Nasopharyngeal, tongue and laryngeal cancer in Southern Ethiopia: a seven-year retrospective cross-sectional review.

Background: The burden of cancer is increasing globally and is having a negative impact on people's physical, mental and financial health. On the other hand, developing countries are not progressing to prevent the disease at the same rate as the disease burden increases. The development of strategies for cancer prevention, control and treatment that contribute to the community's improved health requires knowledge of cancer epidemiologic data.

Prevalence of clinical malaria and associated symptoms in pregnant women at Hamusit health center, Northwest Ethiopia.

Background: Malaria is the disease caused by intracellular parasites known as species and is mainly transmitted by blood sucking female mosquitoes. During pregnancy, malaria results in severe complications to the mother, the fetus and the newborn. Symptoms of malaria, such as fever, malaise, headache, nausea and vomiting, in pregnant women can be mistakenly attributed solely to pregnancy.

Diagnostic Challenges and Insights Into Granulomatous Mastitis: A Systematic Review.

Granulomatous mastitis (GM) is a chronic inflammatory breast condition that presents significant diagnostic challenges due to its clinical and imaging similarities to malignancies. Accurate diagnosis is crucial to avoid unnecessary interventions and ensure effective management. A total of 1,216 articles were initially identified through a comprehensive database search.

Resistance mechanisms to immune checkpoint inhibitors: updated insights.

The last decade has witnessed unprecedented succusses with the use of immune checkpoint inhibitors in treating cancer. Nevertheless, the proportion of patients who respond favorably to the treatment remained rather modest, partially due to treatment resistance. This has fueled a wave of research into potential mechanisms of resistance to immune checkpoint inhibitors which can be classified into primary resistance or acquired resistance after an initial response.

Kinesiophobia and associated factors among people with musculoskeletal disorders in Ethiopia: a multicenter cross-sectional study.

Introduction: Kinesiophobia has a major health impact on patients with Musculoskeletal disorders (MSDs) in their functional and physical activities, which leads to poor outcomes, loss of motivation, loss of mobility, and decreased quality of life. Despite the burden of kinesiophobia among MSDs, there is limited evidence about the burden of kinesiophobia in Ethiopia. Thus, this study aimed to assess the prevalence and its associated factors of kinesiophobia among MSD patients attending physiotherapy outpatient clinics.

Prevalence and determinants of unhealthy feeding practices among young children aged 6-23 months in five sub-Saharan African countries.

Introduction: Despite the World Health Organization's advice against unhealthy feeding, many low- and middle-income countries, including sub-Saharan Africa (SSA) countries, are experiencing a nutritional transition to high in sugar, unhealthy fats, salts, and processed carbohydrates for younger children. However, there is a scarcity of recently updated multicounty information on unhealthy feeding practices and determinants in SSA countries. Therefore, this study aimed to assess the pooled prevalence of unhealthy feeding practices and determinants among children aged 6-23 months in five SSA countries.

Prevalence of body image dissatisfaction and associated factors among high school adolescent in Hawassa city, Ethiopia.

Background: Adolescence is a period in which individuals are more concerned with their body image. However, little is known about the prevalence of body image dissatisfaction and its associated factors. Thus, this study aimed to assess the prevalence of body image dissatisfaction and associated factors among high school adolescents in Hawassa city in 2023.

Peripheral blood biomarkers as differential diagnostic markers of disease severity in neonates with hyperbilirubinemia.

Background: Blood biomarkers offers an independent insight for the pathophysiology of hyperbilirubinemia. However, they are not practically used for the differential diagnosis of the hyperbilirubinemia severity. Therefore, the current study aimed to assess the differential diagnostic value of peripheral blood biomarkers with disease severity as an alternative.

Knowledge of obstetric fistula and contributing factors among reproductive-age women in Ethiopia: a systematic review and meta-analysis.

Introduction: Obstetric fistulas are one of the most severe injuries resulting from prolonged, obstructed labor, particularly when timely medical care is unavailable. In Ethiopia, numerous women and girls continue to endure the consequences of obstetric fistula due to contributing factors like early marriage and limited access to skilled healthcare during childbirth. The development of prevention strategies remains challenging, as reports on the knowledge surrounding obstetric fistulas and their causes are inconsistent across the country.

Prevalence and associated factors of malaria among the displaced population in refugee camps in Africa: a systematic review and meta-analysis.

Background: The increased occurrence of malaria among Africa's displaced communities poses a new humanitarian problem. Understanding malaria epidemiology among the displaced population in African refugee camps is a vital step for implementing effective malaria control and elimination measures. As a result, this study aimed to generate comprehensive and conclusive data from diverse investigations undertaken in Africa.

Benefits, challenges, and best practices of collaborative partnerships among health supply chain stakeholders in Rwanda: a cross-sectional study.

Background: Strong partnerships, community engagement, and multisectoral collaboration in the health supply chain are synergistic pillars towards achieving universal health coverage. In Rwanda, the health supply chain involves the collaboration of various stakeholders, including distributors, manufacturers, wholesalers, and customers. However, since the eruption and ending of COVID-19, there has not been any study to assess stakeholders' perspectives on the status of the benefits, challenges, and best practices of collaborative partnerships among health supply chain stakeholders in Rwanda.

High-risk fertility behavior and associated factors among mothers attending antenatal care at public health facilities in Hossana Town, Central Ethiopia Region: facility based cross sectional study.

Background: High-risk fertility behavior (HRFB) is a serious public health issue that may influence the country's economic development as well as the health status of mothers mainly in developing countries, like Ethiopia.However, there is a scarcity of evidence about HRFB and associated factors in the study area. Therefore, this study assessed HRFB and associated factors among mothers attending antenatal care in public health facilities in Hossana town, Hadiya zone, Central Ethiopia Region.

Liver oval cells in response to HDAC1 inhibitor trichostatin A: immunohistochemical characterization using OV-6 hepatic expression.

Liver regeneration is intricate, involves many cells, and necessitates extended research. This study aimed to investigate the response of liver oval cells (bipotent liver progenitors) to the epigenetic modifier trichostatin A (TSA), an HDAC1 inhibitor, and to develop a scoring system for assessing the response of these cells. Three groups of equally divided rats (n=24) were selected: control (A, dimethyl sulfoxide treated); oval cell induction (B, acetylaminofluorene [2-AAF] to block hepatocyes/carbon tetrachloride [CCL4] to induce oval cell response); and epigenetic modulation (C, TSA post 2-AAF/CCL4 injury).

Factors associated with defensive medicine practice in United Arab Emirates: A cross-sectional study with multivariate analysis.

Health services institutes worldwide are trying to reduce defensive medical practice to limit its negative impact on patient care. We evaluated the factors associated with this defensive medical practice among medical professionals in the United Arab Emirates. This study deployed multivariate logistic regression analysis.

Biallelic variants in AGRN with recurrent pregnancy losses in a family with a fetal akinesia deformation sequence.

Introduction: Agrin, encoded by AGRN, plays a vital role in the acetylcholine receptor clustering pathway, and any defects in this pathway are known to cause congenital myasthenic syndrome (CMS) 8 in early childhood with variable fatigable muscle weakness. The most severe or lethal form of CMS manifests as a fetal akinesia deformation sequence (FADS). To date, only one family has been reported with an association of null variants in AGRN and a lethal FADS.

Paradoxical Inflammatory Bowel Disease Induced by Golimumab in a Patient With Ankylosing Spondylitis: A Case Report and Systematic Review.

Paradoxical reactions (PRs) to biologic medications, such as psoriasis, arthritis, and inflammatory bowel disease (IBD), have been increasingly recognized. The aim of reporting this case is to establish an association between golimumab and exacerbation or new (de novo) IBD in patients with axial spondyloarthritis (SpA). Our case involves a young patient with juvenile-onset ankylosing spondylitis (AS) who developed de novo IBD following golimumab therapy for active spinal disease.

Breaking New Ground: A Seropositive Neuromyelitis Optica (NMOSD) in Ethiopian Patients: A Case Series.

This case series highlights the diverse presentations of seropositive neuromyelitis optica spectrum disorder, including the absence of optic neuritis despite anti-aquaporin 4 antibody positivity. It emphasizes the importance of high index of suspicion, early neurologist referral for improved outcomes, the consequences of delayed referral, and the challenges and treatment potential in low-income countries with limited resources.

Recent advances in HPV biotechnology: understanding host-virus interactions and cancer progression - a review.

Cervical cancer ranks as the fourth most common cancer among women globally, posing a significant mortality risk. Persistent infection with high-risk human papillomavirus (HPV) is the primary instigator of cervical cancer development, often alongside coinfection with other viruses, precipitating various malignancies. This study aimed to explore recent biotechnological advances in understanding HPV infection dynamics, host interactions, and its role in oncogenesis.

Male involvement in antenatal care follow-up and its determinants in Ethiopia: a systematic review and meta-analysis.

Objective: To determine the involvement of males in antenatal care (ANC) follow-up and its determinants in Ethiopia.

Design: A systematic review and meta-analysis.

Data Sources: A systematic search was done on PubMed, African Journals Online, HINARI, ScienceDirect, Google Scholar and direct Google up to 20 November 2023.

Prevalence, spatial variation and associated factors of mixed milk feeding among mothers with infants aged 0-6 months in Ethiopia: a spatial and multilevel analysis.

Objective: This study aimed to determine the prevalence, spatial variation and associated factors of mixed milk feeding practice among mothers with infants aged 0-6 months in Ethiopia.

Study Design: A cross-sectional study design was used.

Setting: The study was conducted in Ethiopia.

SARS-CoV-2 excretion and genetic evolution in nasopharyngeal and stool samples from primary immunodeficiency and immunocompetent pediatric patients.

Background: Primary Immunodeficiency disorders (PID) can increase the risk of severe COVID-19 and prolonged infection. This study investigates the duration of SARS-CoV-2 excretion and the genetic evolution of the virus in pediatric PID patients as compared to immunocompetent (IC) patients.

Materials And Methods: A total of 40 nasopharyngeal and 24 stool samples were obtained from five PID and ten IC children.

Delays in health care seeking for diarrheal disease and associated factors among caregivers of under five children in health centers of northwest Ethiopia: a mixed-method study.

Background: Approximately 70% of child deaths due to diarrhea are caused by a lack of timely healthcare. However, there was little evidence of factors associated with delays in seeking health care for patients with diarrheal diseases in the study area. Therefore, this study aimed to investigate delays in seeking healthcare for children with diarrhea and identify associated factors among caregivers in health centers of Northwest Ethiopia.

Consequence of War on Diabetic Mellitus patients in Tigray region, Ethiopia: a longitudinal study.

Background: Studies of the world health organization indicated that Diabetes is on the rise. The occurrence of diabetes is steadily increasing everywhere, most markedly in the world's middle and low-income countries. The aim of this study is to explore the consequence of war on the sugar level of diabetic mellitus patients.