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SIRT1 downregulation in pneumonia is associated with an immature neutrophil response and increased disease severity.
J Trauma Acute Care Surg
April 2024
From the Division of Trauma, Critical Care, and Burn at The Ohio State University Wexner Medical Center (H.E.L., K.M.S., J.H., N.W., E.C.P., C.A.S.), Department of Neurology at The Ohio State University Wexner Medical Center (J.A.S., A.R.S.), The Ohio State University, and The Ohio State University (N.W., E.C.P.), Columbus, Ohio.
Background: Pneumonia remains a common complication in trauma patients. Sirtuin 1 (SIRT1) is an anti-inflammatory NAD + -dependent deacetylase that has been shown to reduce the severity of ARDS in polymicrobial sepsis. The impact of SIRT1 in acute pneumonia, however, remains unknown.
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