10 results match your criteria: "and the Swiss Federal Institute of Technology[Affiliation]"

Article Synopsis
  • Alzheimer's disease (AD) is primarily a sporadic condition largely linked to the APOE ε4 gene, with limited disease-modifying treatments available, mainly aducanumab and lecanemab.
  • Attention-deficit hyperactivity disorder (ADHD) is common in children and persists into adulthood for many, with its treatment relying on first-line stimulants like methylphenidate (MPH) but lacking definitive disease-modifying therapies.
  • Research suggests potential links between ADHD and AD, including shared cognitive deficits and biological pathways, indicating that ADHD might increase the risk for developing AD and that treatments for ADHD might benefit cognitive function in early stages of dementia.
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In this paper, we present the detailed life-time dosimetry analysis for rodents exposed in the reverberation exposure system designed for the two-year cancer bioassay study conducted by the National Toxicology Program of the National Institute of Environmental Health Sciences. The study required the well-controlled and characterized exposure of individually housed, unrestrained mice at 1900 MHz and rats at 900 MHz, frequencies chosen to give best uniformity exposure of organs and tissues. The wbSAR, the peak spatial SAR and the organ specific SAR as well as the uncertainty and variation due to the exposure environment, differences in the growth rates, and animal posture were assessed.

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In this paper we present the novel design features, their technical implementation, and an evaluation of the radio Frequency (RF) exposure systems developed for the National Toxicology Program (NTP) of the National Institute of Environmental Health Sciences (NIEHS) studies on the potential toxicity and carcinogenicity of 2nd and 3rd generation mobile-phone signals. The system requirements for this 2-year NTP cancer bioassay study were the tightly-controlled lifetime exposure of rodents (1568 rats and 1512 mice) to three power levels plus sham simulating typical daily, and higher, exposures of users of GSM and CDMA (IS95) signals. Reverberation chambers and animal housing were designed to allow extended exposure time per day for free-roaming individually-housed animals.

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Theory-Based Computational Psychiatry.

Biol Psychiatry

September 2017

Department of Cognitive, Linguistic and Psychological Sciences, Department of Psychiatry and Human Behavior, and the Brown Institute for Brain Science, Brown University, Providence, Rhode Island.

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Neurocognition in help-seeking individuals at risk for psychosis: Prediction of outcome after 24 months.

Psychiatry Res

December 2016

The Zurich Program for Sustainable Development of Mental Health Services (ZInEP), University Hospital of Psychiatry Zurich, Switzerland; Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Psychiatry Zurich, Switzerland.

An important aim in schizophrenia research is to optimize the prediction of psychosis and to improve strategies for early intervention. The objectives of this study were to explore neurocognitive performance in individuals at risk for psychosis and to optimize predictions through a combination of neurocognitive and psychopathological variables. Information on clinical outcomes after 24 months was available from 118 subjects who had completed an extensive assessment at baseline.

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Erratum to: Stress, burnout, and job dissatisfaction in mental health workers.

Eur Arch Psychiatry Clin Neurosci

June 2016

Department of General and Social Psychiatry, Psychiatric University Hospital, University of Zurich, Militärstrasse 8, 8004, Zurich, Switzerland.

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Symptom dimensions are associated with reward processing in unmedicated persons at risk for psychosis.

Front Behav Neurosci

December 2014

Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Psychiatry Zurich, Switzerland ; Center for Integrative Human Physiology, University of Zurich Zurich, Switzerland.

There is growing evidence that reward processing is disturbed in schizophrenia. However, it is uncertain whether this dysfunction predates or is secondary to the onset of psychosis. Studying 21 unmedicated persons at risk for psychosis plus 24 healthy controls (HCs) we used a incentive delay paradigm with monetary rewards during functional magnetic resonance imaging.

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Objective: The literature proposes a joint structure of normal and pathological personality with higher-order factors mainly based on the five-factor model of personality (FFM). The purpose of the present study was to examine the joint structure of the FFM and the DSM-IV personality disorders (PDs) and to discuss this structure with regard to higher-order domains commonly reported in the literature.

Methods: We applied a canonical correlation analysis, a series of principal component analyses with oblique Promax rotation and a bi-factor analysis with Geomin rotation on 511 subjects of the general population of Zurich, Switzerland, using data from the ZInEP Epidemiology Survey.

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Wearable Digital Speech Processor for Cochlear Implants Using a TMS320C25.

Acta Otolaryngol

January 1990

Department of Otorhinolaryngology, University Hospital, Zürich and the Institute for Biomedical Engineering, Zürich University, and the Swiss Federal Institute of Technology, Zürich, Switzerland.

Based on a single-chip DSP (TMS320C25, Texas Instruments) a programmable battery-operated sound processor with a digital encoder interface for the Nucleus-22 cochlear implant (CI) was built. The number of quasi-simultaneously addressed electrodes is only limited by the selected pulse width and the maximum rate of stimulation and can be as high as 10 electrodes at 300 Hz repetition rate. Implementation of various processing strategies (formant or channel vocoder, filterbank, zero crossings, etc.

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