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In vitro testing of daptomycin plus rifampin against methicillin-resistant Staphylococcus aureus resistant to rifampin.

Saudi Med J

December 2008

Department of Internal Medicine, King Hussein Cancer Center, Amman, Jordan, and formerly of Tulane Health Sciences Center, New Orleans, Louisiana, United States of America.

Objective: To test for synergy between daptomycin (DAP) and rifampin (RIF) against RIF-resistant methicillin-resistant Staphylococcus aureus (MRSA) isolates.

Methods: Synergy testing using time-kill assay (TKA) was performed on 6 clinically, and genetically unique RIF-resistant MRSA isolates. The isolates were identified out of 489 (1.

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