2 results match your criteria: "and Veterans Administrations Medical Center[Affiliation]"
Impaired fibrinolysis and traumatic brain injury in mice.
J Neurotrauma
June 2006
Traumatic Brain Injury Laboratory, Department of Neurosurgery, University of Pennsylvania School of Medicine, and Veterans Administrations Medical Center, Philadelphia, Pennsylvania 19106, USA.
Traumatic brain injury (TBI) has been associated with intravascular coagulation, which may be a result of thromboplastin released following brain injury. Clots thus formed are lysed by plasmin, which is activated by tissue-type and urokinase-type plasminogen activators (uPA). To evaluate the association between traumatic intravascular coagulation and post-traumatic outcome, uPA knockout (uPA-/-) transgenic mice (n=12) or wild-type littermates (WT; n=12) were anesthetized and subjected to controlled cortical impact (CCI) brain injury.
View Article and Find Full Text PDFInterleukin-10 modulates the severity of hypersensitivity pneumonitis in mice.
Am J Respir Cell Mol Biol
November 1998
Department of Medicine, University of Iowa College of Medicine, and Veterans Administrations Medical Center, Iowa City, Iowa, USA.
Hypersensitivity pneumonitis (HP) is an inflammatory lung disease characterized by granuloma formation. We recently showed that interferon-gamma (IFN-gamma) is essential for inflammation and granuloma formation in HP. Interleukin-10 (IL-10) counteracts many of the biologic effects of IFN-gamma, suggesting that IL-10 modulates inflammation and granuloma formation in HP.
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