29 results match your criteria: "and the Centers for Disease Control and Prevention[Affiliation]"
Multi-Level Approaches to Fetal Alcohol Spectrum Disorders Prevention Education and Training for Health Professionals.
Subst Use Addctn J
September 2024
Health Behavior Research and Training Institute, Steve Hicks School of Social Work, The University of Texas at Austin, Austin, TX, USA.
Background: Alcohol-exposed pregnancies, which can lead to fetal alcohol spectrum disorders (FASDs), is one of the most common preventable causes of lifelong intellectual and developmental disabilities in the U.S. Healthcare teams can play a critical role in preventing FASDs; however, they are currently unprepared to do so.
View Article and Find Full Text PDFHepatitis C Virus Testing During Pregnancy After Universal Screening Recommendations.
Obstet Gynecol
July 2022
Quest Diagnostics, Secaucus New Jersey; and the Centers for Disease Control and Prevention, Atlanta, Georgia.
The study evaluates the effect of the 2020 Centers for Disease Control and Prevention and U.S. Preventive Services Task Force recommendations on hepatitis C virus (HCV) screening among pregnant persons nationally and by health insurance type.
View Article and Find Full Text PDFAssociation between county-level sociodemographic characteristics and county-level differences in opioid dispensing.
Prev Med Rep
December 2021
Division of Overdose Prevention, National Center for Injury Prevention and Control, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Background: While overall opioid prescribing has been decreasing in the United States, the rates of prescribing at the county level have been variable. Previous studies show that social determinants of health (the social and economic conditions in which we live) may play a role in opioid prescribing; however, researchers have not examined this relationship across US counties. This cross-sectional study seeks to determine whether county-level sociodemographic characteristics (e.
View Article and Find Full Text PDFThe IARC Perspective on Cervical Cancer Screening.
N Engl J Med
November 2021
From the International Agency for Research on Cancer, Lyon (V.B., W.P., B.I.I.R., I.M.M., B.L.-S.), and the National Public Health Agency, Saint-Maurice (F.F.H.) - both in France; the National Cancer Institute, Rockville, MD (N.W., M. Schiffman); Public Health England and Screening, London (A.M.); Amsterdam University Medical Centers, Amsterdam (J. Berkhof); VCS Foundation, Melbourne, VIC (J. Brotherton), Australia; Azienda Unità Sanitaria Locale - IRCCS Reggio Emilia, Reggio Emilia, Italy (P.G.R.); the University of Toronto, Toronto (R.K.); the American Cancer Society (R. Smith), Emory University (M.H.C.), and the Centers for Disease Control and Prevention (M. Saraiya) - all in Atlanta; the Center for the Study of the State and Society, and the National Scientific and Technical Research Council - both in Buenos Aires (S.A.); the Casablanca Cancer Registry, Casablanca, Morocco (K.B.); The Daffodil Centre, a joint venture between the Cancer Council NSW and the University of Sydney, King's Cross, NSW, Australia (K.C.); the University of Zimbabwe College of Health Sciences, Harare (Z.M.C.); Hospital Clínic de Barcelona, Barcelona (M.P.); PATH, Seattle (S. de Sanjosé); Karolinska Institutet, Stockholm (M.E.); McGill University, Montreal (E.F.); Teikyo University, and the National Cancer Center - both in Tokyo (C.H.); the University of Edinburgh, Edinburgh (C.S.H.); Hospital Universitario San Ignacio, Bogota, Colombia (R.M.); the National Cancer Institute, Bangkok, Thailand (S. Sangrajrang); Research Triangle Institute International, New Delhi, India (R. Sankaranarayanan); Chinese Academy of Medical Sciences, Beijing (F.Z.); and Sciensano, Brussels (M.A.).
Substance Use among Men Who Have Sex with Men.
N Engl J Med
July 2021
From the National Institute on Drug Abuse, Bethesda, MD (W.M.C.); and the Centers for Disease Control and Prevention, Atlanta (C.M.J.).
Intussusception after Rotavirus Vaccine Introduction in India.
N Engl J Med
November 2020
From the Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences (S.N.R., N.P.N., V.T., S. Giri, I.P., S. Babji, S. Bidari, S. Senthamizh, G.K.), and the Department of Community Health (V.R.M.), Christian Medical College Vellore (T.J.K.J.), and Government Vellore Medical College (G.V.), Vellore, Kanchi Kamakoti Child Trust Hospital (B.S.), the National Institute of Epidemiology (G.K.C.P.), and the Institute of Child Health (P.D., M.J.), Chennai, Government Rajaji Hospital and Madurai Medical College, Madurai (K.M., H.B.), Coimbatore Medical College, Coimbatore (R.M., R. Gurusamy), the Indian Council of Medical Research, New Delhi (S. Giri, I.P., M.D.G.), Translational Health Science and Technology Institute, Faridabad (R.A., G.K.), Kurnool Medical College and Government General Hospital, Kurnool (S.M.), Government General Hospital and Rangaraya Medical College, Kakinada (K.B.G., B.R.), King George Hospital and Andhra Medical College, Visakhapatnam (P.P., R.P.G.), Sri Venkateshwara Medical College, Tirupati (M.B., V.M.), Sardar Valla Bhai Patel Post Graduate Institute of Paediatrics, Cuttack (S. Sathpathy, H.M.), the Institute of Medical Sciences and SUM Hospital, Bhubaneswar (M.D.), Kalinga Institute of Medical Sciences (N.K.M.) and Hi-Tech Hospital (R.K.R., P.M.), Bhubaneswar, Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences, Rohtak (G.G.), Shaheed Hasan Khan Mewati Government Medical College, Mewat (S.C.), Post Graduate Institute of Medical Education and Research, Chandigarh (M.G.), Sawai Man Singh Medical College, Jaipur (R. Gupta), Rabindranath Tagore Medical College, Udaipur (S. Goyal), Dr. Sampurnanand Medical College, Jodhpur (P.S.), Malankara Orthodox Syrian Church Medical College Hospital, Kolencherry (M.A.M.), Jawaharlal Nehru Institute of Post-graduate Medical Education and Research, Puducherry (S.K., A.S.), Mahatma Gandhi Memorial Medical College, Indore (H.J.), the Government Medical College, Guwahati, Assam (J.K.G.), King George Medical College, Lucknow (A.W.), and the Institute of Medical Sciences, Banaras Hindu University, Varanasi (V.G.) - all in India; and the Centers for Disease Control and Prevention, Atlanta (J.E.T., U.D.P.).
Background: A three-dose, oral rotavirus vaccine (Rotavac) was introduced in the universal immunization program in India in 2016. A prelicensure trial involving 6799 infants was not large enough to detect a small increased risk of intussusception. Postmarketing surveillance data would be useful in assessing whether the risk of intussusception would be similar to the risk seen with different rotavirus vaccines used in other countries.
View Article and Find Full Text PDFZika Virus Disease and Pregnancy Outcomes in Colombia.
N Engl J Med
August 2020
From Instituto Nacional de Salud (M.L.O., M.G., M.M., A.J.R, A.R., L.P., G.A., S.G., F.P., O.P.), Bogota, Colombia; and the Centers for Disease Control and Prevention (V.T.T., D.V., S.M.G., S.C.T., C.M.W., J.D.T., J.M.V., D.M.D., M.A.H.) and the Department of Gynecology and Obstetrics, Emory University School of Medicine (D.J.J.), Atlanta.
Background: In 2015 and 2016, Colombia had a widespread outbreak of Zika virus. Data from two national population-based surveillance systems for symptomatic Zika virus disease (ZVD) and birth defects provided complementary information on the effect of the Zika virus outbreak on pregnancies and infant outcomes.
Methods: We collected national surveillance data regarding cases of pregnant women with ZVD that were reported during the period from June 2015 through July 2016.
Hydroxychloroquine in Patients with Rheumatic Disease Complicated by COVID-19: Clarifying Target Exposures and the Need for Clinical Trials.
J Rheumatol
May 2020
From the Department of Rheumatology and Immunology, Duke University School of Medicine, Durham, North Carolina, USA; Duke Clinical Research Institute, Durham, North Carolina, USA; Department of Pediatrics, and the Division of Maternal-Fetal Medicine, Department of Obstetrics & Gynecology, Duke University School of Medicine, Durham, North Carolina, USA; Department of Pediatrics, Northwestern University, Feinberg School of Medicine, Evanston, Illinois, USA; Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. This study was supported by the Rheumatology Research Foundation's Scientist Development Award, the Thrasher Research Fund, the Childhood Arthritis and Rheumatology Research Alliance/Arthritis Foundation, the Derfner Foundation, NIGMS/NICHD (2T32GM086330-06), NICHD (5R01-HD076676-04, HHSN275201000003I), and a Duke Health/Private Diagnostic Clinic ENABLE grant. The Atherosclerosis Prevention in Pediatric Lupus Erythematosus [APPLE (ClinicalTrials. gov: NCT00065806)] trial is supported by the US National Institutes of Health (NIH) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) contract N01-AR-2-2265, the Edna and Fred L. Mandel Jr. Center for Hypertension and Atherosclerosis, and Pfizer, which provided atorvastatin and matching placebo. S.J.B. receives support from the NIH (5R01-HD076676-04, 1R01HD083003-01, HHSN275201000003I, HHSN275201800003I, HHSN272201500006I 5U24-TR001608-03), the US Food and Drug Administration (5U18FD006298-03), the Patient-Centered Outcomes Research Institute (PCORI), the Rheumatology Research Foundation's Scientist Development Award, the Thrasher Research Fund, and the Childhood Arthritis and Rheumatology Research Alliance/Arthritis Foundation. C.P.H. receives salary support for research from the National Institute for Child Health and Human Development (NICHD; 1K23HD090239; R13HD102136), National Heart Lung and Blood Institute (R61/R33HL147833), FDA (1R01-FD006099, PI: Laughon; and 5U18-FD006298, PI: Benjamin), the US government for his work in pediatric clinical pharmacology (Government Contract HHSN275201800003I, PI: Benjamin under the Best Pharmaceuticals for Children Act), the nonprofit Burrhoughs Wellcome Fund, and other sponsors for drug development in adults and children (dcri.org/about-us/ conflict-of-interest). D.G. receives support for research from the Eunice Kennedy Shriver NICHD (5R01HD096435). A.M. receives research support from the Thrasher Research Fund (www.thrasherresearch.org). L.E.S. receives support for research from the NIH (U19AR069522), PCORI (8177), and the Childhood Arthritis and Rheumatology Research Alliance. She is on the Data Safety Monitoring Board for investigational product trials for UCB (Cimzia) and Sanofi (sarilumab). Sanofi is a maker of hydroxychloroquine. Samples used in this publication were collected as part of NIH/NIAMS (N01-AR-2-2265). A.M.E. receives support from the NIH National Center for Advancing Translational Sciences. G.K.S. receives support for research from the NIH (UG1 HD068258‑06, HHSN272201300017I, 1UL1TR002553-01, R21AI132677) and the Centers for Disease Control and Prevention (200-2012-53663). She chairs an Independent Data Monitoring Committee for GlaxoSmithKline (RSV vaccine trials). M.C.W. receives support for research from the NIH (1R01-HD076676‑01A1 and 1K24-AI143971), National Institute of Allergy and Infectious Diseases (HHSN272201500006I and HHSN272201300017I), NICHD (HHSN275201000003I), FDA (5U18-FD006298), and the industry for drug development in adults and children. S.J. Balevic, MD, MHS, Department of Rheumatology and Immunology, and Department of Pediatrics, Duke University School of Medicine, and Duke Clinical Research Institute; C.P. Hornik, MD, PhD, Duke Clinical Research Institute, and Department of Pediatrics, Duke University School of Medicine; T.P. Green, MD, MS, Department of Pediatrics, Northwestern University, Feinberg School of Medicine; M.E. Clowse, MD, MPH, Department of Rheumatology and Immunology, Duke University School of Medicine; D. Gonzalez, PharmD, PhD, Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill; A.R. Maharaj, PhD, Duke Clinical Research Institute; L.E. Schanberg, MD, Duke Clinical Research Institute, and Department of Pediatrics, Duke University School of Medicine; A.M. Eudy, PhD, Department of Rheumatology and Immunology, Duke University School of Medicine; G.K. Swamy, MD, Division of Maternal-Fetal Medicine, Department of Obstetrics & Gynecology, Duke University School of Medicine; B.L. Hughes, MD, MSc, Division of Maternal-Fetal Medicine, Department of Obstetrics & Gynecology, Duke University School of Medicine; M. Cohen-Wolkowiez, MD, PhD, Duke Clinical Research Institute, and Department of Pediatrics, Duke University School of Medicine. Address correspondence to Dr. S.J. Balevic, Department of Rheumatology and Immunology, Duke University School of Medicine, 2301 Erwin Road, CHC, T-Level, Durham, North Carolina 27710, USA. E-mail: Full Release Article. For details see Reprints and Permissions at jrheum. org. Accepted for publication May 14, 2019.
Objective: To characterize hydroxychloroquine (HCQ) exposure in patients with rheumatic disease receiving longterm HCQ compared to target concentrations with reported antiviral activity against the coronavirus disease 2019 caused by SARS-CoV-2 (COVID-19).
Methods: We evaluated total HCQ concentrations in serum and plasma from published literature values, frozen serum samples from a pediatric systemic lupus erythematosus trial, and simulated concentrations using a published pharmacokinetic model during pregnancy. For each source, we compared observed or predicted HCQ concentrations to target concentrations with reported antiviral activity against SARS-CoV-2.
Consequences of Undervaccination - Measles Outbreak, New York City, 2018-2019.
N Engl J Med
March 2020
From the New York City Department of Health and Mental Hygiene, New York (J.R.Z., J.B.R., M.I., R.J.A., M.L.-E., N.M.V., J.L.R., B.M.I., A.J., M.A., S.C.H., T.G.M., M.O.K., B.M.M., D.C.D., O.B.), and the Centers for Disease Control and Prevention, Atlanta (J.R.Z., N.M.V.).
Article Synopsis
- Measles was eliminated in the U.S. in 2000, but an outbreak in 2018, linked to an unvaccinated child returning from Israel, resulted in 649 confirmed cases primarily within the Orthodox Jewish community in Brooklyn.
- The investigation included interviews, medical record reviews, and diagnostic testing, revealing that 85.8% of patients with known vaccination status were unvaccinated, with serious complications occurring in a small percentage of cases.
- Vaccination efforts increased MMR vaccine uptake in Williamsburg from 79.5% to 91.1% among children aged 12 to 59 months, while the total response cost to public health efforts was $8.4 million.
Covid-19 - Navigating the Uncharted.
N Engl J Med
March 2020
From the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD (A.S.F., H.C.L.); and the Centers for Disease Control and Prevention, Atlanta (R.R.R.).
Poverty and Health in Tennessee.
South Med J
January 2020
From the East Tennessee State University College of Public Health, Johnson City, and the Centers for Disease Control and Prevention, Atlanta, Georgia.
Objectives: Understanding the impact of poverty on health can inform efforts to target social programs and regional economic development. This study examined the effects of poverty on health among the 95 counties of Tennessee.
Methods: All of the counties of Tennessee were ranked by 5-year median household income, from the wealthiest to the poorest.
Universal Testing, Expanded Treatment, and Incidence of HIV Infection in Botswana.
N Engl J Med
July 2019
From the Botswana-Harvard AIDS Institute Partnership (J. Makhema, T.G., M.M., E.K., U.C., K. Manyake, A.M.M., S.V.S., R. Letlhogile, K. Mukokomani, E.W., S.M., K.M.P., S.L.D.-P., C.K., S.G., H.B., L.O., O.J., E.T.T., M.E., S.L.), the Botswana Ministry of Health and Wellness (R. Lebelonyane, S.E.-H.), and the Centers for Disease Control and Prevention (M.G.A., W.A., T.M., L.A.M., M.R.), Gaborone, Botswana; Harvard T.H. Chan School of Public Health (K.E.W., M.P.H., S.M., K.M.P., S.L.D.-P., V.N., S.G., R.L.S., H.M., V.D., Q.L., R.W., E.T.T., M.E., S.L.), Massachusetts General Hospital (K.M.P.), Brigham and Women's Hospital (S.L.D.-P., S.L.), and Harvard Pilgrim Health Care Institute (R.W.), Boston; Bennett Statistical Consulting, Ballston Lake, NY (K.B.); Goodtables Data Consulting, Norman, OK (J.L.); the Centers for Disease Control and Prevention (J. Moore, P.B., L.B., C.S., E.R., S.P.) and Intellectual Concepts (L.B.), Atlanta; and the Wharton School, University of Pennsylvania, Philadelphia (E.T.T.).
Background: The feasibility of reducing the population-level incidence of human immunodeficiency virus (HIV) infection by increasing community coverage of antiretroviral therapy (ART) and male circumcision is unknown.
Methods: We conducted a pair-matched, community-randomized trial in 30 rural or periurban communities in Botswana from 2013 to 2018. Participants in 15 villages in the intervention group received HIV testing and counseling, linkage to care, ART (started at a higher CD4 count than in standard care), and increased access to male circumcision services.
Protecting Mothers and Babies - A Delicate Balancing Act.
N Engl J Med
September 2018
From the University of Florida College of Medicine and College of Public Health and Health Professions, Gainesville (S.A.R.); and the Centers for Disease Control and Prevention, Atlanta (W.B., M.A.H.).
Risk of Spontaneous Abortion After Inadvertent Human Papillomavirus Vaccination in Pregnancy.
Obstet Gynecol
July 2018
HealthPartners Institute, Minneapolis, Minnesota; the Department of Obstetrics, Gynecology, & Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut; the Center for Health Research, Kaiser Permanente Northwest, Portland, Oregon; the Vaccine Study Center, Kaiser Permanente Northern California, Oakland, and the Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, California; the Institute for Health Research, Kaiser Permanente Colorado, Denver, Colorado; Marshfield Clinic Research Institute, Marshfield, Wisconsin; Kaiser Permanente Washington Health Research Institute, Seattle, Washington; Harvard Pilgrim Health Care Institute, Boston, Massachusetts; and the Centers for Disease Control and Prevention, Atlanta, Georgia.
Article Synopsis
- The study aimed to assess the risk of spontaneous abortion after receiving the quadrivalent HPV vaccine (4vHPV) before and during pregnancy, using data from seven health systems.
- It involved a retrospective cohort of women aged 12-27 who had pregnancies from 2008 to 2014 and compared the rates of spontaneous abortion across three timeframes: before pregnancy, close to pregnancy, and during pregnancy.
- Results showed no significant increase in spontaneous abortion risk for women vaccinated during pregnancy (8.6%) compared to those vaccinated earlier (10.4%), suggesting that 4vHPV vaccination is not associated with higher risks of pregnancy loss.
Hepatitis C in Injection-Drug Users - A Hidden Danger of the Opioid Epidemic.
N Engl J Med
March 2018
From the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD (T.J.L.); and the Centers for Disease Control and Prevention, Atlanta (J.W.W.).
Characterizing the Interrelationships of Prescription Opioid and Benzodiazepine Drugs With Worker Health and Workplace Hazards.
J Occup Environ Med
November 2017
The Division of Occupational Medicine, Department of Emergency Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania (Drs Kowalski-McGraw, Green-McKenzie); Geisinger Health, Wilkes Barre, Pennsylvania (Dr Kowalski-McGraw); and The Centers for Disease Control and Prevention/National Institute for Occupational Safety and Health (NIOSH), Cincinnati, Ohio (Drs Pandalai, Schulte).
Objective: Prescription opioid and benzodiazepine drug use, which has risen significantly, can affect worker health. Exploration of the scientific literature assessed (1) interrelationships of such drug use, occupational risk factors, and illness and injury, and (2) occupational and personal risk factor combinations that can affect their use.
Methods: The scientific literature from 2000 to 2015 was searched to determine any interrelationships.
Maternal and Infant Outcomes After Human Papillomavirus Vaccination in the Periconceptional Period or During Pregnancy.
Obstet Gynecol
September 2017
Department of Obstetrics, Gynecology, & Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut; HealthPartners Institute, Minneapolis, Minnesota; the Department of Epidemiology, University of Iowa, Iowa City, Iowa; the Center for Health Research, Kaiser Permanente Northwest, Portland, Oregon; the Vaccine Study Center, Kaiser Permanente Northern California, Oakland, California; the Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, California; Group Health Research Institute, Seattle, Washington; the Institute for Health Research, Kaiser Permanente Colorado and Ambulatory Care Services, Denver Health, Denver, Colorado; Harvard Pilgrim Health Care Institute & Harvard Medical School, Boston, Massachusetts; and the Centers for Disease Control and Prevention, Atlanta, Georgia.
Objective: To evaluate whether quadrivalent human papillomavirus vaccine (4vHPV) administered during the periconceptional period or during pregnancy was associated with increased risks for adverse obstetric events, adverse birth outcomes, or selected major structural birth defects.
Methods: We conducted a retrospective, observational cohort study using administrative and health care data from the Vaccine Safety Datalink. Insured women 13-27 years old with singleton pregnancies and a live birth from January 1, 2007, through September 1, 2013, who received 4vHPV during the periconceptional period (2 weeks before to 2 weeks after their last menstrual period), during pregnancy, or during both periods combined were compared with women who had a live birth during the same time period and received 4vHPV 4-18 months before their last menstrual period.
Transmission of Extensively Drug-Resistant Tuberculosis in South Africa.
N Engl J Med
January 2017
From the Emory University Rollins School of Public Health and School of Medicine (N.S.S., S.C.A., S.A., A.C., N.R.G.) and the Centers for Disease Control and Prevention (N.S.S.) - both in Atlanta; Albert Einstein College of Medicine and Montefiore Medical Center (N.S.S., J.C.M.B., N.R.G.), Columbia University Mailman School of Public Health (B.M., T.S.B.), and the American Museum of Natural History (A.N.) - all in New York; the National Institute for Communicable Diseases, Johannesburg (N.I., H.M., S.V.O.), University of KwaZulu-Natal and National Health Laboratory Service, Durban (P. Moodley, K.M., T.M., P. Mpangase), and the South African Medical Research Council, Cape Town (N.M., T.K.) - all in South Africa; and the Public Health Research Institute, New Jersey Medical School-Rutgers University, Newark (E.S., B.K.).
Background: Drug-resistant tuberculosis threatens recent gains in the treatment of tuberculosis and human immunodeficiency virus (HIV) infection worldwide. A widespread epidemic of extensively drug-resistant (XDR) tuberculosis is occurring in South Africa, where cases have increased substantially since 2002. The factors driving this rapid increase have not been fully elucidated, but such knowledge is needed to guide public health interventions.
View Article and Find Full Text PDFZika Virus Disease in Colombia - Preliminary Report.
N Engl J Med
August 2020
From Instituto Nacional de Salud (O.P., M.B., N.T., A.V.P., E.L.C., L.P., A.R., M.G., M.M., P.C., M.M.D., C.H., M.L.O.M.) and Ministerio de Salud y Protección Social (M.M.M., C.C.) - both in Bogota, Colombia; and the Centers for Disease Control and Prevention, Atlanta (C.A.N., D.V., S.L.F., V.T.T., A.E.-B., J.R., C.Y.R., A.M.P., R.H., D.J.J., M.A.H.).
Background: Colombia began official surveillance for Zika virus disease (ZVD) in August 2015. In October 2015, an outbreak of ZVD was declared after laboratory-confirmed disease was identified in nine patients.
Methods: Using the national population-based surveillance system, we assessed patients with clinical symptoms of ZVD from August 9, 2015, to April 2, 2016.
Ebola RNA Persistence in Semen of Ebola Virus Disease Survivors - Final Report.
N Engl J Med
October 2017
From the Sierra Leone Ministry of Health and Sanitation (G.F.D., F.Y., F.J., A.H.W., S.J.S., J.B., A.J.), the Sierra Leone Ministry of Defense (F.R.S., T.A.M., M.S.D., B.I., F.S.), and the Sierra Leone Ministry of Social Welfare, Gender, and Children's Affairs (T.D.) - all in Freetown, Sierra Leone; World Health Organization (N.B., S.L.R.M., J.E.M., P.G., N.H., A.E.T., A.A., A.C., M.C., T.W., F.K.E., D.N., A. Banerjee, K.N.D., M. Lamunu, S.L., P.F.) and the Joint United Nations Program on HIV/AIDS (P.O.), Geneva; Chinese Center for Disease Control and Prevention (W.X., H.L., W.L., Y.Z., Yongjian Liu, Yang Liu, K.X., G.W., M. Liang, Q.S., Y.H.) and Beijing Institute of Microbiology and Epidemiology (Y. Lan), Beijing; and the Centers for Disease Control and Prevention, Atlanta (B.K., E.E., C.R., K.B., J.K., N.A., S.D.B., E.M., T.M., B.R.E., A. Brault, J.W., T.S., S.T.N., O.M., U.S.).
Article Synopsis
- Ebola virus RNA was detected in the semen of 27% of male survivors of Ebola virus disease in Sierra Leone, with varying detection rates depending on the time since discharge from treatment.
- The study surveyed 220 male survivors with semen samples tested using RT-PCR methods, revealing a higher prevalence of viral RNA shortly after discharge and a significant decline over time.
- The findings highlight the need for further research into the potential risks of sexual transmission of Ebola, as the study did not directly assess this aspect.
Persistence of Ebola Virus in Ocular Fluid during Convalescence.
N Engl J Med
June 2015
From the Department of Medicine, Division of Infectious Diseases (J.B.V., C.S.K., G.M.L., A.K.M., B.S.R.), the Department of Ophthalmology (J.G.S., G.K., S.Y.), and the Department of Pathology and Laboratory Medicine (C.S.K.), Emory University School of Medicine, and the Centers for Disease Control and Prevention (M.H.K., S.W., U.S., T.M.U.) - both in Atlanta; the Infectious Diseases Institute, Mulago Hospital Complex, Kampala, Uganda (I.C.); and Flinders University, Adelaide, SA, Australia (J.R.S.).
Among the survivors of Ebola virus disease (EVD), complications that include uveitis can develop during convalescence, although the incidence and pathogenesis of EVD-associated uveitis are unknown. We describe a patient who recovered from EVD and was subsequently found to have severe unilateral uveitis during convalescence. Viable Zaire ebolavirus (EBOV) was detected in aqueous humor 14 weeks after the onset of EVD and 9 weeks after the clearance of viremia.
View Article and Find Full Text PDFDiabetes and periodontal therapy.
J Am Dent Assoc
December 2014
Dr. Buse is the Verne S. Caviness Distinguished Professor; chief, Division of Endocrinology; director, Diabetes Care Center; and the executive associate dean for clinical research, School of Medicine, University of North Carolina, Chapel Hill. He is past president for medicine and science of the American Diabetes Association and former chair of the National Diabetes Education Program, a joint effort of the National Institutes of Health (NIH) and the Centers for Disease Control and Prevention. He has had key roles in numerous multicenter clinical trials, including two major NIH-sponsored trials: Action to Control Cardiovascular Risk in Diabetes (ACCORD), for which he served as study vice-chair, and Studies to Treat or Prevent Pediatric Type 2 Diabetes (STOPP-TD2). He also is former associate editor of the American Diabetes Association journals Clinical Diabetes and Diabetes Care.
Sexual health education in medical school: a comprehensive curriculum.
Virtual Mentor
November 2014
Professor and director of the Program in Human Sexuality in the Department of Family Medicine and Community Health at the University of Minnesota Medical School in Minneapolis, and holds the first and only endowed academic chair in sexual health, and is the president of the Society for Sex Therapy and Research, and one of the founding editors of the International Journal of Transgenderism and the founding and current editor of the International Journal of Sexual Health, and a frequent technical consultant on sexual health issues to the World Health Organization (WHO), the Pan American Health Organization (the regional office of WHO), and the Centers for Disease Control and Prevention.
Clinical care of two patients with Ebola virus disease in the United States.
N Engl J Med
December 2014
From the Departments of Medicine (G.M.L., A.K. Mehta, J.B.V., C.S.K., B.S.R.), Pathology (C.S.K.), and Pediatrics (A.K. McElroy), Division of Infectious Diseases, Emory University School of Medicine, and the Centers for Disease Control and Prevention (A.K. McElroy, J.S.T., C.S., U.S., T.M.U.) - both in Atlanta; and Samaritan's Purse, Boone, NC (K.B., L.P.).
West Africa is currently experiencing the largest outbreak of Ebola virus disease (EVD) in history. Two patients with EVD were transferred from Liberia to our hospital in the United States for ongoing care. Malaria had also been diagnosed in one patient, who was treated for it early in the course of EVD.
View Article and Find Full Text PDFActionable diagnosis of neuroleptospirosis by next-generation sequencing.
N Engl J Med
June 2014
From the Departments of Biochemistry and Biophysics (M.R.W., J.L.D.), Neurology (M.R.W.), and Laboratory Medicine (S.N.N., E.S., G.Y., S.S., S.F., S.M., C.Y.C.), and the Department of Medicine, Division of Infectious Diseases (C.Y.C.), University of California, San Francisco (UCSF), and UCSF-Abbott Viral Diagnostics and Discovery Center (S.N.N., E.S., G.Y., S.S., S.F., S.M., C.Y.C.) - both in San Francisco; the Department of Medicine, Division of Allergy and Immunology (M.B., H.B., J.E.G.), and the Departments of Pathology and Laboratory Medicine (S.M.S., K.D.R.) and Pediatrics (T.L.M., C.M.S., S.L.H., J.E.G.), University of Wisconsin, Madison; the Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD (R.S., E.G., F.C.); the Departments of Pediatrics and Immunology, Division of Allergy and Immunology, Duke University, Durham, NC (R.H.B.); and the Centers for Disease Control and Prevention, Atlanta (R.G.).
A 14-year-old boy with severe combined immunodeficiency presented three times to a medical facility over a period of 4 months with fever and headache that progressed to hydrocephalus and status epilepticus necessitating a medically induced coma. Diagnostic workup including brain biopsy was unrevealing. Unbiased next-generation sequencing of the cerebrospinal fluid identified 475 of 3,063,784 sequence reads (0.
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