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Effect of Graft Attachment Status and Intraocular Pressure on Descemet Stripping Automated Endothelial Keratoplasty Outcomes in the Cornea Preservation Time Study.

Am J Ophthalmol

July 2019

Case Western Reserve University Department of Ophthalmology and Visual Sciences, University Hospitals Eye Institute, and the Cornea Image Analysis Reading Center, Cleveland, Ohio, USA. Electronic address:

Purpose: To examine the association of donor, recipient, and operative factors on graft dislocation after Descemet stripping automated endothelial keratoplasty (DSAEK) in the Cornea Preservation Time Study (CPTS) as well as the effects of graft dislocation and elevated IOP on graft success and endothelial cell density (ECD) 3 years postoperatively.

Design: Cohort study within a multi-center, double-masked, randomized clinical trial.

Methods: 1090 individuals (1330 study eyes), median age 70 years, undergoing DSAEK for Fuchs endothelial corneal dystrophy (94% of eyes) or pseudophakic or aphakic corneal edema (6% of eyes).

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