498 results match your criteria: "centre Val-de-Loire[Affiliation]"

Modeling and Characterization of Multilayer Piezoelectric Stacks via Dynamic Stiffness Method.

Micromachines (Basel)

December 2024

GREMAN UMR 7347 CNRS, Université de Tours, INSA Centre Val de Loire, 3 Rue de la Chocolaterie, 41000 Blois, France.

Multilayer piezoelectric stacks, which are multiple layers of piezoelectric materials placed on top of each other, are widely used to achieve precise linear movement and high-force generation. In this paper, a dynamic stiffness (DS) method for the dynamic vibration analysis of multilayer piezoelectric stacks is presented. First, the general solutions for all physical quantities of the three vibration contributions (i.

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Background: Mirror therapy shows promise in the treatment of phantom limb pain but lacks robust evidence.

Objectives: To address this gap, we conducted a scoping review aiming to comprehensively explore the landscape of mirror therapy practice, gather details about the session content, and offer recommendations for future research.

Method: We searched seven databases for published work from 1995 to May 2023.

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Trends in the epidemiology of intravascular device-associated bacteremia among French hematology patients: insights from the SPIADI prospective multicenter study, 2020-2024.

Ann Hematol

January 2025

Mission Nationale Surveillance et Prévention des Infections Associées aux Dispositifs Invasifs (SPIADI), Centre d'Appui pour la Prévention des Infections Associées aux Soins en région Centre val de Loire, Centre Hospitalier Régional Universitaire, Hôpital Bretonneau, Tours, France.

Hematology patients require central venous catheters for cancer treatment and nutrition, which increases their risk of intravascular device-associated bacteremia. In the absence of recent data, we investigated intravascular device-associated bacteremia in this specific context. A three-month surveillance was conducted annually in 27 hematology wards, using a protocol derived from the HAI-Net ICU ECDC protocol (2020-2024).

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Rationale: Early detection, standardized therapy, adequate infrastructure and strategies for quality improvement should constitute essential components of every hospital's sepsis plan.

Objectives: To investigate the extent to which recommendations from the sepsis guidelines are implemented and the availability of infrastructure for the care of patients with sepsis in acute hospitals.

Methods: A multidisciplinary cross-sectional questionnaire was used to investigate sepsis care in hospitals.

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The current study investigates and compares the biological effects of ultrathin conformal coatings of zirconium dioxide (ZrO) and vanadium pentoxide (VO) on osteoblastic MG-63 cells grown on TiO nanotube layers (TNTs). Coatings were achieved by the atomic layer deposition (ALD) technique. TNTs with average tube diameters of 15, 30, and 100 nm were fabricated on Ti substrates (via electrochemical anodization) and were used as primary substrates for the study.

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This study develops a dynamics model of a microrobot vibrating in a blood vessel aiming to detect potential cancer metastasis. We derive an analytical solution for microrobot's motion, considering interactions with the vessel walls modelled by a linear spring-dashpot and a constant damping value for blood viscosity. The model facilitates instantaneous state transitions of the microrobot, such as contact with the vessel wall and free motion within the fluid.

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Unraveling neural adaptation to vocal and non-vocal sounds in autism.

Clin Neurophysiol

December 2024

Université de Tours, INSERM, Imaging Brain and Neuropsychiatry iBraiN U1253, 37032, Tours, France; EXAC·T, Centre Universitaire de Pédopsychiatrie, CHRU de Tours, Tours, France. Electronic address:

Objective: Autism is linked to a strong need for sameness and difficulties in social communication, associated with atypical brain responses to voices and changes. This study aimed to characterize neural adaptation in autistic adults using a Roving paradigm and assess how vocal vs. non-vocal, as well as neutral vs.

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Background And Aims: Systemic sclerosis (SSc) is an autoimmune connective disease characterised by excessive extracellular matrix deposition and widespread skin and internal organ fibrosis including various cardiac manifestations. Heart involvement is one of the leading causes of death among patients with SSc. In this study, we aimed to assess the effect of various vasodilator treatments.

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We investigate a method for fabricating layers that exhibit both high optical absorption and promising thermoelectric properties. Using plasma-enhanced chemical vapor deposition (PECVD), amorphous Si and SiGe layers are deposited on glass substrates and subsequently processed via laser annealing to achieve nanostructured layers. Our results show that a single laser annealing pulse at 40 mJ yields the highest power factor, approximately 90 μW/m·K.

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Introduction: This study evaluates the performance of ChatGPT, particularly its versions 4 and 4o, in answering questions from the French orthopedic and trauma surgery exam (Diplôme d'Études Spécialisées, DES), compared to the results of French orthopedic surgery residents. Previous research has examined ChatGPT's capabilities across various medical specialties and exams, with mixed results, especially in the interpretation of complex radiological images.

Hypothesis: ChatGPT version 4o was capable of achieving a score equal to or higher (not lower) than that of residents for the DES exam.

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The enhanced national pharmacovigilance system implemented for COVID-19 vaccines in France: A 2-year experience report.

Therapie

November 2024

French National Agency for Medicines and Health Products Safety, ANSM, Direction for Surveillance, 93200 Saint-Denis, France.

In March 2020, World Health Organization recognized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emergence as a public health emergency of international concern. One of the major preventative measures developed against coronavirus disease 2019 (COVID-19) was vaccines. To monitor their use and safety of vaccines from the first utilization in humans during clinical development phases to implementation for the general population, an enhanced national pharmacovigilance system was enabled by the French National Agency for Medicines and Health Products Safety in collaboration with the 30 Regional Pharmacovigilance Centres.

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Objectives: The first COVID-19 lockdown raised concerns about reduced access to primary care, especially for people with chronic diseases particularly at risk in the absence of follow-up. However, the COVIQuest trial, evaluating the impact of a general practitioner (GP) phone call (intervention) to chronic patients with cardiovascular disease (CVD) or mental health disorder (MHD) concluded that the intervention had no effect at 1 month on the rate of self-reported hospitalisations in the CVD subtrial, whereas the intervention group in MHD subtrial might have a higher rate. This second part of the study aimed to describe the 6 month hospitalisation and specialised consultation rates, using the French health data system ().

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Today, dairy cattle farmers are seeking to optimize expenditure and productivity throughout the lives of their animals by focusing on efficiency at all levels. One strategy for bringing forward the start of a dairy cow's profitability phase is to advance the onset of puberty and reduce the animal's age at their first calving. Thus, one objective of this study was to feed two groups of Holstein dairy heifers the same diet but in different quantities, with the aim of generating a growth differential of at least 200 g/day between the two groups.

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Topotactic Reduction-Induced Stabilization of β-LaMoO Phase: Structure, Static Oxygen Disorder, and Electrical Properties.

Inorg Chem

December 2024

MOE Key Laboratory of New Processing Technology for Nonferrous Metals and Materials, Guangxi Universities Key Laboratory of Non-ferrous Metal Oxide Electronic Functional Materials and Devices, College of Materials Science and Engineering, Guilin University of Technology, Guilin 541004, PR China.

LaMoO is acknowledged as an exceptional oxide ion conductor. It undergoes a reversible phase transition around 580 °C from the nonconductive low-temperature monoclinic α-LaMoO phase to the highly conductive high-temperature cubic β-LaMoO phase. In addition, LaMoO demonstrates complex chemistry under reducing conditions.

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Diffuse lung diseases ascribed to drugs: a nationwide observational study over 37 years using the French pharmacovigilance database.

Eur Respir J

November 2024

Service de Pneumologie et Soins Intensifs Respiratoires, Centre de Référence Constitutif des Maladies Pulmonaires Rares de l'Adultes de Dijon, réseau OrphaLung, Filière RespiFil, Centre Hospitalier Universitaire Dijon-Bourgogne, Dijon, France

Background: Drug-induced interstitial lung disease (DI-ILD) is a heterogeneous subgroup of interstitial lung diseases (ILD). The number of molecules involved is increasing with time. Due to their low incidence, DI-ILDs may be detected only after a drug has been marketed, notably through Adverse Drug Reaction (ADR) reports to pharmacovigilance centres.

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Incidence and mortality of prostate cancer in France from 2010 to 2021, using a real-life database (National Health Data System - SNDS) - the CaPCo Study.

World J Urol

October 2024

Epidemiology Unit for Clinical Data in Centre-Val de Loire (EpiDcliC), Teaching Hospital of Tours, Faculty of Medicine, University of Tours, Infectiology Committee of the French Urology Association (CIAFU), Tours, France.

Background And Objective: Prostate cancer (PCa) was the leading incident cancer and 3rd leading cause of cancer death in men in France in 2015 with inter-regional disparities. The objectives were to describe PCa incidence and mortality in France and by region, using real life data from the National Health Data System and to identify the factors associated with all-cause or PCa-specific mortality.

Methods: Men aged ≥ 18years hospitalized and/or on long-term care for PCa (ICD-10 code C61) in France between 2010 and 2021 were included.

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Introduction: First-line oxygenation strategy in patients with acute hypoxaemic respiratory failure consists in standard oxygen or high-flow nasal oxygen therapy. Clinical practice guidelines suggest the use of high-flow nasal oxygen rather than standard oxygen. However, findings remain contradictory with a low level of certainty.

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Article Synopsis
  • The study aimed to track the outcomes of patients with brain arteriovenous malformations (AVMs) who were managed conservatively, revealing key statistics on related morbidity and mortality over a 10-year period.
  • Out of 1010 patients initially recruited, 434 were analyzed, with a majority having unruptured low-grade AVMs, demonstrating a 5% occurrence of serious outcomes and a higher risk in those with a history of rupture or older age.
  • During the follow-up of approximately 3.2 years, 8% of patients experienced major intracranial hemorrhages, highlighting the ongoing risks associated with conservative management of AVMs.
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Article Synopsis
  • The study compared outcomes of mechanical thrombectomy (MT) in children with acute ischemic stroke (AIS) caused by focal cerebral arteriopathy (FCA) and cardioembolism (CE).
  • Data was merged from two cohorts, analyzing factors like revascularization success and functional outcomes using standardized assessment tools.
  • Results showed CE patients had better revascularization rates and potential functional outcomes compared to those with FCA, stressing the need for more research on treating pediatric strokes, especially related to FCA.
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Impact of sterile gloving during proximal manipulation of central line catheter hub: the multicenter observational study CleanHandPROX.

Antimicrob Resist Infect Control

October 2024

Centre d'appui Pour La Prévention Des Infections Associées Aux Soins, en Région Centre-Val de Loire, Hôpital Bretonneau, Centre Hospitalier Régional Universitaire, 37044, Tours, France.

Article Synopsis
  • - The study aimed to examine the use of sterile gloves by healthcare workers (HCWs) during manipulations of central line catheters, which can carry a risk of infections like bacteremia.
  • - Observations revealed that 72% of HCWs used sterile gloves, while 19% did not wear any gloves at all, with microbial contamination found on the fingertips of 28% of those tested.
  • - The findings indicated that fingertip contamination was lower among HCWs who wore sterile gloves, highlighting the importance of glove use in preventing infections during central line handling.
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Cavitation dose monitoring plays a key role in ultrasound drug delivery to the brain. The use of capacitive micromachined ultrasonic transducer (CMUT) technology has a great potential for passive cavitation detection (PCD).Here, a circular (diameter 7 mm) CMUT centered at 5 MHz was designed to be inserted into a therapeutic transducer (1.

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Classification of germline non-truncating variants: a new approach to interpretation.

J Med Genet

November 2024

Cancer Genetics Unit, Institut Bergonié, Bordeaux, Aquitaine, France.

Article Synopsis
  • PTEN hamartoma tumour syndrome (PHTS) includes syndromes like Cowden syndrome, with missense variants making up 30% of PHTS cases, yet their classification is complex.
  • A study from the Bergonie Institute identified 76 non-truncating variants in 166 patients, developing a new classification method using criteria like functional analysis, phenotypic features, and familial patterns.
  • The new approach successfully reclassifies 25 variants, revealing the need to update current classification standards based on multiple factors, and it requires further validation in future research.
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The long-term tolerability of linezolid is low because of mitochondrial toxicity, whereas tedizolid may represent a better option for suppressive therapy. We report a first presumed case of tedizolid-associated optic neuropathy after a very prolonged (18-month) intake and believe that screening for optic neuropathy should be considered for patients undergoing tedizolid suppression.

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Deep learning applied to raw data has demonstrated outstanding image classification performance, mainly when abundant data is available. However, performance significantly degrades when a substantial volume of data is unavailable. Furthermore, deep architectures struggle to achieve satisfactory performance levels when distinguishing between distinct classes, such as fine-grained image classification, is challenging.

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Article Synopsis
  • The study investigates the prevalence of depressive symptoms in patients who survived spontaneous intracerebral hemorrhage (ICH) and their correlation with cognitive decline and dementia risk.
  • Using hierarchical clustering analysis, researchers identified three distinct profiles of depressive symptoms among the 221 patients screened: no significant symptoms, symptoms with predominant apathy, and symptoms with predominant anxiety.
  • Patients with depressive symptoms and predominant apathy exhibited higher chances of brain atrophy and an increased risk of developing dementia compared to those with no depressive symptoms, emphasizing the importance of tailored screening for better management.
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