[Neuro-Behçet in a Sub-Saharan Africa Country: a Series of Sixteen Patients in Fann Teaching Hospital, Dakar, Senegal].

Neuro-Behçet (NB) African studies are mainly North African, but Sub-Saharan Africa is not to be outdone. Our aim was to describe diagnostic and therapeutic features of NB in a Senegalese series collected in Dakar. This was a descriptive and retrospective study conducted at the Neurology department of Fann Teaching Hospital in Dakar, Senegal.

[Inverted papilloma: a study of 13 cases in the Oto-Rhino-Laryngology at the National University Hospital of Fann].

Introduction: Inverted Papilloma (IP) is a rare benign tumour of the nose and paranasal sinuses histologically characterized by invagination of the outer layer of the epithelium in the underlying chorion. Its most distinctive feature is a strong local aggressiveness, a tendency to recur and an unpredictable risk of association with epidermoid carcinoma. The purpose of this study was to report the epidemiological, clinical, paraclinical data as well as to assess the outcomes of endoscopic endonasal surgery.

[Update on intrasellar arachnoid cyst: a case study].

Intrasellar arachnoid cysts are benign malformations. They are extremely rare (approximately 3% of cases). Their pathophysiology is still poorly elucidated.

[Smoking in People Living with HIV (PLHA) and followed up in the Outpatient Department of the Hospital Fann of Dakar].

Introduction: PLHA who smoke have twice the never-smoker mortality rate and have an increased risk of developing non-AIDS diseases. The prevalence of tobacco smoking is higher among PLHA than in the general population. The purpose of this study was to assess the prevalence of smoking among PLHA, to describe the clinical and spirometric features of smokers and ex-smokers and to assess their knowledge and attitudes toward smoking.

Affordable Custom Three-Dimensional Anatomy Atlases.

In this paper, we present methodology and tools for creating custom three-dimensional anatomical atlases for medical education based on web technologies and open-source software. Traditional medical anatomy education has relied on printed anatomical atlases, in-person lectures, and anatomical dissection. This traditional approach underserves populations in need due to high cost, lack of availability of materials, and a limited of trained educators.

Nutrition support for HIV-TB co-infected adults in Senegal, West Africa: A randomized pilot implementation study.

Background: Food insecurity can contribute to poor adherence to both tuberculosis treatment and HIV antiretroviral therapy (ART). Interventions that target food insecurity have the potential to increase treatment adherence, improve clinical outcomes, and decrease mortality. The goals of this study were to compare the feasibility, acceptability, and potential impact of implementing two different forms of nutrition support for HIV-TB co-infected adults in the Casamance region of Senegal.

[Intestinal tuberculosis revealed by acute bowel obstruction during paradoxical reaction to antituberculosis treatment in an immunocompetent patient: about a case and literature review].

Abdominal tuberculosis accounts for 3 to 5% of all visceral diseases. Despite the demonstrated effectiveness of anti-tuberculosis treatments, some cases of exacerbation of the initial clinical presentation have been described during the initiation of treatment. However, these reactions also known as "paradoxical" have been rarely reported in immunocompetent patients and much less in the case of bowel obstruction.

Traditional healers, HIV outcomes, and mortality among people living with HIV in Senegal, West Africa.

Objectives: The goals of this study were to determine the frequency of traditional healer use among people living with HIV in Senegal, to identify predictors of traditional healer use, and to determine if traditional healer use is associated with HIV outcomes.

Design: Prospective longitudinal study.

Methods: Participants were enrolled from April 2017 to April 2018 in Dakar and Ziguinchor, Senegal.

[Indications and results of surgical resection of bubbles arising from pulmonary emphysema].

Surgical resection of bubbles or bullectomy is the gold standard in the treatment of bubbles arising from pulmonary emphysema. It is usually indicated for patients with complicated bubbles or when they are the underlying cause of disabling dyspnea. This study aims to determine the indications for bullectomy and to evaluate surgical outcomes in our Department.

[Radiological features of microscopy-positive pulmonary tuberculosis in patients in the Pneumology Department at the National University Hospital, Fann, Dakar (Sénégal)].

This study aimed to determine the radiological features of microscopy-positive pulmonary tuberculosis (TB). We conducted a retrospective study, analyzing radiographical imaging of patients with microscopy-positive pulmonary tuberculosis between 15 November 2015 and 15 March 2016. The medical records of 66 patients meeting the inclusion criteria were selected, 81.

A Trial of a Single-tablet Regimen of Elvitegravir, Cobicistat, Emtricitabine, and Tenofovir Disoproxil Fumarate for the Initial Treatment of Human Immunodeficiency Virus Type 2 Infection in a Resource-limited Setting: 48-Week Results From Senegal, West Africa.

Background: There is an urgent need for safe and effective antiretroviral therapy (ART) for human immunodeficiency virus type 2 (HIV-2) infection. We undertook the first clinical trial of a single-tablet regimen containing elvitegravir, cobicistat, emtricitabine, and tenofovir disoproxil fumarate (E/C/F/TDF) to assess its effectiveness in HIV-2-infected individuals in Senegal, West Africa.

Methods: HIV-2-infected, ART-naive adults with World Health Organization stage 3-4 disease or CD4 count <750 cells/μL were eligible for this 48-week, open-label trial.

[Narrow lumbar channel due to epidural lipomatosis: case report and literature review].

Epidural lipomatosis is characterized by the abnormal accumulation of non-encapsulated grease in the epidural space. Although rare, it is a possible cause of lombosciatica or narrow lumbar channel. It is often associated with contributing factors such as prolonged corticosteroid therapy or obesity.

[Occult hepatitis B reactivation in a patient with homozygous sickle cell disease: clinical case and literature review].

Occult Hepatitis B corresponds to the presence of hepatitis B virus-deoxyribonucleic acid (HBV-DNA) in serum and/or in liver of a patient despite HBsAg negativity. Clinically, it is usually asymptomatic. Its reactivation is rare and commonly occurs in immunosuppressed individuals.

[DRESS syndrome secondary to pyrazinamide: An uncommon complication of tuberculosis treatment].

Introduction: The Drug Reaction with Eosinophilia and Systemic Symptom (DRESS) is a severe drug-induced reaction.

Case Report: We report the case of a 35-year-old man treated by RHEZ for a first episode of a smear positive pulmonary tuberculosis and who developed a DRESS syndrome due to pyrazinamide after twenty days of treatment, associated with a viral reactivation to Human Herpes Virus 6 (HHV6). He had a skin eruption, liver involvement and hypereosinophilia.

[Clinical and radiological characteristics of pulmonary tuberculosis in tobacco smokers].

Introduction: Tobacco smoke alters lung defense mechanisms against infections and so increases the risk of mycobacterium tuberculosis infection.

Objective: To determine the particular clinical features of tuberculosis in smokers and identify risk factors.

Methods And Patients: We conducted a prospective, cross-sectional study over a period of nine months in Dakar, Senegal.

[TB/HIV co-infection associated with Kaposi's sarcoma under opioid substitution treatment using methadone: about a case].

Late diagnosis of HIV infection can be fatal because it favors the appearance of opportunistic infections whose management requires the use of several molecules which can cause drug interactions. We report the case of a 45-year old female patient under heroin substitution treatment, using methadone and with HIV1 under antiretroviral treatment. This patient had nonspecific pulmonary appearance associated with dry nagging cough and progressive dyspnea evolving in a feverish context.

[Therapeutic itinerary and radiological features of positive microscopy tuberculosis patients at Centre Hospitalier National Universitaire de Fann (CHNUF), Dakar].

Introduction: The long diagnostic delay is responsible for the extension of radiological lesions and spread of TB in the community. These radiological lesions can leave significant scars responsible for respiratory disability.

Objective: The aim of the study is to characterize radiologic features according to tuberculosis diagnostic delay.

[Rituals of birth in Senegal].

In a Senegalese society undergoing profound change, holding on to certain beliefs and social and cultural practices can sometimes prove difficult. Prevention and care systems must take into account social and cultural representations in order to support these families as best as possible.

[A typical shared psychotic disorder: about a case].

Shared psychotic disorder is a rare entity characterized by the transmission of delusional symptoms from one patient ("inducer") to another ("induced" partner). We here report a clinical observation of atypical shared psychotic disorder involving delusion of persecution and of grandeur in a teenager induced by two subjects (grand-father and paternal uncle) with two different types of psychiatric disorders, all of which present in the same subject (third-party). The nature of the content transmitted to the third subject was the sum of the ideas of the first two subjects.

Amplification of blood smear DNA to confirm disseminated histoplasmosis.

Background: The prevalence of the Histoplasma capsulatum var. capsulatum (Hcc) histoplasmosis may be underestimated West Africa, both because the diagnosis is not mentioned in the early stages of the disease and due to limited biological resources available.

Case Report: We report a case of disseminated histoplasmosis due to Hcc in a Senegalese HIV patient.

[Contribution of the Xpert MTB/RIF to the etiological diagnosis of tuberculous pleurisy].

Introduction: Performance of the Xpert MTB/RIF for the detection of Mycobacterium tuberculosis in pleural liquid is poorly described. The aim of this study was to determine its usefulness for the etiological diagnosis of a tuberculous pleurisy.

Patients And Method: We performed a descriptive cross-sectional study, with analytical design, including all the patients having a unilateral serofibrinous pleurisy, exudative, lymphocytic, and sterile.

Daily consumption of ready-to-use peanut-based therapeutic food increased fat free mass, improved anemic status but has no impact on the zinc status of people living with HIV/AIDS: a randomized controlled trial.

Background: Food insecurity in sub-Saharan Africa and malnutrition constitute the main obstacles for successful treatment of people living with HIV/AIDS (PLWH). The aim of this study was to assess the effect of consuming daily 100 g RUTF (ready-to-use therapeutic food) as supplement, on body composition, anemia and zinc status of hospitalized PLWH in Senegal.

Methods: A Controlled clinical trial was conducted in 65 PLWH randomly allocated to receive either standard hospital diet alone (Control group: n = 33), or the standard diet supplemented with 100 g RUTF/day (RUTF group: n = 32).

Giant Arteriovenous Malformation of the Neck.

Arteriovenous malformations (AVM) have a wide range of clinical presentations. Operative bleeding is one of the most hazardous complications in the surgical management of high-flow vascular malformations. In the cervical region, the presence of vital vascular structures, such as the carotid artery and jugular vein, may increase this risk.

Epidemiology and genetic characterization of measles strains in Senegal, 2004-2013.

Background: In Senegal, with the variable routine vaccination coverage, the risk for illness and death from measles still exists as evidenced by the measles epidemic episode in 2009. Since 2002 a laboratory-based surveillance system of measles was established by the Ministry of Health and the Institut Pasteur de Dakar. The present study analysed the data collected over the 10 years inclusive between 2004-2013 in order to define a measles epidemiological profile in Senegal, and we carried out a phylogenetic analysis of measles virus circulating in Senegal over the period 2009-2012.

Population structure of clinical Pseudomonas aeruginosa from West and Central African countries.

Background: Pseudomonas aeruginosa (PA) has a non-clonal, epidemic population with a few widely distributed and frequently encountered sequence types (STs) called 'high-risk clusters'. Clinical P. aeruginosa (clinPA) has been studied in all inhabited continents excepted in Africa, where a very few isolates have been analyzed.