A Reduction Active Theranostic Nanoparticle for Enhanced Near-Infrared Imaging and Phototherapy by Reducing Glutathione Level in Cancer Cells.

Facile preparation of a tumoral-stimuli-activated theranostic nanoparticle with simple constituents remains a challenge for tumor theranostic nanosystems. Herein we design a simple reductionresponsive turn-on theranostic nanoparticle for achieving fluorescent imaging and phototherapy combination. The theranostic nanoparticle is prepared by a simple one-step dialysis method of reduction active amphiphilic hyperbranched poly(-amidoamines) and a near-infrared (NIR) dye indocyanine green (ICG).

Hydrated cation-π interactions of π-electrons with hydrated Li, Na, and K cations.

Cation-π interactions are essential for many chemical, biological, and material processes, and these processes usually involve an aqueous salt solution. However, there is still a lack of a full understanding of the hydrated cation-π interactions between the hydrated cations and the aromatic ring structures on the molecular level. Here, we report a molecular picture of hydrated cation-π interactions, by using the calculations of density functional theory (DFT).

Regulating glucose metabolism using nanomedicines for cancer therapy.

The regulation of glucose metabolism is a research focus in cancer treatment. Glucose metabolism is essential for maintaining the growth and proliferation of tumor cells, thus offering us great opportunities for tumor treatment. Recently, much progress has been made in efficient cancer treatment by regulating the pathway of glucose metabolism with nanomedicines due to the rapid development of nanotechnology and promising drug targets.

Structures and absolute configurations of phomalones from the coral-associated fungus Parengyodontium album sp. SCSIO 40430.

Coral-associated microorganisms are likely to play an important role in host defense by the production of antimicrobials. Six new chromanones, namely, phomalichenones H-M (5, 6, and 8-11), and ten known analogues (1-4, 7, and 12-16) were isolated from the coral-associated fungus Parengyodontium album sp. SCSIO 40430.

Electrochemical ammonia synthesis from nitrite assisted by generated hydrogen atoms on a nickel phosphide catalyst.

Investigating green and effective means for ammonia synthesis is an important but challenging task. Electrochemical ammonia synthesis (EAS) from an indirect route (N2 → NOx → NH3) provides a feasible alternative strategy. The key step in this route is the reduction of NOx to NH3 instead of N2, which requires the investigation of efficient catalysts with high selectivity of NH3.

Hg(TeO)(SO): a new sulfate tellurite with a novel structure and large birefringence explored from d metal compounds.

Our exploration of novel inorganic solids with large birefringence in the d10 Metal-Te4+-SO42- system afforded four new sulfate tellurites, Ga2(TeO3)(SO4)(OH)2, In2(TeO3)2(SO4)(H2O), Zn4(Te3O7)2(SO4)2(H2O) and Hg3(Te3O8)(SO4). Notably, Hg3(Te3O8)(SO4) exhibits the largest birefringence at 532 nm (0.184) and 1064 nm (0.

Passive cancer targeting with a viral nanoparticle depends on the stage of tumorigenesis.

Tumor targeting with nanoparticles is a promising strategy for cancer diagnosis and treatment, especially for drug delivery to solid tumors. Previous studies mainly focused on nanoparticle design to improve their targeting efficiency, but few have investigated the impact of tumor progression stages on the targeting efficiency. Here, we used PEGylated viral nanoparticles (VNPs) of bacteriophage P22 to explore the relationship between targeting efficiency and tumor progression stages using a colorectal cancer model.

Interactions between water and rhodium clusters: molecular adsorption cluster adsorption.

Understanding metal-water interactions and hydrogen-bonding in water droplets is important but highly challenging. Various transition metals may serve as effective coordination centers to water; however, not in all cases is water bonded to a metal center as single molecules. We report here the observations of gas-phase rhodium clusters and their interactions with water.

A spin-1/2 gapped compound CdCu(SeO)Cl with a ladder structure.

The exploration of two-leg spin-ladder materials is a great challenge to the chemical community since it is one of the most ideal models for the study of low-dimensional magnetism and high-Tc superconductivity. Herein, we report on a successful synthesis of a new Cu2+-based two-leg ladder compound constructed by CuO4Cl2 octahedra along the [101] direction. The magnetic results exhibit a broad peak at Tmax ∼ 265 K, and suggest that CdCu2(SeO3)2Cl2 has a spin singlet ground state.

A flexible microfluidic strategy to generate grooved microfibers for guiding cell alignment.

Hydrogel microfibers are widely applied in tissue engineering and regenerative medicine due to their tunable morphology, componential anisotropy, and good biocompatibility. Specifically, grooved microfibers with unique advantages can facilitate cell alignment for mimicking the microstructures of myobundles. Herein, a microfluidic spinning system is proposed for flexibly generating grooved microfibers relying on the volume change after ionic crosslinking of sodium alginate (NaA) with different concentrations.

Self-assembly of shape-tunable oblate colloidal particles into orientationally ordered crystals, glassy crystals and plastic crystals.

The shapes of colloidal particles are crucial to self-assembled superstructures. Understanding the relationship between the shapes of building blocks and the resulting crystal structures is an important fundamental question. Here, we demonstrate that, by using particles whose shape interpolates between a flat disc and a sphere, not only are self-assembled superstructures but also their orientations sensitively dependent on the particle shape.

Tuning the shape and crystal phase of TiO nanoparticles for catalysis.

Synthesis of TiO nanoparticles with tunable shape and crystal phase has attracted considerable attention for the design of highly efficient heterogeneous catalysts. Tailoring the shape of TiO, in the crystal phases of anatase, rutile, brookite and TiO(B), allows tuning of the atomic configurations on the dominantly exposed facets for maximizing the active sites and regulating the reaction route towards a specific channel for achieving high selectivity. Moreover, the shape and crystal phase of TiO nanoparticles alter their interactions with metal species, which are commonly termed as strong metal-support interactions involving interfacial strain and charge transfer.

A 4-aminonaphthalimide-based fluorescent traceable prodrug with excellent photoinduced cytotoxicity.

A blue light activated anti-cancer prodrug, NST, was designed based on a photoactive 4-aminonaphthalimide derivative and an anticancer drug, 10-hydroxycamptothecin. NST was hard to be taken up by living cells and showed negligible dark cytotoxicity. The irradiation caused photocleavage of NST and resulted in high cytotoxicity.

Kinetics of CHOO and -CHCHOO reaction with acrolein.

The kinetics for the reactions of CH2OO and syn-CH3CHOO with acrolein, a typical unsaturated aldehyde in the atmosphere, were studied in a flash photolysis flow reactor using the OH laser-induced fluorescence (LIF) method. The bimolecular reaction rate coefficients were measured at temperatures ranging from 281 to 318 K, and pressures ranging from 5 to 200 Torr. No obvious dependence of the rate coefficients on pressure was observed under the current experimental conditions.

Assembling gold nanobipyramids into chiral plasmonic nanostructures with DNA origami.

Herein, we report the assembly of gold nanobipyramids (AuNBPs) into static and dynamic chiral plasmonic nanostructures via DNA origami. Compared with conventional chiral dimers of gold nanorods (AuNRs), AuNBP dimers exhibit more intriguing chiroptical responses, suggesting that they could be a superior alternative for constructing chiral plasmonic nanostructures for biosensing.

Targeted perfusion adsorption for hyperphosphatemia using mixed matrix microspheres (MMMs) encapsulated NH-MIL-101(Fe).

Hyperphosphatemia, a common complication of chronic renal failure patients, is described as an excess amount of serum phosphate >4.5 mg dL-1. Current therapy for hyperphosphatemia is limited by low removal efficiency, secondary hyperparathyroidism, uremic bone disease, and the promotion of vascular and visceral calcifications.

Geometric, electronic, and optical properties of MoS/WSSe van der Waals heterojunctions: a first-principles study.

Van der Waals (vdW) heterojunctions constructed by vertical stacking two-dimensional transition metal dichalcogenides hold exciting promise in realizing future atomically thin electronic and optoelectronic devices. Recently, a Janus WSSe structure has been successfully synthesized by using chemical vapor deposition, selective epitaxy atomic replacement, and pulsed laser deposition methods. Herein, based on first-principles calculations, we introduce the structures and performances of MoS/WSSe vdW heterojunctions with different interfaces and stacking modes.

Theoretical investigation of defective MXenes as potential electrocatalysts for CO reduction toward C products.

Electrochemical CO2/CO conversion to valuable chemical products is an attractive strategy for storage of clean energy and control of greenhouse gas emission. Currently, CO2 reduction to CO is relatively mature, whereas the deep reduction and further conversion of CO into multi-carbon products, such as ethylene (C2H4) and ethanol (C2H5OH), are highly challenging. Based on the density functional theory (DFT) calculations, we explored the possibility of CO reduction reaction (CORR), to obtain C2 products, with defective MXenes in which the defect is created by removing two neighboring oxygen atoms on the surface.

Insights into electrocatalysis by scanning tunnelling microscopy.

Understanding the mechanism of electrocatalytic reaction is important for the design and development of highly efficient electrocatalysts for energy technology. Investigating the surface structures of electrocatalysts and the surface processes in electrocatalytic reactions at the atomic and molecular scale is helpful to identify the catalytic role of active sites and further promotes the development of emerging electrocatalysts. Since it was invented, scanning tunnelling microscopy (STM) has become a powerful technique to investigate surface topographies and electronic properties at the nanoscale resolution.

Rh-Catalyzed cascade C-H activation/C-C cleavage/cyclization of carboxylic acids with cyclopropanols.

Merging both C-H and C-C activation in a tandem process is a marked challenge. A novel Rh(iii)-catalyzed C-H activation/ring opening C-C cleavage/cyclization of carboxylic acids with cyclopropanols was developed for the synthesis of 3-substituted phthalides and α,β-butenolides. This reaction displays excellent functional group tolerance with respect to both carboxylic acids and cyclopropanols and features relatively mild conditions.

Real-time red blood cell counting and osmolarity analysis using a photoacoustic-based microfluidic system.

Counting the number of red blood cells (RBCs) in blood samples is a common clinical diagnostic procedure, but conventional methods are unable to provide the size and other physical properties of RBCs at the same time. In this work, we explore photoacoustic (PA) detection as a rapid label-free and noninvasive analysis technique that can potentially be used for single RBC characterization based on their photoabsorption properties. We have demonstrated an on-chip PA flow cytometry system using a simple microfluidic chip combined with a PA imaging system to count and characterize up to ∼60 RBCs per second.

Mannose modified zwitterionic polyester-conjugated second near-infrared organic fluorophore for targeted photothermal therapy.

Cancer resistance has been the huge challenge to clinical treatment. A photothermal therapy of second near-infrared (NIR-II) organic dye small molecule has been used to conquer the cancer resistance. However, the available NIR-II dye lacks selectivity and spreads throughout the body.

Large-scale reconfiguration of connectivity patterns among attentional networks during context-dependent adjustment of cognitive control.

The ability to adjust our behavior flexibly depending on situational demands and changes in the environment is an important characteristic of cognitive control. Previous studies have proved that this type of adaptive control plays a crucial role in selective attention, but have barely explored whether and how attentional networks support adaptive control. In the present study, a Stroop task with a different proportion of incongruent trials was used to investigate the brain activity and connectivity of six typical attentional control networks (i.

UCNP@BSA@Ru nanoparticles with tumor-specific and NIR-triggered efficient PACT activity .

Ru(ii)-based photoactivated chemotherapy (PACT) agents are promising; however, their short wavelength absorption (generally <550 nm) and poor tumor accumulation ability limit their in vivo applications. Herein, bovine serum albumin (BSA) coated lanthanide-doped upconversion nanoparticles (NaYF4:Yb:Tm@NaYF4 (UCNPs)) were loaded with a Ru(ii) PACT agent, i.e.

A nano-integrated microfluidic biochip for enzyme-based point-of-care detection of creatinine.

A nano-integrated portable enzymatic microfluidic electrochemical biochip was developed for single-step point-of-care testing of creatinine. The biochip could automatically eliminate a lot of interferences from practical biological samples and enzymatic intermediate products. Gold nanostructure- and carbon nanotube-based screen-printed carbon electrodes were integrated into microfluidic structures to improve the detection performance for creatinine.