Factors associated with delayed and late ART initiation among people living with HIV in BC: results from the engage study.

We examined correlates of late and delayed initiation of antiretroviral therapy (ART) in British Columbia, Canada. From December 2013 to December 2015 we recruited treatment-naïve people living with HIV who initiated ART within the previous year. 'Late initiation' was defined as CD4 cell count ≤500 cells/µL at ART initiation and 'delayed initiation' as ≥1 year between HIV diagnosis and initiation.

The Influence of Epoch Length on Physical Activity Patterns Varies by Child's Activity Level.

Purpose: Patterns of physical activity (PA) and sedentary time, including volume of bouted activity, are important health indicators. However, the effect of accelerometer epoch length on measurement of these patterns and associations with health outcomes in children remain unknown.

Method: We measured activity patterns in 308 children (52% girls, age range = 8-11 years) using ActiGraph GT1M accelerometers with 15-s epochs and reintegrated to 60-s epochs.

Stigma and Developmental Disabilities in Nursing Practice and Education.

Individuals with developmental disabilities (DD) experience stigma, discrimination, and barriers, including access to appropriate health care, that restrict their ability to be equal participants in society. In this study, underlying contexts, assumptions, and ways of acting are investigated that perpetuate inequalities and pejorative treatment toward those with disabilities. Several nurse researchers and educators suggest specific content for, or approaches to, education about DD.

Sustainable childhood obesity prevention through community engagement (SCOPE) program: evaluation of the implementation phase.

Childhood obesity rates are steadily rising. Sustainable Childhood Obesity Prevention Through Community Engagement (SCOPE) is a community-based participatory action research (PAR) program aimed at preventing childhood obesity. This study aimed to describe community perspectives on, and elicit feedback about, SCOPE's first phase of implementation in two pilot cities in British Columbia, Canada.

Adjusting Incremental Fit Indices for Nonnormality.

A variety of indices are commonly used to assess model fit in structural equation modeling. However, fit indices obtained from the normal theory maximum likelihood fit function are affected by the presence of nonnormality in the data. We present a nonnormality correction for 2 commonly used incremental fit indices, the comparative fit index and the Tucker-Lewis index.

On Johnson's (2000) Relative Weights Method for Assessing Variable Importance: A Reanalysis.

This article provides a reanalysis of J. W. Johnson's (2000) "relative weights" method for assessing variable importance in multiple regression.

Role of PPARγ in adipocyte recruitment and thermogenesis.

PPARγ is an important transcription factor in the process of adipocyte recruitment and differentiation. Its relevance in vivo has been clearly observed using genetically modified animal models with different degrees of PPARγ function impairment. These animals showed defects in white and brown adipose tissue development and plasticity.

Endocrine and inflammatory alterations in post-traumatic stress disorder.

Post-traumatic stress disorder has frequently been found associated with alterations in endogenous stress hormone systems, for example the hypothalamus-pituitary-adrenal axis and sympatho-adrenal-medullary system. Hormonal alterations are observed at the central and peripheral level of the central nervous system, and in the periphery for inflammatory disinhibition. Both consequences bear significant hazards for the individual, the former by sustaining or exacerbating the psychiatric condition, the latter by its detrimental effects on somatic health.