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Hepatology
March 2000
Section of Digestive Diseases, Yale University School of Medicine, and the Hepatic Hemodynamic Laboratory at the Veterans Administration Medical Center, West Haven, CT 06516, USA.
Peripheral vasodilation initiates the hyperdynamic circulation in cirrhosis. Somatostatin and its analogues, such as octreotide, have a vasoconstrictive effect in cirrhotic patients and experimental animals with portal hypertension. The exact mechanism of octreotide-induced vasoconstriction remains unknown.
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