Pharmacovigilance, CHU Limoges, France.
Background And Objective: The dosage of daptomycin is usually based on body weight. However, it has been shown that this approach yields too high an exposure in obese patients. Pharmacokinetic and pharmacodynamic indexes (PK/PD) have been proposed for daptomycin's antibacterial effect (AUC/CMI >666) and toxicity (C0 > 24.
View Article and Find Full Text PDFAnn Pharm Fr
November 2024
Association Bon Usage du Médicament, Lyon, France.
Through their footprint throughout their life cycle, from production to use, medicines have a significant impact on the environment. Reducing this impact is rarely considered from the perspective of the choices that healthcare professionals might have to make when prescribing or dispensing medicines. Should we consider environmental impact, alongside effectiveness and tolerance, one of the dimensions of the proper use of medicines? To address this question, the 5th Forum of the Association for the Proper Use of Medicines highlighted the main sources of pharmaceutical pollution: the carbon footprint linked to production, greenhouse gas emissions, the impact of residues on water and waste from packaging.
View Article and Find Full Text PDFJ Allergy Clin Immunol
November 2024
Hospices Civils de Lyon, Lyon, France; Centre de Références Maladies Rares, Rhumatismes inflammatoires et les maladies Auto-Immunes Systémiques rares de l'Enfant (RAISE), Lyon, France; Centre International de Recherche en Infectiologie (CIRI), Institut National de la Santé et de la Recherche Médicale (INSERM) U1111, Centre National de la Recherche Scientifique Unité Mixte de Recherche (UMR) 5308, École Normale Supérieure de Lyon, Université Claude Bernard Lyon, Lyon, France; Department of Pediatrics Nephrology, Rheumatology, and Dermatology, Hôpital Femme-Mère-Enfant, Bron, France. Electronic address:
J Allergy Clin Immunol Pract
October 2024
University Clinic of Respiratory and Allergic Diseases, Pulmonary & Allergy Department, Golnik, Slovenia; Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Int J Infect Dis
September 2024
Univ. Bordeaux, INSERM, MART, Bordeaux, France; INRIA SISTM Team, Talence, France; CHU de Bordeaux, Service d'information médicale, INSERM, Bordeaux, France.
Background: This study aimed to compare the humoral responses to mRNA COVID-19 vaccination in people living with HIV (PWH) and HIV-negative individuals.
Methods: We included PWH with an undetectable viral load under ART and HIV-negative participants from the French nationwide ANRS COV-POPART cohort who had received two doses of vaccine as a primary vaccination. We compared humoral response between controls and PWH, stratified by CD4 cell count (<200/mm and ≥200/mm CD4 cell counts) at 1, 6, and 12 months after primary vaccination.
J Allergy Clin Immunol
August 2024
Centre International de Recherche en Infectiologie (CIRI), INSERM U1111, Unité Mixte de Recherche 5308, Centre national de la recherche scientifique, Ecole Normale Supérieure de Lyon, Lyon, France. Electronic address:
Background: The contribution of Staphylococcus aureus to the exacerbation of atopic dermatitis (AD) is widely documented, but its role as a primary trigger of AD skin symptoms remains poorly explored.
Objectives: This study sought to reappraise the main bacterial factors and underlying immune mechanisms by which S aureus triggers AD-like inflammation.
Methods: This study capitalized on a preclinical model, in which different clinical isolates were applied in the absence of any prior experimental skin injury.
J Antimicrob Chemother
June 2024
Service Pharmacie, Groupement Hospitalier Nord, Hospices Civils de Lyon, Lyon, France.
Background: Invasive candidiasis is still recognized as a major cause of morbidity and mortality. To support clinicians in the optimal use of antifungals for the treatment of invasive candidiasis, a computerized decision support system (CDSS) was developed based on institutional guidelines.
Objectives: To evaluate the correlation of this newly developed CDSS with clinical practices, we set-up a retrospective multicentre cohort study with the aim of providing the concordance rate between the CDSS recommendation and the medical prescription (NCT05656157).
Eur J Clin Microbiol Infect Dis
June 2024
Laboratoire des Mycobactérie, Laboratoire de biologie médicale multi-site, Groupement Hospitalier Nord, Hospices civils de Lyon, Lyon, France.
Purpose: Rapid, reliable identification of mycobacteria from positive cultures is essential for patient management, particularly for the differential diagnosis of Mycobacterium tuberculosis complex (MTBC) and nontuberculous mycobacteria (NTM) species. The aim of the present study was to evaluate a new "In-Vitro-Diagnostic"-certified PCR kit, FluoroType®-Mycobacteria VER 1.0 (Hain Lifescience GmbH) for NTM and MTBC identification from cultures.
View Article and Find Full Text PDFViruses
March 2024
Virpath Unit, CIRI, Inserm U1111, CNRS, UMR5308, ENS Lyon, Université Claude Bernard Lyon 1, F-69372 Lyon, France.
The H274Y substitution (N2 numbering) in neuraminidase (NA) N1 confers oseltamivir resistance to A(H1N1) influenza viruses. This resistance has been associated with reduced N1 expression using transfected cells, but the effect of this substitution on the enzymatic properties and on the expression of other group-1-NA subtypes is unknown. The aim of the present study was to evaluate the antiviral resistance, enzymatic properties, and expression of wild-type (WT) and H274Y-substituted NA for each group-1-NA.
View Article and Find Full Text PDFArch Dis Child
July 2024
Pediatric Intensive Care Unit, Robert-Debré Mother-Child University Hospital, Paris, France.
Background: Paediatric sepsis is the leading cause of death in children under 5 years. No studies have evaluated the application of the Surviving Sepsis Campaign 2020 (SSC-2020) guidelines in paediatric emergency departments (PEDs).
Objective: To assess physician adherence to the SSC-2020 fluid resuscitation guidelines in children with suspected septic shock in PEDs.
J Fungi (Basel)
January 2024
Malaria Research Unit, University Lyon, UMR 5246 CNRS-INSA-CPE-University Lyon1, 69100 Villeurbanne, France.
The World Health Organization (WHO) recently published a list of fungal priority pathogens, including and . The increased level of resistance of is raising concern, considering the availability of only four classes of medicine. The WHO is seeking novel agent classes with different targets and mechanisms of action.
View Article and Find Full Text PDFAnn Pharm Fr
May 2024
Service pharmaceutique, hôpital de la Croix-Rousse, groupement hospitalier Nord, hospices civils de Lyon, 103, Grande rue de la Croix-Rousse, 69317 Lyon cedex 04, France. Electronic address:
Objectives: In a context of heparin shortage, we studied the wasted quantities in three intensive care units (ICU) of a university hospital where two electric syringe pump (ESP) heparin protocols coexist (20,000UI/48mL used in the cardiology ICU and 25,000UI/50mL use in the medical and surgical ICUs).
Method: We performed a prospective observational study of patients treated with heparin ESP. We collected the information recorded in the prescription software connected to the ESP (dosage, start time, infusion rate, interruption times, date and time of end of treatment).
J Antimicrob Chemother
April 2024
ISPB-Faculté de Pharmacie de Lyon, Université Claude Bernard Lyon 1, Lyon, France.
Clin Infect Dis
October 2024
Groupement Hospitalier Nord, Service de Pharmacie, Hospices Civils de Lyon, Lyon, France.