103 results match your criteria: "centre hospitalier de Dunkerque[Affiliation]"

Introduction: This study assessed the influence of intrapersonal (one's own emotions) and interpersonal (emotions of others) emotional competence (EC) of informal caregivers on their quality of life (QoL) at the beginning of cancer care.

Methods: Participants completed two questionnaires assessing their intrapersonal and interpersonal EC (S-PEC) as well as their QoL (SF-36) at the beginning of treatments. Multivariate ANCOVA regression analyses were then performed to explore the influence of EC on QoL.

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Real-world data for marginal zone lymphoma patients in the French REALYSA cohort: The REALMA study.

Hematol Oncol

November 2024

Université Paris Cité, Assistante Publique Hôpitaux de Paris, Hôpital Saint-Louis, Service d'Hémato-Oncologie, Paris, France.

Marginal Zone Lymphoma (MZL) comprises three subtypes: extranodal MZL (EMZL), splenic MZL (SMZL) and nodal MZL (NMZL). Since clinical trials have limited representativeness, there is a need for real-world data (RWD) evidence in MZL. Real-world data in Lymphoma and survival in Adults (REALYSA) is a prospective multicentric French cohort of newly diagnosed lymphoma patients.

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Objectives: Avacopan, a selective C5aR1 inhibitor, recently emerged as a glucocorticoid (GCs) sparing agent in ANCA-associated vasculitis (AAV). We aim to evaluate the tolerance and efficacy of avacopan given outside randomized clinical trials or with severe kidney involvement.

Methods: In this multicentre retrospective study, we reviewed the clinical charts of patients with AAV and contraindication to high dose of GCs who received avacopan 30 mg b.

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The main objective was to assess the link between emotional competence (EC) and adjustment outcomes such as supportive care needs (SCN) and anxious-depressive symptoms in cancer patients starting chemotherapy. The second objective was to assess the interaction effect between EC and the COVID-19 pandemic (i.e.

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Long-term Outcome of Risankizumab in Crohn's Disease: a Real-world GETAID Study.

Clin Gastroenterol Hepatol

December 2024

Department of Gastroenterology, INFINY Institute, FHU-CURE, INSERM NGERE, Nancy University Hospital, Vandœuvre-lès-Nancy, France.

Background & Aims: The aim of this study was to assess the long-term effectiveness and safety of risankizumab maintenance treatment in a large real-world cohort of patients with Crohn's Disease (CD).

Methods: From May 2021 to August 2023, all consecutive patients with CD treated with risankizumab in 25 GETAID centers have been retrospectively included. The primary endpoint was steroid-free clinical remission (Harvey Bradshaw Index [HBI] <5) at 52 weeks.

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Purpose: To ensure the safe use of oral anticancer drugs, oncology pharmacy consultations (OPCs) have been established in France. They are conditioned by the needs, expectations, and involvement of the patients in their care. Thus, it is essential to elicit their preferences.

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Purpose: This cross-sectional study explored the associations between intrapersonal and interpersonal emotional competence (EC) and the unmet supportive care needs (SCN), anxiety, and depression of informal caregivers at the beginning of gastrointestinal or haematological cancer care, i.e. during chemotherapy and within 6 months after diagnosis.

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Clinical and functional outcomes of 405 Achilles tendon ruptures after a minimum follow-up of 1 year.

Orthop Traumatol Surg Res

September 2024

CERS, groupe Ramsay Santé, 83, avenue du Maréchal-de-Lattre-de-Tassigny, 40130 Capbreton, France.

Article Synopsis
  • This study aimed to compare the outcomes of surgical versus conservative treatments for acute Achilles tendon ruptures, focusing on complications, functional outcomes, and clinical results after at least one year of follow-up.
  • Researchers conducted a retrospective analysis involving 405 patients treated in France between 2018 and 2019, gathering data on demographics, treatment methods, rehabilitation, and various clinical tests.
  • The results showed that while rerupture rates were similar between both groups, conservative treatment had a higher overall complication rate, while certain functional outcomes favored surgical treatment.
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Background: Acute calcium pyrophosphate crystal arthritis causes intense joint pain mainly affecting older people. Because guidance and evidence remain scarce, management of this disease relies on expert opinion. We therefore aimed to compare the safety and short-term equivalence of low-dose colchicine with oral prednisone in older patients with acute calcium pyrophosphate crystal arthritis.

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[Local treatments for bullous pemphigoid].

Soins

November 2023

Service de dermatologie, centre hospitalier de Dunkerque, 103 avenue Louis-Herbeaux, 59385 Dunkerque, France; Service de dermatologie, centre de compétence maladies bulleuses auto-immunes, hôpital Claude- Huriez, rue Michel-Polonowski, 59037 Lille, France.

Bullous pemphigoid affects people who are usually very frail, because they are very old and frequently have neurological co-morbidities. Over the past twenty years, therapeutic management has improved thanks to the application of highly potent corticosteroid-based creams, following a well-established regimen, for several months. Well-conducted nursing care is therefore essential not only to cover wounds, but also to treat the disease.

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Article Synopsis
  • Real-world data (RWD) are crucial for enhancing clinical trial (CT) findings, but challenges like data quality persist; the REALYSA study, launched in 2018, focuses on newly diagnosed lymphoma patients in France.
  • A proof-of-concept analysis of 645 patients with diffuse large B-cell lymphoma (DLBCL) found high data completeness (<4% missing) and revealed good survival rates, with a median follow-up of 9.9 months showing 1-year event-free survival of 77.9% and overall survival of 90.0%.
  • The study also assessed how well REALYSA's patient outcomes matched those from recent phase 3 trials (POLARIX and SENIOR), demonstrating
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Background: The optimal duration of immune checkpoint inhibitor (ICI) treatment for patients with advanced non-small cell lung cancer (NSCLC) remains to be determined. Treatment durations in cornerstone phase 3 clinical trials vary between a fixed 2-year duration and pursuit until disease progression. Clinical practices may thus differ according to the attending physician.

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[Orbital septic emboli from endocarditis].

J Fr Ophtalmol

June 2023

CHRU de Lille, hôpital Claude Huriez, clinique d'ophtalmologie, rue Michel Polonowski, 59037 Lille, France.

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Background: Systemic treatment options for psoriasis are limited for patients with recent neoplasia.

Objectives: We report the real-life use of apremilast (APR) in patients with psoriasis and recent cancer.

Materials & Methods: We conducted a retrospective, multicentre study in five hospitals and among 120 private dermatologists in the north of France from January 2015 to May 2021.

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Emotional distress, supportive care needs and age in the prediction of quality of life of cancer patients' caregivers: A cross-sectional study.

Eur J Oncol Nurs

June 2023

Univ. Lille, CNRS, UMR 9193 - SCALab - Sciences Cognitives et Sciences Affectives, F-59000, Lille, France; Human and Social Sciences Department - Centre Léon Bérard, Lyon, France; Université Claude Bernard Lyon 1, Centre de Recherche en Cancérologie de Lyon - UMR Inserm 1052 - CNRS 5286 - UCBL - CLB, Lyon, France. Electronic address:

Introduction: The existing literature shows a significant impact of cancer on caregivers' quality of life (QoL) and divergent results according to associated factors. To better understand the experience of cancer patients' caregivers, the present study aimed at comparing caregivers' QoL according to cancer care pathway and type of cancer, and at identifying the factors associated with their QoL.

Methods: Caregivers were included in the study either during chemotherapy or follow-up to assess their QoL (CARGOQoL), unmet supportive care needs (SCNS-P&C), and anxiety and depression levels (HADS).

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[Value of wide-field fundus photography for monitoring of acute retinal necrosis].

J Fr Ophtalmol

May 2023

CHU de Lille, clinique d'ophtalmologie, hôpital Claude-Huriez, rue Michel-Polonowski, 59037 Lille, France.

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Impact of central nervous system involvement in adult patients with Philadelphia-negative acute lymphoblastic leukemia: a GRAALL-2005 study.

Haematologica

December 2023

Maladies du Sang, CHU d'Angers, Angers, France; Federation Hospitalo-Universitaire Grand-Ouest Acute Leukemia, FHU-GOAL; Universite d'Angers, Inserm UMR 1307, CNRS UMR 6075, Nantes Universite, CRCI2NA, F-49000 Angers.

Whereas the prognosis of adult patients with Philadelphia-negative acute lymphoblastic leukemia (ALL) has greatly improved since the advent of pediatric-inspired regimens, the impact of initial central nervous system (CNS) involvement has not been formerly re-evaluated. We report here the outcome of patients with initial CNS involvement included in the pediatric-inspired prospective randomized GRAALL-2005 study. Between 2006 and 2014, 784 adult patients (aged 18-59 years) with newly diagnosed Philadelphia-negative ALL were included, of whom 55 (7%) had CNS involvement.

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Effectiveness and safety of risankizumab induction therapy for 100 patients with Crohn's disease: A GETAID multicentre cohort study.

Aliment Pharmacol Ther

February 2023

Department of Gastroenterology and Inserm NGERE U1256, Nancy University Hospital, University of Lorraine, Vandoeuvre-lès-Nancy, France.

Background: Phase III trials have demonstrated the efficacy of risankizumab in moderate-to-severe Crohn's disease (CD), but no real-world data are currently available. We aimed to assess the short-term effectiveness and safety of risankizumab in patients with CD.

Methods: From May 2021 to May 2022, all patients with refractory luminal CD treated with risankizumab in 22 French GETAID centres were retrospectively included.

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Introduction: Transplantation from controlled donation after circulatory determination of death (cDCD) is a new practice in France. An additional specific consent is required for registration on the cDCD waiting list. The aim of this study is to evaluate the impact of cDCD acceptance on the waiting time for the registered patients on the transplant list.

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Article Synopsis
  • The study explores the effectiveness and safety of off-label targeted therapies in patients with rare autoimmune and inflammatory diseases.
  • A total of 100 patients were enrolled, primarily middle-aged women, with a variety of targeted therapies being used and a significant proportion still on corticosteroid treatments.
  • Results indicated that 56% of patients found the treatment effective, leading to a significant reduction in corticosteroid dosage, while the overall tolerance of these therapies was deemed acceptable despite some serious health incidents.
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Landmark artery identification in the neurovascular bundle (NVB) is important for nerve-sparing in radical prostatectomy. We aimed to investigate intraoperative angiography using indocyanine green and near-infrared fluorescence (ICG-NIRF) during robot-assisted radical prostatectomy (RARP) to identify the NVB, visualise vascularisation and haemostasis, and preserve erectile function. Our retrospective, unicentric study was performed in consecutive localised prostate cancer RARP patients (stage T1/T2, prostate-specific antigen < 10 ng/ml) who underwent ICG-NIRF angiography in France (2016-2021).

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Unmet supportive care needs of caregivers according to medical settings of cancer patients: a cross-sectional study.

Support Care Cancer

November 2022

CNRS, UMR 9193, SCALab, Sciences Cognitives et Sciences Affectives, Université de Lille, Rue du Barreau, BP 60149, 59653, Lille, Villeneuve d'Ascq cedex, France.

Purpose: The objectives of this study were to compare the unmet supportive care needs (SCN) of caregivers and describe the 10 most frequent of them according to various cancer settings: phase of cancer care pathway (i.e., treatment vs.

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