Uric acid transporters hiding in the intestine.

Context: Hyperuricaemia is known as an abnormally increased uric acid level in the blood. Although it was observed many years ago, since uric acid excretion via the intestine pathway accounted for approximately one-third of total elimination of uric acid, the molecular mechanism of 'extra-renal excretion' was poorly understood until the finding of uric acid transporters.

Objective: The objective of this study was to gather all information related to uric acid transporters in the intestine and present this information as a comprehensive and systematic review article.