Early clindamycin for bacterial vaginosis in pregnancy (PREMEVA): a multicentre, double-blind, randomised controlled trial.

Background: Preterm delivery during pregnancy (<37 weeks' gestation) is a leading cause of perinatal mortality and morbidity. Treating bacterial vaginosis during pregnancy can reduce poor outcomes, such as preterm birth. We aimed to investigate whether treatment of bacterial vaginosis decreases late miscarriages or spontaneous very preterm birth.

Axillary Transcatheter Aortic Valve Replacement in Patients With Peripheral Vascular Disease.

The axillary artery seems an interesting alternative in nonfemoral transaortic valve replacement (TAVR) patients. This study describes our experience with this technique and its short-term follow-up results. This is a retrospective single center study.

Perseverative Thinking Questionnaire (PTQ): French Validation of a Transdiagnostic Measure of Repetitive Negative Thinking.

Repetitive negative thinking (RNT) is a transdiagnostic process involved in the onset and maintenance of many psychological disorders. The Perseverative Thinking Questionnaire (Ehring et al., 2011) is a content-independent scale composed of 15 items that assesses RNT from a transdiagnostic perspective in both clinical and general populations.

Acute hyperventilation increases the central venous-to-arterial PCO difference in stable septic shock patients.

Background: To evaluate the effects of acute hyperventilation on the central venous-to-arterial carbon dioxide tension difference (∆PCO) in hemodynamically stable septic shock patients.

Methods: Eighteen mechanically ventilated septic shock patients were prospectively included in the study. We measured cardiac index (CI), ∆PCO, oxygen consumption (VO), central venous oxygen saturation (ScvO), and blood gas parameters, before and 30 min after an increase in alveolar ventilation (increased respiratory rate by 10 breaths/min).

[Low flux dialysate daily home hemodialysis: A result for the 62 first French and Belgian patients].

Since 2011, a new device is available for low flux dialysate quotidian home hemodialysis in France and Belgium. This study aims to evaluate the characteristics and dialysis prescriptions for Nx Stage System One™ users. We retrospectively included patients trained between 2011 and 2013 in France and Belgium.

[Mitochondrial Neuro-Gastro-Intestinal Encephalopathy (MNGIE): When and how to suspect it in front of an atypical anorexia nervosa?].

Introduction: The Mitochondrial Neurogastrointestinal Encephalopathy (MNGIE) disease is an extremely underrated syndrome beginning around the age of eighteen years. Because of its severity, this diagnosis should be considered when a patient presents an atypical anorexia nervosa. MNGIE disease is inherited in an autosomal recessive manner and related to mutations of the TYMP gene (ch22q13.

New hyperekplexia mutations provide insight into glycine receptor assembly, trafficking, and activation mechanisms.

Hyperekplexia is a syndrome of readily provoked startle responses, alongside episodic and generalized hypertonia, that presents within the first month of life. Inhibitory glycine receptors are pentameric ligand-gated ion channels with a definitive and clinically well stratified linkage to hyperekplexia. Most hyperekplexia cases are caused by mutations in the α1 subunit of the human glycine receptor (hGlyR) gene (GLRA1).

[Is the bacterial vaginosis risk factor of prematurity? Study of a cohort of 1336 patients in the hospital of Arras].

Background: Among risk factors of prematurity, bacterial vaginosis (BV) could play an important role, but few studies took place in our country.

Aim: In a French population of women booking in a hospital maternity, to search a link between prematurity and BV in the first trimester of pregnancy.

Methods: A hospital cohort study was carried out between May 2006 and September 1(st), 2009.

Risk of biliary complications in bariatric surgery.

Gallstones are commonly observed after rapid weight loss, particularly after bariatric surgery. Preventive measures of gallstone formation and potential related complications are still debated. This study aimed to propose a standardized strategy according to the results of the literature.

[Breast cancer and pregnancy].

Unlabelled: As maternal age at the time of pregnancy continues to increase and the incidence of breast cancer is raising, the incidence of pregnancy associated with breast cancer can be expected to increase. A review of the literature was performed to help identify optimal treatment strategies.

Methods: a search of electronic databases between 1967 and the present identifies studies reporting breast cancer associated with pregnancy.

[Acute myocardial infarction: what is new?].

Current recommendations on the management of acute myocardial infarction and the use of thrombolysis are reviewed.

[What are the consequences of smoking on pregnancy and delivery].

According to a WHO report of 1997, more than one-third of the world population of more than 15 years old smokes. Since the 90s, smoking progressed amongst women and teenagers. The noxious roles of smoking addiction to smoking on male and female fertility, pregnancy and delivery are often little known or underestimated by the public and most healthcare professionals.

[Neonatal management of a child exposed to tobacco smoke in utero].

The gravidic toxicity of the nicotinism on the fetus is now established. Certain long-term effects related to some substances, including certain unquestionable carcinogens, still remain to be evaluated. The risk of preterm birth is increased and the incidence of the intra-uterine growth retardation is high.

[How should markers of smoking be used during pregnancy?].

Consultation or hospitalization for pregnancy, irrespective of the patient's motivation, is always an exceptional opportunity for coupling care for the smoking addiction with antenatal surveillance. In studies on markers of smoking addiction during pregnancy, the most used markers are expired carbon monoxide (CO) and urinary cotinine. Expired CO can be used to estimate the level of active or passive smoking and thus enable the mother to realize the risks for her baby and appreciate how easy it is to decrease these risks.

Expired air carbon monoxide concentration in mothers and their spouses above 5 ppm is associated with decreased fetal growth.

Background: Smoking during pregnancy is associated with reduced birthweight; this relation can be reversed by smoking cessation. Some but not all previous studies have shown that smoking reduction (measured as cigarettes/day or urinary cotinine) may also improve birthweight. The relationship between maternal and spouses' expired air carbon monoxide (CO) concentrations (EACO) on fetal growth has not yet been evaluated.

[Surgical treatment of carpometacarpal joint osteoarthritis of the thumb by trapeziectomy-interposition-ligamentoplasty].

Introduction: Osteoarthritis of the carpometacarpal joint of the thumb is a common pathology. Several surgical methods exist, including trapeziectomy, arthrodesis, cemented or cementless prosthesis. Therefore, one must question the legitimacy of non prosthetic surgery.