82 results match your criteria: "centre hospitalier d'Annecy[Affiliation]"

Background: Hypereosinophilic syndromes (HES) are a heterogenous group of eosinophilic disorders. To date, only retrospective studies of limited sample-size and/or follow-up duration are available.

Methods: The COHESion study is a national prospective multicenter multidisciplinary cohort recruiting both adults or children with the spectrum of eosinophilic disorders (including reactive HE/HES [HE/HES-R], idiopathic HES [HES-I], lymphocytic HES [HES-L], neoplastic HE/HES [HE/HES-N], HE of unknown significance [HE-US], as well as IgG4-related disease [IgG4RD] or ANCA-negative eosinophilic granulomatosis with polyangiitis [EGPA] overlaps).

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Article Synopsis
  • PCSK9 is crucial for regulating LDL-cholesterol and certain variants, like p.Ser127Arg, lead to higher cholesterol levels and are mainly found in France, with few in South Africa and Norway due to a common ancestor effect.
  • The study analyzed 14 p.Ser127Arg carriers from eight families and compared them with other variants to understand their genetic background and health impact.
  • Results indicated that the common ancestor lived about 775 years ago, and carriers of p.Ser127Arg had significantly higher LDL-C levels, suggesting it may have a stronger effect on cholesterol levels compared to other mutations.
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Condylar process fractures remain a matter of ongoing controversy in maxillofacial surgery because of variety of opinions and proposed treatment modalities offered in the literature. The trend is toward open reduction and internal fixation (ORIF) whenever there is displacement or dislocation combined with unstable occlusal conditions. The fundamental treatment goals are anatomical fixation and early return to function.

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Efficacy and safety of an early oral switch in low-risk Staphylococcus aureus bloodstream infection (SABATO): an international, open-label, parallel-group, randomised, controlled, non-inferiority trial.

Lancet Infect Dis

May 2024

Institute for Medical Microbiology, Immunology and Hygiene, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany; German Centre for Infection Research, Partner Site Bonn-Cologne, Cologne, Germany; Institute of Translational Research, CECAD Cluster of Excellence, University of Cologne, Cologne, Germany.

Article Synopsis
  • This study investigates the effectiveness and safety of switching from intravenous to oral antibiotics after 5-7 days in patients with low-risk Staphylococcus aureus bloodstream infections.
  • Conducted across 31 hospitals in Europe, the trial aimed to determine if early oral therapy could maintain patient safety and reduce complications compared to ongoing intravenous treatment.
  • Due to slow participant recruitment, the trial was halted early with 215 participants, and the analysis was adjusted to ensure statistical validity, focusing on whether oral treatment led to acceptable complication rates compared with the traditional intravenous approach.
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ANCA-associated scleritis: impact of ANCA on presentation, response to therapy and outcome.

Rheumatology (Oxford)

February 2024

Department of Internal Medicine, Hôpital Cochin, AP-HP, Paris, France.

Objectives: To describe the characteristics, treatment and outcome of isolated ANCA-associated scleritis at diagnosis compared with idiopathic scleritis with negative ANCA tests.

Methods: This retrospective multicentre case-control study was performed within the French Vasculitis Study Group (FVSG) network and in three French tertiary ophthalmologic centres. Data from patients with scleritis without any systemic manifestation and with positive ANCA results were compared with those of a control group of patients with idiopathic scleritis with negative ANCA tests.

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  • The study evaluated the effectiveness of telephone hotlines for infectious disease (ID) support as part of antimicrobial stewardship programs aimed at controlling antibiotic resistance.
  • Data was collected from 10 ID teams across different French regions, documenting over 4,000 requests for advice from general practitioners (GPs) from April 2019 to June 2022, showing significant regional variations in hotline usage.
  • The main reasons for GPs reaching out included diagnostic inquiries and antibiotic choices, indicating that these hotlines can enhance collaboration between primary care and specialized medical settings, although sustainable institutional and financial backing is necessary for their continued operation.
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Background: European guidelines order management of patients with ST-segment elevation myocardial infarction (STEMI) less than 12 hours. They encourage healthcare networks to rapid coronary reperfusion strategy depending on the distance of the patient from the PCI center.

Objective: To determine impact of out-of-hospital presentation of patients with STEMI in remote areas within the framework of a care network, and to define the degree of compliance with local recommendations, and its prognostic impact.

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A new 165-SNP low-density lipoprotein cholesterol polygenic risk score based on next generation sequencing outperforms previously published scores in routine diagnostics of familial hypercholesterolemia.

Transl Res

May 2023

Service de Biochimie et de Biologie Moléculaire, Laboratoire de Biologie Médicale MultiSites, Hospices Civils de Lyon, Bron, France; Laboratoire CarMen, INSERM U1060, INRAE U1397, Oullins, France. Electronic address:

Genetic diagnosis of familial hypercholesterolemia (FH) remains unexplained in 30 to 70% of patients after exclusion of monogenic disease. There is now a growing evidence that a polygenic burden significantly modulates LDL-cholesterol (LDL-c) concentrations. Several LDL-c polygenic risk scores (PRS) have been set up.

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Objectives: To describe the characteristics, treatment and outcome of patients with immune thrombocytopenia with clinical significance (ITPCS) associated with SLE.

Methods: This retrospective multicentre study included SLE patients who experienced ≥1 ITPCS (defined as ITP with attributable bleeding disorders and/or a platelet count <30×109/l). Other causes of secondary thrombocytopenia were excluded.

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Topographic superficial craniectomy for invasive scalp carcinoma.

Int J Oral Maxillofac Surg

August 2022

Service de Chirurgie Maxillo-Faciale, Centre Hospitalier d'Annecy Genevois, Annecy, France.

The management of non-melanoma skin cancer of the scalp that invades the deep structures can be challenging. An operative technique of topographic superficial craniectomy using a piezoelectric instrument (Piezosurgery (Mectron S.p.

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Aims: Periprocedural myocardial infarctions have been reported in the setting of planned percutaneous coronary intervention (PCI). We assessed the prevalence of nonculprit artery acute myocardial infarction (NCAMI) and its relationship with coronary artery characteristics, final infarct size, and 1-year adverse clinical outcomes in a population of anterior ST-elevated myocardial infarction (STEMI) patients.

Methods And Results: Late gadolinium-enhanced cardiac magnetic resonance (LGE-CMR) studies were performed within 7 days of admission in 129 anterior STEMI patients from the CIRCUS trial treated by primary PCI.

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Article Synopsis
  • Thrombocytopenia in MDS and CMML:
  • Despite being moderate in prevalence for low-risk myelodysplastic syndromes (MDS) and chronic myelomonocytic leukaemia (CMML), thrombocytopenia poses significant risks for severe bleeding, and current treatment options remain limited.
  • Efficacy of Eltrombopag (ELT):
  • In a retrospective study involving 61 patients (50 with MDS and 11 with CMML), ELT demonstrated a platelet response in 77% of patients, with a median duration of response lasting about 8 months, and none of the patients who stopped treatment relapsed within a follow-up period.
  • Safety and Comp
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Article Synopsis
  • Prolonged Covid-19 poses significant challenges for patients with lymphoma or immune deficiencies, as shown in a study of 111 adults hospitalized in France during March-April 2020.
  • The research found that factors like age over 70, having relapsed/refractory lymphoma, and recent treatment with anti-CD20 therapy are linked to longer hospital stays and higher mortality rates.
  • The study highlights the need for tailored management and vaccination strategies for lymphoma patients during the pandemic, given that the 6-month overall survival rate following hospitalization was only 69%.
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Replantation of a lip thrown in the bin.

J Stomatol Oral Maxillofac Surg

February 2022

Service de Chirurgie Maxillo-Faciale, Centre Hospitalier d'Annecy Genevois, Annecy France; Faculté de Médecine, Université Grenoble Alpes, Grenoble France. Electronic address:

Management of soft tissue avulsion after facial bites could be challenging in some situation. We presented the case of a 32 years old men suffering from a full thickness avulsion of the left lower lip and cheek after a dog bite. Even if the lip fragment was initially put on the bin, a microvascular replantation was performed.

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Noninvasive Monitoring of Deep Tissue Oxygenation in Buried Flaps by Time-Resolved Near-Infrared Spectroscopy in Pigs.

Plast Reconstr Surg

November 2020

From the Service de Chirurgie Maxillo-faciale, Centre Hospitalier d'Annecy Genevois; INSERM-UGA U1209, CNRS UMR5309, Institute for Advanced Biosciences; and Université Grenoble Alpes, CEA, LETI, DTBS, LS2P.

Background: Flap monitoring in reconstructive surgery is particularly important because flap failure is a dramatic event for the patient and for the medical team. Noninvasive deep tissue oxygenation monitoring is a challenge. The aim of this experimental study was to assess the performance of time-resolved near-infrared spectroscopy compared with continuous-wave near-infrared spectroscopy and with invasive oxygen partial pressure measurement in pigs.

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Background: In recent years, many devices have been developed to monitor free flaps. The Licox probe, which measures tissue oxygen pressure (PtO ), is one of the available devices. Our aim was to demonstrate that PtO could distinguish arterial from venous occlusion in a porcine fascio-cutaneous flap model.

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Takotsubo cardiomyopathy. Takotsubo cardiomyopathy, or transient apical ballooning syndrome of the left ventricle, affects women after menopause often after mental or physical stress. Mimicking clinical, electrocardiographic and biological features of an acute coronary syndrome, it requires admission to the intensive care unit and an immediate coronary angiography, which will show the absence of coronary occlusion or rupture of atheromatous plaque.

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Importance: Approximately one-third of patients considered for coronary revascularization have diabetes, which is a major determinant of clinical outcomes, often influencing the choice of the revascularization strategy. The usefulness of fractional flow reserve (FFR) to guide treatment in this population is understudied and has been questioned.

Objective: To evaluate the usefulness and rate of major adverse cardiovascular events (MACE) of integrating FFR in management decisions for patients with diabetes who undergo coronary angiography.

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The ability of remote ischemic preconditioning (RIPC) to prevent contrast-induced nephropathy (CIN) following percutaneous coronary angiography in at-risk patients is controversial. No evidence exists regarding potential RIPC positive effects on renal function and clinical outcomes in the long-term. The PREPARE study was a randomized, prospective, multicenter, and double-blinded trial.

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Introduction And Aim: Data on the efficacy and tolerance of interferon-free treatment in chronic hepatitis C (CHC) in elderly patients are limited in phase II-III trials.

Material And Methods: A prospective cohort of adult patients with CHC treated in French general hospitals.

Results: Data from 1,123 patients, distributed into four age groups, were analyzed.

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Hepatitis C treatment with all-oral direct-acting antivirals: Effectiveness and tolerance in a multicenter, prospective, observational study from French general hospitals (APROVVIE, ANGH).

Presse Med

March 2019

Service d'hépatogastroentérologie, centre hospitalier de Pau, 528, route de la Coustète, Calotis, 40240 Mauvezin d' Armagnac, France; Service d'hépatogastroentérologie, centre hospitalier d'Avignon, 84000 Avignon, France; Service d'hépatogastroentérologie, centre hospitalier de Perpignan, Perpignan, 66000 France; Service d'hépatogastroentérologie, centre hospitalier intercommunal de Créteil, 94100 Créteil, France; Service d'hépatogastroentérologie, centre hospitalier régional d'Orléans, 45000 Orléans, France; Service d'hépatogastroentérologie, centre hospitalier d'Annecy, 74000 Annecy, France; Service d'hépatogastroentérologie. centre hospitalier du grand Est parisien, 77600 Jossigny, France; Service d'hépatogastroentérologie, centre hospitalier d'Haine-Saint-Paul, 7100 Haine-Saint-Paul, Belgium; Service d'hépatogastroentérologie, centre hospitalier d'Hyères, 83400 Hyères, France; Service d'hépatogastroentérologie, centre hospitalier de La-Roche-sur-Yon, 85000 La-Roche-sur-Yon, France; Service d'hépatogastroentérologie, centre hospitalier de Meaux, Meaux, 77100 France; Service d'hépatogastroentérologie, centre hospitalier d'Aix-en-Provence, 13100 Aix-en-Provence, France; Service d'hépatogastroentérologie, centre hospitalier du Mans, 72000 Le Mans, France; Service d'hépatogastroentérologie, centre hospitalier de Montélimar, 26200 Montélimar, France; Service d'hépatogastroentérologie, centre hospitalier de Creil, 60100 Creil, France; Service d'hépatogastroentérologie, centre hospitalier de Chambéry, 73000 Chambéry, France; Service d'hépatogastroentérologie, centre hospitalier de Montfermeil, 93370 Montfermeil, France; Service d'hépatogastroentérologie, centre hospitalier de Gonesse, 95500 Gonesse, France; Service d'hépatogastroentérologie, centre hospitalier de Béziers, 34500 Béziers, France; Service d'hépatogastroentérologie, centre hospitalier de Cholet, 49280 Cholet, France; Service d'hépatogastroentérologie, centre hospitalier de Bry-sur-Marne, 94360 Bry-sur-Marne, France; Service d'hépatogastroentérologie, centre hospitalier d'Aubagne, 13400 Aubagne, France; Service d'hépatogastroentérologie, centre hospitalier de Saint-Denis, 93200 Saint-Denis, France; Service d'hépatogastroentérologie, centre hospitalier de Beaune, 21200 Beaune, France.

Background And Aims: According to clinical trials, the treatment of patients with chronic hepatitis C (CHC) with second-generation direct acting antiviral agents (DAAs) is highly efficient and well tolerated. The goal of this study was to investigate the effectiveness and safety of various combinations of these drugs during their first 2 years of use in the real-world practice of French general hospitals.

Methods: Data from patients treated with all-oral DAAs in 24 French non-academic hospital centers from March 1, 2014 to January 1, 2016, were prospectively recorded.

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Introduction: In Europe, the number of cases of Campylobacter enteritis and their quinolone resistance is increasing. The aims of this work were to evaluate: (1) the hospital epidemiology of bacterial enteritis between 2010 and 2015. (2) The proportion of Campylobacter and Salmonella enteritis.

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Sexual life is an important dimension of quality of life, which may be affected by the fear of transmission in people living with HIV/AIDS (PLWHA), despite the fact that antiretroviral therapy prevents person-to-person transmission. We, therefore, aimed to explore the sexual life satisfaction of PLWHA and its correlation with their fear of HIV transmission and self-esteem. Consecutive adult PLWHA from seven HIV care facilities in the Rhone-Alpes region, France, were asked to complete a self-administered, anonymous questionnaire concerning sociological and medical data, satisfaction with sexual life (18 questions), and self-esteem (Rosenberg score).

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