1 results match your criteria: "and the Johns Hopkins Asthma and Allergy Center[Affiliation]"
Inhibition of FcepsilonRI-dependent mediator release and calcium flux from human mast cells by sialic acid-binding immunoglobulin-like lectin 8 engagement.
J Allergy Clin Immunol
February 2008
Department of Medicine, Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, and the Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA.
Background: Sialic acid-binding immunoglobulin-like lectins (Siglecs) are a family of glycan-binding inhibitory receptors, and among them, Siglec-8 is selectively expressed on human eosinophils, basophils, and mast cells. On eosinophils, Siglec-8 engagement induces apoptosis, but its function on mast cells is unknown.
Objective: We sought to study the effect of Siglec-8 engagement on human mast cell survival and mediator release responses.