67 results match your criteria: "and St. Luke's Episcopal Hospital[Affiliation]"

Long-term Relugolix Combination Therapy for Symptomatic Uterine Leiomyomas.

Obstet Gynecol

December 2022

University of Chicago, Chicago, Illinois; Carolina Woman's Wellness Center, Durham, North Carolina; Baylor College of Medicine and St. Luke's Episcopal Hospital, Houston, Texas; University Magna Graecia, Catanzaro, Italy; Instituto de Investigaciones Materno Infantil (IDIMI), University of Chile, Santiago, Chile; McKain Consulting, LLC, Las Vegas, Nevada; Myovant Sciences Inc., Brisbane, California; and Mayo Clinic and Mayo Clinic Alix School of Medicine, Rochester, Minnesota.

Objective: In the LIBERTY 1 and LIBERTY 2 placebo-controlled trials, once-daily relugolix combination therapy reduced menstrual blood loss volume and pain in women with heavy menstrual bleeding associated with uterine leiomyomas and was well tolerated, with preservation of bone mineral density (BMD) through 24 weeks. Here we report the long-term efficacy and safety of relugolix combination therapy treatment for up to 52 weeks.

Methods: Women with uterine leiomyoma-associated heavy menstrual bleeding who completed any treatment arm in either the LIBERTY 1 or LIBERTY 2 trial were eligible to enroll in a 28-week long-term extension study.

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Heyde syndrome is characterized by an association between gastrointestinal (GI) bleeding and calcific aortic stenosis (AS). Although the course of disease progression that links AS and GI bleeding has not been determined, overlaps among AS, intestinal dysplasia, and acquired von Willebrand's syndrome are thought to result in GI bleeding. Aortic valve repair in some patients has been reported to result in marked improvement or the complete resolution of signs and symptoms of Heyde syndrome.

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Multimodality imaging for pre-clinical assessment of Fabry's cardiomyopathy.

Eur Heart J Cardiovasc Imaging

October 2014

Department Cuore e Grossi Vasi Attilio Reale, Sapienza University in Rome, Policlinico Umberto I, Rome, Italy.

Anderson Fabry's disease (AFD) is a rare but underdiagnosed intracellular lipid disorder which can cause left ventricular hypertrophy (LVH). Pre-clinical diagnosis of Fabry's disease is important as it permits early stratification for enzyme replacement therapy, improving the patient's long-term prognosis, avoiding progression to irreversible fibrosis, and preventing cardiovascular complications. Combinations of imaging modalities that integrate the strengths of each modality and at the same time eliminate weaknesses of an individual modality can offer improved diagnostics, therapeutic monitoring, and pre-clinical assessment of Fabry's disease.

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All men with vasculogenic erectile dysfunction require a cardiovascular workup.

Am J Med

March 2014

Andrology Research Unit, Developmental & Regenerative Biomedicine Research Group, University of Manchester, Manchester Academic Health Science Centre, Manchester Royal Infirmary, UK.

An association between erectile dysfunction and cardiovascular disease has long been recognized, and studies suggest that erectile dysfunction is an independent marker of cardiovascular disease risk. Therefore, assessment and management of erectile dysfunction may help identify and reduce the risk of future cardiovascular events, particularly in younger men. The initial erectile dysfunction evaluation should distinguish between predominantly vasculogenic erectile dysfunction and erectile dysfunction of other etiologies.

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The concept of electrical protection of the ischemic myocardium is in constant evolution and has recently been supported by experimental and clinical studies. Historically, antiplatelet agents, angiotensin-converting enzyme inhibitors, β-blockers, and statins have been all proposed as drugs conferring anti-ischemic cardioprotection. This was supported by the evidence consistently indicating that all these drugs were capable of reducing mortality and the risk of repeat myocardial infarction.

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Nicotine and insulin resistance: when the smoke clears.

Diabetes

December 2012

Diabetes, Endocrinology and Metabolism Division, Department of Medicine, Baylor College of Medicine, Houston, Texas, and St. Luke’s Episcopal Hospital, Houston, Texas, USA.

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Diastolic segmental compression of a native coronary artery is an uncommon cause of chest pain. Here we describe a 24-year-old woman with constrictive pericarditis who had retrosternal chest pain, progressive dyspnea, tachycardia, and bilateral leg edema. She was diagnosed with compression of the first and second obtuse marginal branches of left circumflex coronary artery secondary to constrictive pericarditis.

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Liver transplantation in autoimmune liver diseases.

Best Pract Res Clin Gastroenterol

December 2011

Fellow in Hepatology and Liver Transplantation, Liver Center, Baylor College of Medicine and St. Luke's Episcopal Hospital, 1709 Dryden, Suite 1500, Houston, TX 77030, USA.

Liver transplantation is indicated for terminal phases of autoimmune hepatitis, primary biliary cirrhosis and primary sclerosing cholangitis. Indications for transplantation in autoimmune liver diseases are similar to those used in other acute or chronic liver diseases. Therapeutic advances have reduced the need for transplantation for autoimmune hepatitis and primary biliary cirrhosis but not for primary sclerosing cholangitis.

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HIV infection and the liver: the importance of HCV-HIV coinfection and drug-induced liver injury.

Clin Liver Dis

February 2011

Hepatology and Liver Transplantation Program, Baylor College of Medicine, and St Luke's Episcopal Hospital, Houston, TX, USA.

Hepatitis C virus-Human immunodeficiency virus (HCV-HIV) coinfections are identified in up to 30% of patients infected with HIV and in 8% of patients infected with HCV. Now that progression of HIV and deaths due to AIDS can be prevented by highly active antiretroviral therapy (HAART), it is clear that HCV coinfection is associated with accelerated progression to cirrhosis and increased liver-related morbidity and mortality. Antiviral therapy with pegylated interferon and ribavirin for HCV in HCV-HIV coinfected patients is less successful than in patients with HCV monoinfection, and HAART can cause drug-induced liver injury.

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Context: Symptoms and signs consistent with androgen deficiency and low testosterone levels are recognized frequently in clinical practice. Recent population-based epidemiological studies indicate that low testosterone levels in men are associated with increased morbidity and mortality. The clinician must be able to counsel patients to help them determine whether testosterone replacement therapy is appropriate for them.

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Bacteria producing Klebsiella pneumoniae carbapenemases (KPCs) are rapidly emerging as a cause of multidrug-resistant infections worldwide. Bacterial isolates harbouring these enzymes are capable of hydrolysing a broad spectrum of beta-lactams including the penicillins, cephalosporins, carbapenems and monobactam. Detection of isolates harbouring carbapenemases can be inconsistent using automated systems, often requiring subsequent confirmatory tests.

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Purpose: To report endoluminal repair of aortic coarctation in a patient with a chronic type B aortic dissection presenting with an expanding pseudoaneurysm after failure of surgical repair.

Case Report: This 30-year-old man with a congenital coarctation of the aorta suffered an iatrogenic type B aortic dissection during angiography at the age of 6. Emergent surgery at that time included a left subclavian artery-to-distal thoracic aorta surgical conduit; the coarctation itself was not repaired.

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Practical issues on the use of enoxaparin in elective and emergent percutaneous coronary intervention.

J Invasive Cardiol

September 2008

Department of Medicine-Cardiology, Baylor College of Medicine and St. Luke's Episcopal Hospital/Texas Heart Institute, 1709 Dryden Road, BCM 620, Suite 9.85, Houston, TX 77030, USA.

Unfractionated heparin (UFH) has been the standard choice of adjunctive antithrombotic therapy during elective percutaneous coronary intervention (PCI). Evidence is emerging that intravenous (IV) enoxaparin may offer similar benefits to UFH in terms of ischemic events or death, but with the benefit of reduced major bleeding risk. In addition, enoxaparin has pharmacological and practical advantages that can simplify patient management.

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Atherosclerosis is now recognized as an inflammatory disease involving the vascular wall. Recent results indicate that acute inflammation does not simply passively resolve as previously assumed but is actively terminated by a homeostatic process that is governed by specific lipid-derived mediators initiated by lipoxygenases. Experiments with animals and humans support a proinflammatory role for the 5-lipoxygenase system.

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Loperamide plus azithromycin more effectively treats travelers' diarrhea in Mexico than azithromycin alone.

J Travel Med

January 2008

Department of Medicine, Division of Infectious Diseases, University of Texas Medical School at Houston, and St Luke's Episcopal Hospital, Houston, TX 77030, USA.

Background: Because the combination of loperamide and some antimicrobials has proven to be more efficacious than the antimicrobial agent alone in the treatment of travelers' diarrhea, we set out to prove loperamide plus azithromycin was more efficacious than azithromycin alone.

Methods: During the summers of 2002 to 2003, 176 US adults recently arrived in Guadalajara, Mexico were enrolled in a prospective, double-blinded, randomized trial of the treatment of acute diarrhea. Subjects received single doses (1,000 or 500 mg) of azithromycin or a single 500 mg dose of azithromycin plus loperamide.

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Laparoscopic approach for the retrieval of retained video capsule endoscopy.

JSLS

July 2007

Section of Minimally Invasive Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, and St. Luke's Episcopal Hospital, Houston, Texas, USA.

Video capsule endoscopy is now a first-line tool in evaluating and diagnosing gastrointestinal bleeding, inflammatory bowel disease, and small bowel neoplasms. Capsule nonpassage or retention is an uncommon but clinically significant occurrence. How to best retrieve these retained capsules is currently being debated.

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Phylogenetic comparisons reveal multiple acquisitions of the toxin genes by enterotoxigenic Escherichia coli strains of different evolutionary lineages.

J Clin Microbiol

December 2006

Division of Immunity and Infection, The Medical School, The University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom, and St. Luke's Episcopal Hospital, Houston, TX 77083, USA.

Escherichia coli is a diverse bacterial species which is widely distributed in the environment but also exists as a commensal and pathogen of different host species. Human intestinal pathogenic E. coli causes over 160 million cases of diarrhea and an estimated 1 million deaths per year.

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Prevalence of diarrhea at a university hospital and association with modifiable risk factors.

Ann Pharmacother

June 2006

College of Pharmacy, Department of Clinical Sciences and Administration, University of Houston, and St. Luke's Episcopal Hospital, TX 77030, USA.

Objective: To assess the prevalence of diarrhea at a university-affiliated medical center and the presence of modifiable risk factors.

Methods: A point prevalence survey was conducted. All patients hospitalized for more than 24 hours were asked if they were experiencing diarrhea.

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Aim: The aim of this study was to assess understanding of genetics and attitudes towards genetic testing for clinical and research purposes in a group of older adults in the UK.

Background: Increasingly, genomics will have an impact on the diagnosis, prevention and treatment of common diseases and the prescription of drugs. The chance of being affected by a medical condition increases with age and therefore the use of genetic testing as part of general health-care practice has an impact on the older population.

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Acute anterior spinal cord ischemia is a rare but disastrous complication of endovascular aortic procedures. Although intravenous thrombolysis with recombinant tissue plasminogen activator is an effective treatment for acute brain ischemia, its use for the treatment of spinal cord ischemia has not previously been reported. We report the case of a patient who developed anterior spinal cord ischemia during diagnostic aortography He was treated with intravenous recombinant tissue plasminogen activator within 3 hours after the onset of symptoms.

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Aneurysm sac re-expansion after thrombolysis.

J Endovasc Ther

February 2006

Department of Cardiovascular Surgery, Texas Heart Institute and St. Luke's Episcopal Hospital, Houston, Texas 77030, USA.

Purpose: To present a case of delayed abdominal aortic aneurysm (AAA) re-expansion after thrombolysis for endograft limb occlusion.

Case Report: A 68-year-old man underwent AAA exclusion with an AneuRx stent-graft in 1999. Five years later, he developed right limb thrombosis of the endograft.

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Carotid stenting.

Tex Heart Inst J

January 2006

Peripheral Vascular Disease Service, Texas Heart Institute and St. Luke's Episcopal Hospital, Houston, Texas 77030, USA.

From my point of view, carotid artery stenting, in 2005, is clearly here to stay. "Houston, the Eagle has landed." The rest is up to you and me as we encourage our surgical colleagues and our various medical Societies to embrace this safe, effective, and durable technology and make it available to the patients who will really benefit from it.

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