1 results match your criteria: "and from Liwan Central Hospital of Guangzhou (Tan)[Affiliation]"
Neuroprotective effects of all-trans-retinoic acid are mediated via downregulation of TLR4/NF-κB signaling in a rat model of middle cerebral artery occlusion.
Neurosciences (Riyadh)
October 2024
From the Department of Neurology (Tan, Chen, You, Li, Wen, Peng), and from First Affiliated Hospital of Guangdong Pharmaceutical College, and from Liwan Central Hospital of Guangzhou (Tan), Guangzhou, China.
Article Synopsis
- A study explored how all-trans-retinoic acid (ATRA) affects inflammation after a stroke, focusing on its molecular mechanisms.
- Researchers used rats who experienced a stroke and treated them with ATRA to evaluate its impact on neurological function, brain damage, and inflammatory responses.
- Results showed that ATRA reduced brain damage and improved recovery by decreasing inflammation and modifying microglial activation, possibly through the TLR4/NF-κB signaling pathway, suggesting its potential as a treatment for post-stroke inflammation.