187 results match your criteria: "and the University of Minnesota[Affiliation]"
As-Needed Blood Pressure Medication and Adverse Outcomes in VA Hospitals.
JAMA Intern Med
January 2025
Division of General Internal Medicine, Department of Medicine, School of Medicine, and Center for Pharmaceutical Policy and Prescribing, Health Policy Institute, University of Pittsburgh, Pittsburgh, Pennsylvania.
Importance: Asymptomatic blood pressure (BP) elevations in the hospital are commonly treated with as-needed BP medications, including recurring as-needed and 1-time administration. Veterans represent a population at risk of ischemic events from rapid lowering of BP, but the impact of as-needed BP medication use in this population is unknown.
Objective: To assess the risks of acute kidney injury (AKI) and other outcomes from as-needed BP medication administration in a hospitalized veteran cohort.
An Agenda for Addressing Health-Harming Legal Needs in Indigenous Communities.
Am J Public Health
November 2024
Michele Statz is with the Department of Family Medicine and Biobehavioral Health, University of Minnesota Medical School, Duluth, and the University of Minnesota Law School, Minneapolis. Brieanna Watters is with the Department of Sociology, University of Minnesota, Minneapolis.
Treatment of Stages I-III Squamous Cell Anal Cancer: A Comparative Effectiveness Systematic Review.
J Natl Cancer Inst
August 2024
Division of Colon & Rectal Surgery, Department of Surgery, University of Minnesota, Minneapolis, MN, USA.
Purpose: To assess the effectiveness and harms of initial treatment strategies for stages I-III anal squamous cell cancer (SCC).
Methods: We searched Medline®, Embase®, and CENTRAL®, between January 1, 2000- March 2024, for randomized controlled trials and nonrandomized studies of interventions comparing initial treatment strategies. Individual study risk of bias (RoB) and overall strength of evidence (SOE) were evaluated for a prespecified outcome list using standardized methods.
Nonpharmacologic and Pharmacologic Treatments of Adults in the Acute Phase of Major Depressive Disorder: A Living Clinical Guideline From the American College of Physicians (Version 1, Update Alert 2).
Ann Intern Med
August 2024
Minneapolis VA Health Care System and the University of Minnesota Schools of Medicine and Public Health, Minneapolis, Minnesota.
ST Elevation is a poor surrogate for acute coronary occlusion. Let's Replace STEMI with Occlusion MI (OMI)!!
Int J Cardiol
July 2024
Hennepin Healthcare, ER R-2, 701 S. Park Ave, Minneapolis, MN 55419, United States.
Effect of BMI-Discordant Abdominal Tissue Thickness on Fracture Probability: A Registry-Based Study.
J Bone Miner Res
December 2023
Centre for Metabolic Bone Diseases, University of Sheffield Medical School, Sheffield, UK.
FRAX, which is used to assess fracture probability, considers body mass index (BMI), but BMI may not reflect individual variation in body composition and distribution. We examined the effect of BMI-discordant abdominal thickness on FRAX-derived fracture probability for major osteoporotic fracture (MOF) and hip fracture. We studied 73,105 individuals, mean age 64.
View Article and Find Full Text PDFTransplantation Outcomes with Donor Hearts after Circulatory Death.
N Engl J Med
June 2023
From Duke University Medical Center, Durham, NC (J.N.S., C.B.P., A.D.D., S.C., C.A.M.); Northwestern University (B.S.B., D.T.P.) and the University of Chicago (C.T.S.) - both in Chicago; Vanderbilt University Medical Center, Nashville (A.S., T.A.); University of Wisconsin Hospital and Clinics, Madison (J.W.S.), and the Medical College of Wisconsin, Milwaukee (D.L.J.); the University of California, San Francisco, San Francisco (A.G.F.), the University of California, San Diego, La Jolla (V.P.), Cedars-Sinai Medical Center, Los Angeles (F.E.), and Stanford University Medical Center, Stanford (Y.S.) - all in California; Emory University Hospital, Atlanta (M.D., T.S.A.); Advent Health, Orlando (S.S.), Mayo Clinic, Jacksonville (S.M.P.), and Tampa General Hospital, Tampa (J.D., L.L.) - all in Florida; Yale School of Medicine, New Haven, CT (A.G.); Nebraska Medical Center, Omaha (J.Y.U.); Columbia University Medical Center, New York (K.T.), Montefiore Medical Center, Bronx (D.J.G.), and Westchester Medical Center, Valhalla (M.K.) - all in New York; Minneapolis Heart Institute Foundation (K.M., B.S., B.C.S.) and the University of Minnesota Medical Center (A.W.S.) - both in Minneapolis; Sentara Norfolk General Hospital, Norfolk (J.P.), and Virginia Commonwealth University, Richmond (M.A.Q.) - both in Virginia; Tufts Medical Center (G.S.C.), Brigham and Women's Hospital (H.R.M., M.M.G., M.R.M.), and Massachusetts General Hospital (J.C.M., D.A.D.) - all in Boston; and the University of Texas Southwestern Medical Center, Dallas (M.F.).
Background: Data showing the efficacy and safety of the transplantation of hearts obtained from donors after circulatory death as compared with hearts obtained from donors after brain death are limited.
Methods: We conducted a randomized, noninferiority trial in which adult candidates for heart transplantation were assigned in a 3:1 ratio to receive a heart after the circulatory death of the donor or a heart from a donor after brain death if that heart was available first (circulatory-death group) or to receive only a heart that had been preserved with the use of traditional cold storage after the brain death of the donor (brain-death group). The primary end point was the risk-adjusted survival at 6 months in the as-treated circulatory-death group as compared with the brain-death group.
New-Onset Left Bundle Branch Block With ST Elevation After Minimally Invasive Aortic Valve Replacement: Differential Diagnosis.
Ann Emerg Med
May 2023
Heart Center, Department of Cardiology, Tampere University Hospital and Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Purpose: We have previously developed and externally validated a prognostic model of overall survival (OS) in men with metastatic, castration-resistant prostate cancer (mCRPC) treated with docetaxel. We sought to externally validate this model in a broader group of men with docetaxel-naïve mCRPC and in specific subgroups (White, Black, Asian patients, different age groups, and specific treatments) and to classify patients into validated two and three prognostic risk groupings on the basis of the model.
Methods: Data from 8,083 docetaxel-naïve mCRPC men randomly assigned on seven phase III trials were used to validate the prognostic model of OS.
Background: Burnout has risen across healthcare workers during the pandemic, contributing to workforce turnover. While prior literature has largely focused on physicians and nurses, there is a need to better characterize and identify actionable predictors of burnout and work intentions across healthcare role types.
Objective: To characterize the association of work overload with rates of burnout and intent to leave (ITL) the job in a large national sample of healthcare workers.
The Pediatric Bougie for the First Tracheal Intubation Attempt in Critically Ill Children.
Ann Emerg Med
June 2023
Department of Emergency Medicine, Hennepin County Medical Center.
Study Objective: Bougie use during emergency tracheal intubation has not been well studied in children.
Methods: This was a 10-year observational study of pediatric intubations (<18 years of age) in the emergency department (ED) of an academic institution. Bougie training and use are standard in our ED, including for emergency medicine residents.
Antithrombotic therapy in patients with COVID-19: indications, pharmacotherapy and controversy.
Stroke Vasc Neurol
August 2023
Hennepin Healthcare System and the University of Minnesota, Minneapolis, Minnesota, USA.
Associations of COVID-19 Outcomes with Dialysis Modalities and Settings.
Clin J Am Soc Nephrol
October 2022
Chronic Disease Research Group, Hennepin Healthcare Research Institute, Minneapolis, Minnesota.
How maintenance dialysis modality, dialysis setting, and residence in a nursing facility have jointly associated with coronavirus disease 2019 (COVID-19)-related outcomes in the United States is relevant to future viral outbreaks. Using Medicare claims, we determined the incidence of COVID-19-related infection, hospitalization, and death between March 15, 2020 and June 5, 2021. The exposure was one of five combinations of dialysis modality and care setting: in-facility hemodialysis without a recent history of skilled nursing facility care, in-facility hemodialysis with a recent history of skilled nursing facility care, hemodialysis in a skilled nursing facility, home hemodialysis, and (home) peritoneal dialysis.
View Article and Find Full Text PDFVentilatory Parameters Measured After One Week of Mechanical Ventilation and Survival in COVID-19-Related ARDS.
Respir Care
January 2023
Division of Pulmonary and Critical Care Medicine, Hennepin County Medical Center, Minneapolis, Minnesota; and the University of Minnesota, Minneapolis, Minnesota.
Background: Ventilatory parameters measured soon after initiation of mechanical ventilation have limited ability to predict outcome of COVID-19-related ARDS. We hypothesized that ventilatory parameters measured after one week of mechanical ventilation might differ between survivors and non-survivors.
Methods: One hundred twenty-seven subjects with COVID-related ARDS had gas exchange and lung mechanics assessed on the day of intubation and one week later.
Periodontal and Other Oral Bacteria and Risk of Lung Cancer in the Atherosclerosis Risk in Communities (ARIC) Study.
Cancer Epidemiol Biomarkers Prev
April 2023
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
Background: Evidence suggests that periodontal disease is associated with increased lung cancer risk, but whether periodontal pathogens are explanatory is unknown. We prospectively studied associations of prediagnostic circulating antibodies with oral bacteria and of periodontal bacteria in subgingival plaque with lung cancer.
Methods: We included 4,263 cancer-free participants in the Atherosclerosis Risk in Communities study with previously measured serum IgG antibodies to 18 oral bacteria.
A First-in-Human Study of AMG 986, a Novel Apelin Receptor Agonist, in Healthy Subjects and Heart Failure Patients.
Cardiovasc Drugs Ther
August 2023
Orange County Research Center, 14351 Myford Rd, Suite B, Tustin, CA, 92780, USA.
Purpose: AMG 986 is a novel apelin receptor (APJ) agonist that improves cardiac contractility in animal models without adversely impacting hemodynamics. This phase 1b study evaluated the safety/tolerability, pharmacokinetics, and pharmacodynamics of AMG 986 in healthy subjects and patients with heart failure (HF).
Methods: Healthy adults (Parts A/B) and HF patients (Part C) aged 18-85 years were randomized 3:1 to single-dose oral/IV AMG 986 or placebo (Part A); multiple-dose oral/IV AMG 986 or placebo (Part B); or escalating-dose oral AMG 986 or placebo (Part C).
American Association of Oral and Maxillofacial Surgeons' Position Paper on Medication-Related Osteonecrosis of the Jaws-2022 Update.
J Oral Maxillofac Surg
May 2022
Chief of Staff North Memorial Health, Fellowship Director, Oral/Head and Neck Oncologic and Reconstructive Surgery Attending Surgeon, North Memorial Health and the University of Minnesota. Private practice, Minnesota Oral and Facial Surgery and Minnesota Head and Neck Surgery, Minneapolis, Minn.
Strategies for management of patients with, or at risk for, medication-related osteonecrosis of the jaws (MRONJ) - formerly referred to as bisphosphonate-related osteonecrosis of the jaws (BRONJ)-were set forth in the American Association of Oral and Maxillofacial Surgeons (AAOMS) position papers in 2007, 2009 and 2014. The position papers were developed by a committee appointed by the AAOMS Board of Trustees and comprising clinicians with extensive experience in caring for these patients, as well as clinical and basic science researchers. The knowledge base and experience in addressing MRONJ continues to evolve and expand, necessitating modifications and refinements to the previous position papers.
View Article and Find Full Text PDFBackground Guidelines promote shared decision-making (SDM) for anticoagulation in patients with atrial fibrillation. We recently showed that adding a within-encounter SDM tool to usual care (UC) increases patient involvement in decision-making and clinician satisfaction, without affecting encounter length. We aimed to estimate the extent to which use of an SDM tool changed adherence to the decided care plan and clinical safety end points.
View Article and Find Full Text PDFArrhythmic causes of in-hospital cardiac arrest among patients with heart failure with preserved ejection fraction.
Heart Rhythm O2
December 2021
Departments of Cardiology, Internal Medicine, and Research, Minneapolis VA Health Care System and the University of Minnesota, Minneapolis, Minnesota.
Inequitable Access to Hospital Care - Protecting Disadvantaged Populations during Public Health Emergencies.
N Engl J Med
December 2021
From the Program on Ethics and Decision Making in Critical Illness, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh (D.B.W.); Arizona Department of Health Services, Phoenix (L.V.); and Hennepin Healthcare and the University of Minnesota - both in Minneapolis (J.L.H.).
Diagnosis of Occlusion Myocardial Infarction in Patients with Left Bundle Branch Block and Paced Rhythms.
Curr Cardiol Rep
November 2021
Section of Cardiology, Department of Medicine, Baylor College of Medicine, MS: BCM620. One Baylor Plaza, Houston, TX, 77030, USA.
Purpose Of Review: A number of criteria have been developed to aid with the diagnosis of occlusion myocardial infarction (OMI) in patients with left bundle branch block (LBBB) and ventricular paced rhythms (VPR). The current guidelines do not provide clear preference for any specific ECG criteria in LBBB and paced rhythm patients.
Recent Findings: This review delineates the difficulties of electrocardiographic diagnosis of OMI in both LBBB and VPR patients.
Health screening needs independent regular re-evaluation.
BMJ
September 2021
Centre for Evidence-Based Medicine Odense (CEBMO) and Cochrane Denmark, Department of Clinical Research, University of Southern Denmark, Odense, Denmark.