1 results match your criteria: "and the Massey Cancer Center Richmond[Affiliation]"
Is tail vein injection a relevant breast cancer lung metastasis model?
J Thorac Dis
August 2013
Division of Surgical Oncology, Department of Surgery, Virginia Commonwealth University School of Medicine, and the Massey Cancer Center Richmond, Virginia, USA.
Background: TWO MOST COMMONLY USED ANIMAL MODELS FOR STUDYING BREAST CANCER LUNG METASTASIS ARE: lung metastasis after orthotopic implantation of cells into the mammary gland, and lung implantations produced after tail vein (TV) injection of cells. Tail vein injection can produce lung lesions faster, but little has been studied regarding the differences between these tumors, thus, we examined their morphology and gene expression profiles.
Methods: Syngeneic murine mammary adenocarcinoma, 4T1-luc2 cells, were implanted either subcutaneously (Sq), orthotopically (OS), or injected via TV in Balb/c mice.