147 results match your criteria: "centre hospitalier universitaire pédiatrique Charles-de-Gaulle[Affiliation]"

The dressing is an important element in the management of severe burns. The aim of this study was to present the results of the dressing in room air and peanut oil. This was a descriptive retrospective study conducted from January 1, 2014 to December 31, 2020 in the surgery department of the Dédougou regional hospital center.

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What is the lower limb length discrepancy after arthroplasty for proximal femoral fracture? A prospective, multicenter observational study of 590 hips.

Orthop Traumatol Surg Res

December 2024

Société Française de Chirurgie Orthopédique et Traumatologique, 56 rue Boissonade, 75014 Paris Cedex, France.

Introduction: Lower limb length discrepancy (LLD) following hip arthroplasty after proximal femoral fracture (PFFA) is little studied. The aim of this work was to answer the following questions: 1) What are the incidence and mean values ​​of LLD after PFFA? 2) What are the clinical consequences (tolerance) of LLD after PFFA? 3) Can we identify risk factors for LLD after PFFA? 4) Is there a significant difference in terms of LLD after PFFA to treat intra- versus extra-capsular fractures?

Hypothesis: LLD after proximal femoral fracture arthroplasty is rare but has good clinical tolerance, given the low functional demands of the patients.

Patients And Methods: This is a multicenter prospective observational cohort study (15 centers), including 590 patients, operated on for hip arthroplasty for proximal femur fracture between May 2022 and June 2023.

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Article Synopsis
  • The phase III KEYNOTE-913 study focused on assessing the effectiveness and safety of pembrolizumab as a first-line treatment for advanced Merkel cell carcinoma (MCC).
  • Results indicated a 49% objective response rate among the 55 patients treated, with a median duration of response of 39.8 months and median overall survival of 24.3 months.
  • The treatment showed manageable side effects, with 69% of patients experiencing any grade adverse events, but only 24% facing severe issues, highlighting pembrolizumab's potential in this patient group.
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Background: Awareness of one's own states is a particularly important part of cognition and emotion regulation. Recently, the concept of alexisomia has been used to refer to lack of awareness and expression of somatic sensations. Developing self-reported questionnaires to evaluate alexisomia represents a challenge for clinical psychology and medicine.

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Prognostic impact of high-intensity lipid-lowering therapy under-prescription after acute myocardial infarction in women.

Eur J Prev Cardiol

November 2024

Department of Cardiology, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Européen Georges Pompidou (HEGP), 20 rue Leblanc, 75015 Paris, France.

Aims: Women are less likely to receive lipid-lowering therapy (LLT) after acute myocardial infarction (AMI). We analysed whether this under-prescription currently persists and has an impact on long-term outcomes.

Methods And Results: The FAST-MI programme consists of nationwide registries including all patients admitted for AMI ≤ 48 h from onset over a 1 month period in 2005, 2010, and 2015, with long-term follow-up.

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Urea Level and Depression in Patients with Chronic Kidney Disease.

Toxins (Basel)

July 2024

Centre for Research in Epidemiology and Population Health (CESP), Clinical Epidemiology Team, Inserm U1018, Paris-Saclay University, 12 Avenue Paul Vaillant Couturier, F-94800 Villejuif, France.

Article Synopsis
  • * In a cohort of 2505 CKD patients, researchers found that while urea levels did not significantly predict new antidepressant prescriptions, higher urea was linked to worsening depressive symptoms over a 5-year follow-up.
  • * The findings suggest a connection between serum urea levels and depression symptoms, highlighting the need for further research to clarify the mechanisms involved.
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Purpose: Respiratory dysfunction is one of the most frequent symptoms observed during sepsis reflecting hypoxemia and/or acidosis that may be assessed by the ROX index (ratio of oxygen saturation by pulse oximetry/fraction of inspired oxygen to respiratory rate). This study aimed to describe the relationship between the prehospital ROX index and 30-day mortality rate among septic shock patients cared for in the prehospital setting by a mobile intensive care unit (MICU).

Methods: From May 2016 to December 2021, 530 septic shock patients cared for by a prehospital MICU were retrospectively analysed.

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[Factor XI deficiency: actuality and review of the literature].

Ann Biol Clin (Paris)

June 2024

Laboratoire d'Hématologie, CHU d'Angers, 4 rue Larrey, 49100 Angers.

Although two clusters have been identified in France, constitutional factor XI deficiency is a rare disorder. Acquired factor XI deficiency is extremely rare. The management of factor XI deficiency is not staightforward because of the unpredictable bleeding tendency that does not clearly relate to the factor XI level.

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Article Synopsis
  • - Secondary bacterial infections commonly occur in skin conditions like atopic dermatitis, ectoparasitosis, and varicella zoster, primarily involving Staphylococcus aureus and Streptococcus pyogenes, with occasions of Gram-negative infections as well.
  • - Factors that promote these infections include changes to the skin barrier, itchiness, and specific environmental influences, which can vary based on the patient's location and the type of dermatosis.
  • - Effective prevention and treatment hinge on managing the underlying skin condition, maintaining proper skin hygiene, and in cases of recurrence, addressing S. aureus colonization.
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Epidemiological, clinical, diagnostic, and therapeutic features of histoplasmosis: A systematic review.

J Mycol Med

June 2024

Service de parasitologie-mycologie, Centre Hospitalier Universitaire Souro Sanou, 01 BP 676 Bobo-Dioulasso 01, Burkina Faso; Institut des Sciences de la Santé, Université Nazi Boni (UNB), 01 BP 1091 Bobo-Dioulasso 01, Burkina Faso.

Article Synopsis
  • - Histoplasmosis is a fungal infection caused by Histoplasma capsulatum, and this study reviews its epidemiological, clinical, diagnostic, and treatment aspects over the past 30 years through a comprehensive literature search.
  • - Between 1992 and 2021, 190 publications reported 212 cases of histoplasmosis, with a significant increase in cases noted in the last decade, particularly in 2020, and disseminated forms being more common than localized ones in both American and African cases.
  • - Itraconazole and Amphotericin B are the most frequently used treatments, and while American histoplasmosis is found globally, African histoplasmosis is mainly present in intertropical Africa; there is a
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Background: The early identification of sepsis presenting a high risk of deterioration is a daily challenge to optimise patient pathway. This is all the most crucial in the prehospital setting to optimize triage and admission into the appropriate unit: emergency department (ED) or intensive care unit (ICU). We report the association between the prehospital National Early Warning Score 2 (NEWS-2) and in-hospital, 30 and 90-day mortality of SS patients cared for in the pre-hospital setting by a mobile ICU (MICU).

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Article Synopsis
  • Ventilator associated pneumonia (VAP) caused by wild-type AmpC-producing Enterobacterales is common in ICU patients, and the study explores the effectiveness of different antimicrobial therapies (AMT), specifically piperacillin ± tazobactam (PTZ) and third-generation cephalosporins (3GCs).
  • In a study involving 274 ICU patients, no significant differences in treatment success at day 7 were found between the groups receiving PTZ, 3GCs, or other control treatments, with all groups showing success rates around 68-74%.
  • However, patients treated with 3GCs had a higher likelihood of pneumonia recurrence by day 28 compared to those on PTZ
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Background: Gender imbalance and poor representation of women complicate the anesthesiology workforce crisis in sub-Saharan Africa (SSA). This study was performed to obtain a better understanding of gender disparity among medical graduates and anesthesiologists in SSA.

Methods: Using a quantitative, participatory, insider research study, led by female anesthesiologists as the national coordinators in SSA, we collected data from academic or national health authorities and agencies.

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Scapulothoracic dissociation due to a trauma is exceptional. The purpose of this study was to share our experience with a case of scapulothoracic dissociation and to explain the advantages of our approach. We report the case of a 12-year-old right-handed schoolgirl admitted to hospital with a blunt trauma to the right thoracic limb complicated by infection after a week of traditional treatment (massage, bandaging with reed splints).

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Unlabelled: Tonsillar tuberculosis is the infectious localization of Koch's bacillus in the palatine tonsils. It is rare. Tonsillar tuberculosis associated with miliary tuberculosis is even more exceptional.

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Capnography-An Essential Monitor, Everywhere: A Narrative Review.

Anesth Analg

November 2023

Department of Anaesthesia and Intensive Care, Manchester Royal Infirmary, United Kingdom.

Capnography is now recognized as an indispensable patient safety monitor. Evidence suggests that its use improves outcomes in operating rooms, intensive care units, and emergency departments, as well as in sedation suites, in postanesthesia recovery units, and on general postsurgical wards. Capnography can accurately and rapidly detect respiratory, circulatory, and metabolic derangements.

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Article Synopsis
  • Intermittent preventive treatment with sulfadoxine-pyrimethamine for malaria in pregnant women is crucial in Burkina Faso, but resistance to the drug needs further investigation due to insufficient data on genetic mutations.
  • A study conducted from April 2019 to March 2020 analyzed placentas from postpartum women in Ouagadougou to assess genetic diversity and mutation prevalence in malaria-causing parasites.
  • Findings revealed high rates of PCR-positive samples, widespread allelic families, and certain genetic mutations, indicating potential early warning signs for increasing resistance to sulfadoxine-pyrimethamine in the population.
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Background: Septic shock medical treatment relies on a bundle of care including antibiotic therapy and hemodynamic optimisation. Hemodynamic optimisation consists of fluid expansion and norepinephrine administration aiming to optimise cardiac output to reach a mean arterial pressure of 65mmHg. In the prehospital setting, direct cardiac output assessment is difficult because of the lack of invasive and non-invasive devices.

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Background: A low-level risk of intussusception following rotavirus vaccination has been observed in some settings and may vary by vaccine type. We examined the association between RotaTeq vaccination and intussusception in low-income settings in a pooled analysis from 5 African countries that introduced RotaTeq into their national immunization program.

Methods: Active surveillance was conducted at 20 hospitals to identify intussusception cases.

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Guidelines on perioperative optimization protocol for the adult patient 2023.

Anaesth Crit Care Pain Med

August 2023

Department of Anaesthesiology and Critical Care, Beaujon Hospital, DMU Parabol, AP-HP, Nord, Clichy, France; University of Paris, Paris, France; Inserm UMR_S1149, Centre for Research on Inflammation, Paris, France.

Objective: The French Society of Anesthesiology and Intensive Care Medicine [Société Française d'Anesthésie et de Réanimation (SFAR)] aimed at providing guidelines for the implementation of perioperative optimization programs.

Design: A consensus committee of 29 experts from the SFAR was convened. A formal conflict-of-interest policy was developed at the outset of the process and enforced throughout.

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Introduction: Personal protective equipment (PPE) is used by health care workers to protect themselves and patients from various exposures such as infectious agents. However, the wearing of this equipment is not always optimal, especially in an epidemic context of COVID-19 transmission.

Aim Of The Study: The aim of this study, in the specific context of COVID-19, is to contribute to the improvement of PPE wearing practices by health workers.

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A detailed overview of the basic science and clinical literature reporting on the challenges for the optimization of reverse shoulder arthroplasty (RSA) is presented in two review articles. Part I looks at (I) external rotation and extension, (II) internal rotation and the analysis and discussion of the interplay of different factors influencing these challenges. In part II, we focus on (III) the conservation of sufficient subacromial and coracohumeral space, (IV) scapular posture and (V) moment arms and muscle tensioning.

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