Recent advances with cyclin-dependent kinase inhibitors: therapeutic agents for breast cancer and their role in immuno-oncology.

: Collaborative interactions between several diverse biological processes govern the onset and progression of breast cancer. These processes include alterations in cellular metabolism, anti-tumor immune responses, DNA damage repair, proliferation, anti-apoptotic signals, autophagy, epithelial-mesenchymal transition, components of the non-coding genome or onco-mIRs, cancer stem cells and cellular invasiveness. The last two decades have revealed that each of these processes are also directly regulated by a component of the cell cycle apparatus, cyclin D1.

Destigmatization by Association: Improving Children's Reactions to an Obese Storybook Character.

Second- through fourth-grade students were read a storybook that described a typical boy who interacted with an obese boy for one of four reasons (sympathy, curiosity, teacher instructed, or no reason) to explore the manner in which a typical storybook character's reason for associating with an obese storybook character influences children's responses to both characters. Results revealed that the children responded more favorably to the obese storybook character after than before learning about the typical storybook character's association with him, especially when the typical storybook character's reason for association was presented as internally motivated (sympathy or curiosity). In contrast to "stigma by association" findings reported in prior research, the children also responded more favorably to the typical storybook character after than before his association with the obese storybook character.

Individual Differences Associated with Emotional and Behavioral Responses to Ambiguous Social Situations in which Rejection Might be Inferred.

This study sought to examine the extent to which undergraduates' experiences with and attitudes relevant to rejection may be associated with their emotional and behavioral responses to ambiguous social situations in which rejection might be inferred. Undergraduate students completed questionnaires that assessed their experiences with and attitudes relevant to being rejected. Next, each participant read six hypothetical scenarios that described various situations that could be interpreted as interpersonal rejection.