Inhibitory effects of oolong tea polyphenols on pancreatic lipase in vitro.

Fifty-four polyphenols isolated from tea leaves were evaluated for their inhibitory activities against pancreatic lipase, the key enzyme of lipid absorption in the gut. (-)-Epigallocatechin 3-O-gallate (EGCG), which is one of major polyphenols in green tea, showed lipase inhibition with an IC50 of 0.349 microM.

Colopsinol A, a Novel Polyhydroxyl Metabolite from Marine Dinoflagellate Amphidinium sp.

Colopsinol A (1), a novel polyhydroxyl compound, has been isolated from the cultured marine dinoflagellate Amphidinium sp., from which a number of cytotoxic macrolides, amphidinolides, have been obtained to date, and the gross structure of 1 was elucidated on the basis of extensive spectroscopic analyses including recent 2D NMR techniques of CH(2)-selected editing HSQC as well as FABMS/MS experiments and chemical means. Colopsinol A (1), C(71)H(119)O(25)SNa, is the first member of a new class of polyketide natural products possessing a gentiobioside moiety and a sulfate ester.