1 results match your criteria: "formally Seattle Biomedical Research Institute[Affiliation]"
Liver macrophage-associated inflammation correlates with SIV burden and is substantially reduced following cART.
PLoS Pathog
February 2018
Center for Infectious Disease Research, formally Seattle Biomedical Research Institute, Seattle, Washington, United States of America.
Article Synopsis
- Liver disease significantly impacts individuals with HIV, even with combination antiretroviral therapy (cART), but the underlying mechanisms remain unclear due to challenges in human sample collection and confounding factors like co-infections.
- A study using SIV-infected macaques found that untreated infection led to increased levels of liver macrophages and various inflammatory mediators, indicating a strong immune response linked to liver inflammation.
- In macaques receiving cART, there were reduced levels of liver macrophages and inflammation, but residual SIV DNA and bacterial DNA suggest ongoing immune activation in the liver despite treatment.