357 results match your criteria: "and Trinity College Institute of Neuroscience[Affiliation]"
Sci Bull (Beijing)
February 2025
Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai 200433, China; Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, Shanghai 200433, China; Department of Computer Science, University of Warwick, Coventry CV4 7AL, UK; Zhangjiang Fudan International Innovation Center, Shanghai 200433, China; Fudan ISTBI-ZJNU Algorithm Centre for Brain-inspired Intelligence, Zhejiang Normal University, Hangzhou 321004, China. Electronic address:
Biol Psychiatry
February 2025
Department of Psychiatry, Yale School of Medicine, New Haven, CT; Child Study Center, Yale School of Medicine, New Haven, CT.
Background: Cannabis use is common, particularly during emerging adulthood when brain development is ongoing, and its use is associated with harmful outcomes for a subset of people. An improved understanding of the neural mechanisms underlying risk for problem-level use is critical to facilitate the development of more effective prevention and treatment approaches.
Methods: The current study applied a whole-brain, data-driven, machine-learning approach to identify neural features predictive of problem-level cannabis use in a non-clinical sample of college students (n=191, 58% female) based on reward task functional connectivity data.
Mol Psychiatry
February 2025
National Clinical Research Center for Aging and Medicine at Huashan Hospital, Institute of Science and Technology for Brain-Inspired Intelligence, School of Life Sciences, Fudan University, Shanghai, 200433, China.
Laboratory studies show brain maturation involves synaptic pruning and cognitive development. Human studies suggest links between early cognitive performance and later mental health, but inconsistencies remain. It is unclear if specific brain regions mediate this relationship, and the molecular underpinnings are not well understood.
View Article and Find Full Text PDFMounting evidence suggests hierarchical psychopathology factors underlying psychiatric comorbidity. However, the exact neurobiological characterizations of these multilevel factors remain elusive. In this study, leveraging the brain-behavior predictive framework with a 10-year longitudinal imaging-genetic cohort (IMAGEN, ages 14, 19 and 23, = 1,750), we constructed two neural factors underlying externalizing and internalizing symptoms, which were reproducible across six clinical and population-based datasets (ABCD, STRATIFY/ESTRA, ABIDE II, ADHD-200 and XiNan, from age 10 to age 36, = 3,765).
View Article and Find Full Text PDFNat Ment Health
January 2025
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Unhealthy eating, a risk factor for eating disorders (EDs) and obesity, often coexists with emotional and behavioral problems; however, the underlying neurobiological mechanisms are poorly understood. Analyzing data from the longitudinal IMAGEN adolescent cohort, we investigated associations between eating behaviors, genetic predispositions for high body mass index (BMI) using polygenic scores (PGSs), and trajectories (ages 14-23 years) of ED-related psychopathology and brain maturation. Clustering analyses at age 23 years ( = 996) identified 3 eating groups: restrictive, emotional/uncontrolled and healthy eaters.
View Article and Find Full Text PDFNat Commun
January 2025
Department of Neurology and National Center for Neurological Disorders, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai, China.
Brain glymphatic activity, as indicated by diffusion-tensor imaging analysis along the perivascular space (ALPS) index, is involved in developmental neuropsychiatric and neurodegenerative diseases, but its genetic architecture is poorly understood. Here, we identified 17 unique genome-wide significant loci and 161 candidate genes linked to the ALPS-indexes in a discovery sample of 31,021 individuals from the UK Biobank. Seven loci were replicated in two independent datasets.
View Article and Find Full Text PDFAddiction
January 2025
Department of Psychiatry, University of Vermont, Burlington, Vermont, USA.
Background And Aim: Cannabis use disorder (CUD) is strongly influenced by genetic factors; however the mechanisms underpinning this association are not well understood. This study investigated whether a polygenic risk score (PRS) based on a genome-wide association study for CUD in adults predicts cannabis use in adolescents and whether the association can be explained by inter-individual variation in structural properties of brain white matter or risk-taking behaviors.
Design And Setting: Longitudinal and cross-sectional analyses using data from the IMAGEN cohort, a European longitudinal study integrating genetic, neuroimaging and behavioral measures.
J Affect Disord
December 2024
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, London SE5 8AF, UK. Electronic address:
Biol Psychiatry
November 2024
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom. Electronic address:
Sci Adv
November 2024
School of Data Science, Fudan University, Shanghai, China.
Bio Protoc
November 2024
School of Genetics and Microbiology, and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
Long-lasting memories are a core aspect of an animal's life. Such memories are characterized by unique molecular mechanisms and often unique circuitry, neither of which are completely understood in vivo. The deep knowledge of the identity and connectivity of neurons of the fruit fly , as well as the sophisticated genetic tools that allow in vivo perturbations and physiology monitoring, make it a remarkably useful organism in which to investigate the molecular mechanisms of long-term memories.
View Article and Find Full Text PDFBackground: Psychotic symptoms in adolescence are associated with social adversity and genetic risk for schizophrenia. This gene-environment interplay may be mediated by personality, which also develops during adolescence. We hypothesized that (i) personality development predicts later Psychosis Proneness Signs (PPS), and (ii) personality traits mediate the association between genetic risk for schizophrenia, social adversities, and psychosis.
View Article and Find Full Text PDFElife
October 2024
Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.
bioRxiv
September 2024
National Clinical Research Center for Aging and Medicine at Huashan Hospital, MOE Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai 200433, China.
bioRxiv
September 2024
Interdepartmental Neuroscience Program, Yale University, New Haven, Connecticut.
Neural variability, or variation in brain signals, facilitates dynamic brain responses to ongoing demands. This flexibility is important during development from childhood to young adulthood, a period characterized by rapid changes in experience. However, little is known about how variability in the engagement of recurring brain states changes during development.
View Article and Find Full Text PDFNat Commun
September 2024
Institute of Neuroscience and Medicine, Brain & Behaviour (INM-7), Research Centre Jülich, Jülich, Germany.
Human brain morphology undergoes complex changes over the lifespan. Despite recent progress in tracking brain development via normative models, current knowledge of underlying biological mechanisms is highly limited. We demonstrate that human cortical thickness development and aging trajectories unfold along patterns of molecular and cellular brain organization, traceable from population-level to individual developmental trajectories.
View Article and Find Full Text PDFElife
September 2024
School of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland.
Nat Commun
July 2024
School of Data Science, Fudan University, Shanghai, China.
Adolescents exhibit remarkable heterogeneity in the structural architecture of brain development. However, due to limited large-scale longitudinal neuroimaging studies, existing research has largely focused on population averages, and the neurobiological basis underlying individual heterogeneity remains poorly understood. Here we identify, using the IMAGEN adolescent cohort followed up over 9 years (14-23 y), three groups of adolescents characterized by distinct developmental patterns of whole-brain gray matter volume (GMV).
View Article and Find Full Text PDFMol Psychiatry
December 2024
Ecole Normale Supérieure Paris-Saclay, University Paris-Saclay, University Paris-City, INSERM U1299 "Developmental Trajectories & Psychiatry, Centre Borelli CNRS UMR9010, Gif-sur-Yvette, France.
Perseverative negative thoughts, known as rumination, might arise from emotional challenges and preclude mental health when transitioning into adulthood. Due to its multifaceted nature, rumination can take several ruminative response styles, that diverge in manifestations, severity, and mental health outcomes. Still, prospective ruminative phenotypes remain elusive insofar.
View Article and Find Full Text PDFbioRxiv
June 2024
Institute of Neuroscience and Medicine - Brain and Behaviour (INM-7), Research Centre Jülich, Jülich, Germany.
J Affect Disord
September 2024
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF, United Kingdom. Electronic address:
Background: Personality traits have been associated with eating disorders (EDs) and comorbidities. However, it is unclear which personality profiles are premorbid risk rather than diagnostic markers.
Methods: We explored associations between personality and ED-related mental health symptoms using canonical correlation analyses.
J Affect Disord
August 2024
Department of Psychology, University of Amsterdam, Amsterdam, the Netherlands.
Background: Depressive symptoms are highly prevalent, present in heterogeneous symptom patterns, and share diverse neurobiological underpinnings. Understanding the links between psychopathological symptoms and biological factors is critical in elucidating its etiology and persistence. We aimed to evaluate the utility of using symptom-brain network models to parse the heterogeneity of depressive complaints in a large adolescent sample.
View Article and Find Full Text PDFbioRxiv
June 2024
School of Psychology and Global Brain Health Institute, Trinity College Dublin, Ireland.
Substance use, including cigarettes and cannabis, is associated with poorer sustained attention in late adolescence and early adulthood. Previous studies were predominantly cross-sectional or under-powered and could not indicate if impairment in sustained attention was a predictor of substance-use or a marker of the inclination to engage in such behaviour. This study explored the relationship between sustained attention and substance use across a longitudinal span from ages 14 to 23 in over 1,000 participants.
View Article and Find Full Text PDFPsychopharmacology (Berl)
July 2024
Laboratory of Neuropsychophysiology, Faculty of Psychology and Educational Sciences (Laboratory of Neuropsychophysiology), University of Porto, Rua Alfredo Allen, 4200-135, Porto, Portugal.