1 results match your criteria: "c 3 Sungkyunkwan University[Affiliation]"

TBK1 inhibitors: a review of patent literature (2011 - 2014).

Expert Opin Ther Pat

July 2016

c 3 Sungkyunkwan University, Department of Genetic Engineering , 300 Chuncheon-Dong, Suwon 440-746, Korea +82 312 907 868 ; +82 312 907 870 ;

Introduction: TANK-binding kinase 1 (TBK1) is a noncanonical IκB kinase family member that regulates the innate immune response. Misregulation of TBK1 activity can promote inflammatory disorders and oncogenesis; therefore, TBK1 inhibitors are considered a promising therapy for inflammation and cancer.

Areas Covered: In this review, the authors provide information on the role of TBK1 in human health and on recently developed inhibitors from patents granted from 2011 to 2014.

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