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Characterization of serum anti-diphtheria antibody activity following administration of equine anti-toxin for suspected diphtheria.

Hum Vaccin Immunother

November 2017

f MassBiologics of the University of Massachusetts Medical School, Boston , MA , USA.

Heidi L Smith Greg Saia Maria Lobikin Tejpratap Tiwari Su-Chun Cheng

There is a global shortage of equine-derived diphtheria anti-toxin (DAT) for diphtheria treatment. There are few existing data on serum antibody concentrations and neutralizing activity post-treatment to support development of new therapeutics. Antibody concentrations were quantified by ELISA and anti-toxin neutralizing activity by cytotoxicity assay in serum from 4 patients receiving DAT for suspected diphtheria.

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