141 results match your criteria: "and the University of Washington School of Medicine[Affiliation]"
Semin Hematol
January 2012
Gastroenterology/Hepatology Section, Fred Hutchinson Cancer Research Center and the University of Washington School of Medicine, Seattle, WA 98109-1024, USA.
Gastrointestinal and hepatobiliary problems in the second year after allogeneic hematopoietic cell transplant (HCT) are usually a continuation of symptoms of protracted acute graft-versus-host disease (GVHD), chronic GVHD, medication side effects, and infection related to immune suppression. As time passes, as tolerance develops, and as immunity improves, the frequency and severity of these problems wane, but new problems involving the gut and liver may arise, sometimes insidiously and sometimes decades after the transplant. Examples are esophageal strictures related to chronic GVHD, gallstones, cirrhosis caused by chronic hepatitis C, secondary malignancy, and rare cases of pancreatic atrophy.
View Article and Find Full Text PDFJ Vasc Surg
October 2011
Division of Vascular Surgery, VA Puget Sound Health Care System and the University of Washington School of Medicine, Seattle, Wash., USA.
Objective: Infrainguinal autogenous vein grafts are especially prone to narrowing and failure, and both inflammatory and thrombotic pathways are implicated. Platelets and monocytes are the key thrombo-inflammatory cells that arrive first at sites of vascular injury. These cells have potent interactions that recruit and activate one another, propagating thrombotic and inflammatory responses within the vessel wall.
View Article and Find Full Text PDFCan J Anaesth
July 2011
Department of Anesthesiology and Pain Medicine, Seattle Children's Hospital and the University of Washington School of Medicine, 4800 Sand Point Way NE, Seattle, WA, 98105, USA.
Purpose: To report the anesthetic management of a successful resection of a pheochromocytoma in a child with a completed Fontan circulation.
Clinical Features: The patient was an 11-yr-old boy with Ivemark syndrome who had undergone Fontan palliation at three years of age. Six weeks earlier, he had been diagnosed with a norepinephrine-producing pheochromocytoma, and he had been pretreated with oral propranolol and phenoxybenzamine.
Expert Rev Hematol
June 2010
Fred Hutchinson Cancer Research Center and the University of Washington School of Medicine, Seattle, WA, USA.
Allogeneic hematopoietic cell transplantation (HCT) is a potentially curative procedure for a variety of hematologic malignancies. The field has evolved substantially over the past decade, with advances in patient and donor selection, stem cell sources, supportive care, prevention of complications and reduced-toxicity preparative regimens. As a result, the indications for HCT and the pool of eligible patients have expanded significantly.
View Article and Find Full Text PDFTransfusion
October 2010
Puget Sound Blood Center and the University of Washington School of Medicine, Seattle, Washington 98104-1256, USA.
Background: Using bacterial detection or pathogen reduction, extended platelet (PLT) storage may be licensed if PLT viability is maintained. The Food and Drug Administration (FDA)'s poststorage PLT acceptance guidelines are that autologous stored PLT recoveries and survivals should be 66 and 58% or greater, respectively, of each donor's fresh PLT data.
Study Design And Methods: Nonleukoreduced PLT concentrates were prepared from whole blood donations.
Bone Marrow Transplant
May 2010
Fred Hutchinson Cancer Research Center and the University of Washington School of Medicine, Seattle, WA 98109, USA.
The transplantation of hematopoietic stem cells from unrelated volunteer donors and cord blood units is made possible through an international collaboration of registries and cord blood banks. The World Marrow Donor Association (WMDA) is a non-profit association based in Leiden, the Netherlands, whose mission is to assure that high-quality stem cell products are available for all patients in need, while maintaining the health and safety of the volunteer donors. This goal is accomplished through the work of six working groups and six board committees, in which issues of global significance to the clinical hematopoietic cell transplantation community are identified and guidelines are established.
View Article and Find Full Text PDFBiol Blood Marrow Transplant
October 2009
Fred Hutchinson Cancer Research Center and the University of Washington School of Medicine, Seattle, Washington 98109-1024, USA.
We summarized results in 38 consecutive patients (median age=56 years) with hematologic malignancies (n=35), aplastic anemia (n=2), or renal cell carcinoma (n=1), who underwent salvage hematopoietic cell transplantation (HCT) for allograft rejection. In 14 patients, the original donors were used for salvage HCT, and, in 24 cases, different donors were used. Conditioning for salvage HCT consisted of fludarabine (Flu) and either 3 or 4 Gy total body irradiation (TBI).
View Article and Find Full Text PDFNat Clin Pract Urol
February 2009
Fred Hutchinson Cancer Research Center and the University of Washington School of Medicine, Seattle, WA 98195, USA.
Androgen deprivation therapy remains a critical component of treatment for men with advanced prostate cancer, and data support its use in metastatic disease and in conjunction with surgery or radiation in specific settings. Alternatives to standard androgen deprivation therapy, such as intermittent androgen suppression and estrogen therapy, hold the potential to improve toxicity profiles while maintaining clinical benefit. Current androgen deprivation strategies seem to incompletely suppress androgen levels and androgen-receptor-mediated effects at the tissue level.
View Article and Find Full Text PDFBiol Blood Marrow Transplant
January 2009
The Fred Hutchinson Cancer Research Center and the University of Washington School of Medicine, Seattle, Washington, USA.
N Engl J Med
October 2008
Department of Medicine, Veterans Affairs Puget Sound Health Care System and the University of Washington School of Medicine, Seattle, USA.
Infect Control Hosp Epidemiol
September 2008
Primary and Specialty Medicine Service, Veterans Affairs Puget Sound Health Care System and the University of Washington School of Medicine, Seattle, Washington, USA.
Clin Immunol
May 2008
Benaroya Research Institute and the University of Washington School of Medicine, 1201 9th Avenue, Seattle, WA 98101, USA.
The immune phenotype of the partial remission phase or "honeymoon phase" of type 1 diabetes is not well defined. We compared flow cytometry and cytokine production by ELISPOT assays in children with newly diagnosed type 1 diabetes and children in the partial remission phase of type 1 diabetes. Newly diagnosed children had higher levels of FoxP3 expression in CD4 CD25 double positive cells (56.
View Article and Find Full Text PDFPaediatr Anaesth
February 2008
Department of Anesthesiology and Pain Medicine, Children's Hospital and Regional Medical Center and the University of Washington School of Medicine, Seattle, WA 98105, USA.
The loss-of-resistance technique was used to place a 20G epidural needle in the lumbar region in an anesthetized and paralyzed infant. There was no cerebrospinal fluid (CSF) leakage and a 24G catheter was inserted through the needle. At end of surgery, when the patient was breathing spontaneously and a bupivacaine bolus was given through the catheter, a total spinal block was identified.
View Article and Find Full Text PDFJ Cardiothorac Vasc Anesth
December 2007
Department of Anesthesiology and Pain Medicine, Children's Hospital and Regional Medical Center and the University of Washington School of Medicine, Seattle, WA 98105, USA.
Exp Hematol
November 2007
Fred Hutchinson Cancer Research Center and the University of Washington School of Medicine, Seattle, WA 98109-1024, USA.
Myelodysplastic syndrome (MDS), previously known as preleukemia, comprises a spectrum of heterogeneous, clonal disorders of hematopoiesis. A patient's life expectancy can range from a few months to more than a decade. Recent studies provide some insight into the pathophysiology of MDS.
View Article and Find Full Text PDFPLoS Med
July 2007
Fred Hutchinson Cancer Research Center and the University of Washington School of Medicine, Seattle, Washington, United States of America.
Stanley Riddell and Frederick Appelbaum review progress in preventing graft-versus-host disease following allogeneic hematopoietic cell transplantation for malignancies or other life-threatening blood diseases.
View Article and Find Full Text PDFJ Hosp Med
May 2007
Primary and Specialty Medicine Service, Veterans Affairs Puget Sound Health Care System, Department of Medicine, and the University of Washington School of Medicine, Seattle, Washington 98108, USA.
Biol Blood Marrow Transplant
March 2007
Fred Hutchinson Cancer Research Center and the University of Washington School of Medicine, Seattle, Washington 98109-1024, USA.
A total of 104 patients, aged 18 to 70 years, with a diagnosis of chronic idiopathic myelofibrosis (CIMF), polycythemia vera (PV), or essential thrombocythemia (ET) with marrow fibrosis were transplanted from allogeneic (56 related and 45 unrelated) or syngeneic (n = 3) donors. Busulfan (BU) or total body irradiation (TBI)-based myeloablative conditioning regimens were used in 95 patients, and a nonmyeloablative regimen of fludarabine plus TBI was used in 9 patients. The source of stem cells was bone marrow in 43 patients and peripheral blood in 61 patients.
View Article and Find Full Text PDFBiol Blood Marrow Transplant
January 2007
Fred Hutchinson Cancer Research Center and the University of Washington School of Medicine, Seattle, Washington, USA.
Allogeneic HCT after myeloablative conditioning is an effective therapy for patients with hematologic malignancies. In an attempt to extend this therapy to older patients or those with comorbidities, reduced intensity or truly nonmyeloablative regimens have been developed over the past decade. The principle underlying reduced intensity regimens is to provide some tumor kill with lessened regimen-related morbidity and mortality and then rely on graft-versus-tumor (GVT) effects to eradicate remaining malignant cells, whereas nonmyeloablative regimens rely primarily on GVT effects.
View Article and Find Full Text PDFHematology Am Soc Hematol Educ Program
June 2007
Fred Hutchinson Cancer Research Center and the University of Washington School of Medicine, Seattle, WA 98109, USA.
Reduced-intensity conditioning (RIC) regimens were initially introduced to provide allogeneic stem cell transplantation (HCT), a potentially curative procedure for myeloid malignancies, for patients who were not considered eligible for conventional myeloablative HCT either because of advanced age or excessive comorbidities. A variety of RIC regimens have been studied. The exact definition of RIC remains arbitrary and generally depends upon the perceived toxicity of a given regimen rather than the actual dose of chemotherapy or radiotherapy administered.
View Article and Find Full Text PDFCirc Res
October 2006
Department of Surgery, Division of Vascular Surgery, Veterans Affairs Puget Sound Health Care System and the University of Washington School of Medicine, Seattle, USA.
We describe extracellular interactions between fibronectin (Fn) and vascular endothelial growth factor (VEGF) that influence integrin-growth factor receptor crosstalk and cellular responses. In previous work, we found that VEGF bound specifically to fibronectin (Fn) but not vitronectin or collagens. Herein we report that VEGF binds to the heparin-II domain of Fn and that the cell-binding and VEGF-binding domains of Fn, when physically linked, are necessary and sufficient to promote VEGF-induced endothelial cell proliferation, migration, and Erk activation.
View Article and Find Full Text PDFMedicine (Baltimore)
July 2006
From United States Immune Deficiency Network (JAW, MCM, CCR, HDO), the Immune Deficiency Foundation (JAW, MCM), the Johns Hopkins University School of Medicine (JAW, HML), the University of Arkansas for Medical Sciences (SMJ, AWB), the University of Pennsylvania School of Medicine (KS), the University of Tennessee School of Medicine (MEC), the Mt Sinai School of Medicine (CCR), and the University of Washington School of Medicine (HDO).
X-linked agammaglobulinemia (XLA) is a primary immunodeficiency caused by mutations in the gene for Bruton tyrosine kinase (BTK) that result in the deficient development of B lymphocytes and hypogammaglobulinemia. Because the disorder is uncommon, no single institution has had sufficient numbers of patients to develop a comprehensive clinical picture of the disorder. Accordingly, a national registry of United States residents with XLA was established in 1999 to provide an updated clinical view of the disorder in a large cohort of patients.
View Article and Find Full Text PDFRadiographics
September 2006
Children's Hospital and Regional Medical Center and the University of Washington School of Medicine, 4800 Sand Point Way NE, Seattle, WA 98105, USA.
The interpretation of magnetic resonance (MR) images of the pediatric brain may require consultation of an atlas to determine if a perceived finding represents an abnormality. However, most hard-copy atlases show only a few levels of the brain at selected points of time in myelination, and therefore a simultaneous comparison of different age groups is difficult with a hard-copy approach. The authors believe that a digital atlas of the normal pediatric brain may be a more efficient way to present this information and that correct interpretation of potential abnormalities may be facilitated by the online atlas they have created (available for free download from http://radiology.
View Article and Find Full Text PDFBlood
July 2006
Clinical Research Division, Fred Hutchinson Cancer Research Center and the University of Washington School of Medicine, Seattle, 98109, USA.
Algorithms for grading acute graft-versus-host disease (GVHD) are inaccurate in assessing mortality risk. We developed a method to predict mortality by using data from 386 patients with acute GVHD. From the onset of GVHD to day 100, GVHD manifestations were scored for the skin, liver, and upper and lower gastrointestinal tract, and data were recorded for immunosuppressive treatment, performance, and fever.
View Article and Find Full Text PDFBiol Blood Marrow Transplant
February 2006
Medical Oncology, Clinical Research Division, Fred Hutchinson Cancer Research Center and the University of Washington School of Medicine, Seattle, Washington 98109, USA.
Graft-versus-host disease (GVHD) is seen in skin, intestinal mucosa, and liver after autologous stem cell transplantation. We reviewed 681 consecutive patients to estimate the probability of gastrointestinal (GI) GVHD, response to treatment, risk factors for development, and effect on survival. GI GVHD was defined by persistent symptoms, mucosal abnormalities at endoscopy, and histology showing apoptotic crypt cells with or without lymphoid infiltrates.
View Article and Find Full Text PDF