435 results match your criteria: "at Brigham and Women's Hospital[Affiliation]"

Roadblocks to Cancer Care in the Occupied Palestinian Territories.

Health Hum Rights

December 2024

Founding director of the Science Health Education Center at Dana-Farber Cancer Institute and a senior scientist at Dana-Farber's Department of Cancer Immunology and Virology, with appointments in the Departments of Microbiology and Global Health and Social Medicine at Harvard Medical School, Boston, United States.

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Article Synopsis
  • An epidemiological cohort analysis was conducted using data from the Surveillance Epidemiology and End Results national cancer database (2002-2012) to examine the impact of PM (particulate matter < 2.5 microns) on head and neck cancer (HNC) incidence.
  • The study found a significant link between PM exposure and HNC, particularly noting the strongest association at a 5-year lag (β=0.24, p<0.001), with additional significant associations noted for no lag and up to a 20-year lag.
  • Further subgroup analysis is recommended to deepen the understanding of how PM exposure contributes to HNC development.
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Ambient beta particle radioactivity and lung cancer survival: Results from the Boston Lung Cancer Study.

Environ Res

January 2025

Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:

Background: Exposure to ionizing radiation is known to increase the risk of lung cancer. However, studies on the effect of environmental radiation associated with ambient particle air pollution on lung cancer survival are limited. We investigated the association between ambient beta particle radioactivity (PR-β) after a diagnosis and lung cancer survivals.

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Objective: We sought to correlate the time lag between psoriatic arthritis (PsA) symptom onset and diagnosis to the likelihood and severity of depression, social impairment, and disease impact on quality of life.

Methods: This cross-sectional study conducted by the National Psoriasis Foundation (NPF) surveyed individuals with PsA using patient-reported outcome measures.

Results: The analysis cohort comprised 2,196 patients with PsA.

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Machine-Learning-Based Multi-Modal Force Estimation for Steerable Ablation Catheters.

IEEE Trans Med Robot Bionics

August 2024

Department of Electrical and Computer Engineering, Western University, London, ON, Canada, and Canadian Surgical Technologies and Advanced Robotics (CSTAR), University Hospital, LHSC, London, ON, Canada.

Catheter-based cardiac ablation is a minimally invasive procedure for treating atrial fibrillation (AF). Electrophysiologists perform the procedure under image guidance during which the contact force between the heart tissue and the catheter tip determines the quality of lesions created. This paper describes a novel multi-modal contact force estimator based on Convolutional Neural Networks (CNNs) and Recurrent Neural Networks (RNNs).

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Navigating the Labyrinth of Pregnancy-Related Coverage for Undocumented Immigrants: An Assessment of Current State and Federal Policies.

Am J Public Health

October 2024

Amanda DiMeo is with Ariadne Labs at Brigham and Women's Hospital and Harvard T. H. Chan School of Public Health, Boston, MA. Rasheca Logendran is with Harvard Medical School, Boston. Benjamin D. Sommers is with Harvard Medical School and Harvard T. H. Chan School of Public Health. Alexandra Beecroft and Yessamin Pazos Herencia are with Brigham Young University, Provo, UT. Maria Bazan, Jeffrey Sprankle, and Rose L. Molina are with the Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston. Carrie Wade is with Countway Library, Harvard Medical School. Margaret M. Sullivan is with François-Xavier Bagnoud Center for Health and Human Rights, Harvard University, Boston.

Insurance coverage for prenatal care, labor and delivery care, and postpartum care for undocumented immigrants consists of a patchwork of state and federal policies, which varies widely by state. According to federal law, states must provide coverage for labor and delivery through Emergency Medicaid. Various states have additional prenatal and postpartum coverage for undocumented immigrants through policy mechanisms such as the Children's Health Insurance Program's "unborn child" option, expansion of Medicaid, and independent state-level mechanisms.

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LAG-3 sustains TOX expression and regulates the CD94/NKG2-Qa-1b axis to govern exhausted CD8 T cell NK receptor expression and cytotoxicity.

Cell

August 2024

Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, USA; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Parker Institute for Cancer Immunotherapy, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

Article Synopsis
  • Exhausted CD8 T cells in chronic viral infections and cancer express inhibitory receptors (IRs) like PD-1, which can be blocked to reinvigorate T cell function.
  • Co-targeting multiple IRs, such as PD-1 and LAG-3, can enhance T cell response and disease control beyond blocking PD-1 alone.
  • The study reveals distinct functions of PD-1 and LAG-3 in T cell activity, showing LAG-3's role in T cell durability and in creating a subset of T cells that are more effective at killing cancer or infected cells.
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Leader self-care: Using visual arts sessions to enhance leader well-being and teamwork.

Nurs Manage

August 2024

At Brigham and Women's Hospital in Boston, Mass., Brooke DiGiovanni Evans is the co-founder and director of the Visual Arts in Healthcare Program, and Pamela Brown Linzer is the associate CNO, Patient Care Services and the Center for Nursing Excellence.

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Vaping habits and respiratory symptoms using a smartphone app platform.

BMC Public Health

July 2024

Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard T.H. Chan School of Public Health, 665 Huntington Ave, Building I Room 1406A, Boston, MA, 02115, USA.

Background: Widespread use of e-cigarette (EC) or vaping products causes respiratory disorders including the nationwide outbreak of e-cigarette or vaping product use-associated lung injury (EVALI) in 2019. Chronic adverse health effects are now being reported as well. To address this important public health issue, an innovative approach of epidemic control and epidemiologic study is required.

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Background And Objectives: Geographic accessibility predicts pediatric preventive care utilization, including vaccine uptake. However, spatial inequities in the pediatric coronavirus disease 2019 (COVID-19) vaccination rollout remain underexplored. We assessed the spatial accessibility of vaccination sites and analyzed predictors of vaccine uptake.

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Mounting evidence indicates that blueberry consumption is associated with a variety of health benefits. It has been suggested that regular consumption of blueberries can support and/or protect against cardiovascular disease and function, pre-diabetes and type 2 diabetes, and brain and cognitive function in individuals with health conditions and age-related decline. Further, mechanistic investigations highlight the role of blueberry anthocyanins in mediating these health benefits, in part through interactions with gut microbiota.

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Background And Objectives: Patients who speak languages other than English face barriers to equitable healthcare delivery. Machine translation systems, including emerging large language models, have the potential to expand access to translation services, but their merits and limitations in clinical practice remain poorly defined. We aimed to assess the performance of Google Translate and ChatGPT for multilingual translation of pediatric discharge instructions.

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There has been little attention given to roles played by human trafficking in health care organizations' supply chains. Hand sanitizers and gloves, for example, might be produced by forced labor, which tends to increase in prevalence during pandemics, mass violence, migration, or other global crises. This article considers the nature and scope of health care organizations' corporate and social responsibilities to procure products and personnel justly, offers recommendations to minimize possibilities that supplies are produced by forced labor, and advocates for a public health approach to limiting human trafficking in organizations' supply chains.

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Background: Undocumented immigrants face many barriers in accessing pregnancy care, including language differences, implicit and explicit bias, limited or no insurance coverage, and fear about accessing services. With the national spotlight on maternal health inequities, the current literature on undocumented immigrants during pregnancy requires synthesis.

Objective: We aimed to describe the literature on pregnancy care utilization, experiences, and outcomes of undocumented individuals in the United States.

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Objective: To assess the association between breastfeeding competency, as determined by Latch, Audible swallowing, Type of nipple, Comfort, and Hold (LATCH) and Preterm Infant Breastfeeding Behavior Scale (PIBBS) scores, and exclusive breastfeeding and growth among infants with low birth weight (LBW) in India, Malawi, and Tanzania.

Study Design: We conducted LATCH and PIBBS assessments among mother-infant dyads enrolled in the Low Birthweight Infant Feeding Exploration (LIFE) observational study of infants with moderately LBW (1500g-2499 g) in India, Malawi, and Tanzania. We analyzed feeding and growth patterns among this cohort.

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Health Care Access and Use Among U.S. Children Exposed to Neighborhood Violence.

Am J Prev Med

June 2024

Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia; PolicyLab, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

Introduction: Neighborhood violence is an adverse childhood experience which impacts millions of U.S. children and is associated with poor health outcomes across the life course.

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An Integrative Review of the State of POLST Science: What Do We Know and Where Do We Go?

J Am Med Dir Assoc

April 2024

School of Nursing, Indiana University, Indianapolis, IN, USA; Research in Palliative and End-of-Life Communication and Training (RESPECT) Signature Center, Indiana University Purdue University Indianapolis, Indianapolis, IN, USA; Indiana University Center for Aging Research, Regenstrief Institute, Inc, Indianapolis, IN, USA.

Objectives: POLST is widely used in the care of seriously ill patients to document decisions made during advance care planning (ACP) conversations as actionable medical orders. We conducted an integrative review of existing research to better understand associations between POLST use and key ACP outcomes as well as to identify directions for future research.

Design: Integrative review.

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