11 results match your criteria: "groupe hospitalier Cochin-St-Vincent de Paul[Affiliation]"
Lancet Respir Med
October 2023
Department of Critical Care Medicine, CHR Mons-Hainaut, Mons, Belgium.
Background: Activation of the triggering receptor expressed on myeloid cells-1 (TREM-1) pathway is associated with septic shock outcomes. Data suggest that modulation of this pathway in patients with activated TREM-1 might improve survival. Soluble TREM-1 (sTREM-1), a potential mechanism-based biomarker, might facilitate enrichment of patient selection in clinical trials of nangibotide, a TREM-1 modulator.
View Article and Find Full Text PDFJ Mol Endocrinol
June 2010
Institut Cochin, Université Paris Descartes, CNRS (UMR 8104) INSERM, U567 Service d'Endocrinologie, Groupe Hospitalier Cochin-St-Vincent de Paul, 27 rue du Fg Saint-Jacques, 75014 Paris, France.
Various types of protein kinase A (PKA) alterations have been observed in adrenocortical tumours and Carney complex (CNC). PKA is a heterotetramer of two regulatory and two catalytic subunits. The R1A and R2B proteins are the most abundant regulatory subunits in endocrine tissues.
View Article and Find Full Text PDFProg Urol
February 2009
Service d'urologie, hôpital Cochin, groupe hospitalier Cochin St-Vincent-de-Paul, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France.
Objective: The aim of the study was to compare ureteroileal anastomosis strictures rates in patients receiving either double J stent or open-ended ureteral stent, after bladder replacement for cancer.
Methods: Medical charts from 75 patients who underwent cystectomy and Z pouch bladder substitution for bladder cancer, between 2001 and 2005, were retrospectively reviewed. Ureteroileal anastomosis was direct, spatulated end-to-side fashioned in all patients.
J Radiol
February 2007
Service de Radiologie, Groupe Hospitalier Cochin-St-Vincent-de-Paul-La-Roche-Guyon, Hôpital St-Vincent-de-Paul, 82 avenue Denfert Rochereau, 75674 Paris Cedex 14. Electronic address:
Ann Oncol
January 2007
Department of Medical Oncology, Groupe Hospitalier Cochin St Vincent de Paul, Université Paris 5, Assistance Publique-Hôpitaux de Paris, Paris, France.
Background: We hypothesized that cancer-related inflammation might increase the risk of febrile neutropenia (FN) induced by docetaxel (DCX, Taxotere), by both affecting the exposure to DCX and the tissue sensitivity.
Patients And Methods: Advanced cancer patients with normal liver function, performance status (PS)<3, were included. Cytochrome P450 3A (CYP 3A) activity was estimated before the first cycle of DCX by a single determination of midazolam plasma concentration, 4 hours after 0.
Clin Pharmacol Ther
June 2006
Ecole Pratique des Hautes Etudes, Pharmacologie, Faculté de Médecine, Groupe Hospitalier Cochin St Vincent de Paul, AP-HP, Université Paris-Descartes, Paris, France.
Objective: Patients initiating docetaxel chemotherapy were genotyped for CYP3A4, CYP3A5, MDR1, GSTM1, GSTT1, GSTM3, and GSTP1 to identify variability factors of docetaxel pharmacokinetics and toxicity.
Methods: Genotyping was performed by direct sequencing (CYP3A4), real-time polymerase chain reaction (CYP3A5), and polymerase chain reaction-restriction fragment length polymorphism (MDR1 and GST). The clearance and area under the curve of docetaxel were calculated by use of a Bayesian approach.
Infect Control Hosp Epidemiol
June 2006
Service de Sante Publique, Groupe Hospitalier Cochin-St. Vincent de Paul, Paris, France.
The objective of the present study was to evaluate the feasibility of azithromycin prophylaxis with respect to tolerability and compliance during a pertussis outbreak among healthcare workers in a university hospital ward. Compliance with the prophylaxis regimen was 89%; compliance was 75% from intent-to-treat perspective. The rate of adverse events was 33%.
View Article and Find Full Text PDFDrug Metab Dispos
April 2006
Department of Pharmacology, Université Paris-Descartes, Faculté de Médecine, Groupe Hospitalier Cochin St. Vincent de Paul, Paris, France.
A metabolic interaction between stiripentol (STP), an anticonvulsant agent that inhibits the activity of several cytochromes P450 (P450s), and clobazam (CLB), a 1,5-benzodiazepine, used in association with STP in severe myoclonic epilepsy in infancy was observed in vivo. This interaction was characterized in vitro using cDNA-expressed CYP3A4 and CYP2C19 (main P450 involved in CLB metabolism) to calculate K(i) and IC(50) of stiripentol in comparison with ketoconazole (CYP3A4 inhibitor) and omeprazole (CYP2C19 inhibitor). STP inhibited N-demethylation of CLB to N-desmethylclobazam (NCLB) mediated by CYP3A4 (noncompetitively) and CYP2C19 (competitively) with K(i) = 1.
View Article and Find Full Text PDFEur J Paediatr Neurol
July 2004
Service de gynécologie obstétrique, Groupe hospitalier Cochin-St Vincent de Paul. Maternité Port-Royal Baudelocque, Paris, France.
Unlabelled: BACKGROUND. The preterm infant is subject to the force of gravity: when its body lies pressed against the mattress on which it is placed.
Aims: The purpose of this study was to investigate short-term effects of varied post-natal lying positions in order to prevent neuromuscular and postural abnormalities.
Rev Prat
May 2002
Consultation de pédiatrie, groupe hospitalier Cochin-St-Vincent de Paul, 75674 Paris.
Bull Acad Natl Med
November 2000
Service du S.A.U., Groupe Hospitalier Cochin-St Vincent de Paul, Paris.
Emergency care are now restructuring in France. The role of emergency departments is defined by new regulations. They include the closure of small emergency rooms and definition of three levels for the others.
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