EyeHealer: A large-scale anterior eye segment dataset with eye structure and lesion annotations.

Anterior segment eye diseases account for a significant proportion of presentations to eye clinics worldwide, including diseases associated with corneal pathologies, anterior chamber abnormalities (e.g. blood or inflammation), and lens diseases.

Autoimmune Hepatitis with Elevated Serum IgG4 Levels Have a High Prevalence of Cirrhosis at Diagnosis.

Background: Some autoimmune hepatitis (AIH) patients have elevated serum IgG4 levels, and the clinical characteristics of such patients are currently incompletely characterized.

Aim: To analyze the clinical features and possible pathogenesis of AIH with elevated serum IgG4 levels.

Methods: According to their serum IgG4 value, patients were divided into elevated IgG4 (IgG4 > 1.

Dry storage of mammalian spermatozoa and cells: state-of-the-art and possible future directions.

This review provides a snapshot of the current state-of-the-art of drying cells and spermatozoa. The major successes and pitfalls of the most relevant literature are described separately for spermatozoa and cells. Overall, the data published so far indicate that we are closer to success in spermatozoa, whereas the situation is far more complex with cells.

Late puerperal hemorrhage of a patient with Klippel-Trenaunay syndrome: A case report.

Introduction: The Klippel-Trenaunay syndrome (KTS) is a rare congenital disorder. The obstetric course of women with KTS varies. Complications include bleeding, disseminated intravascular coagulation (DIC), thromboembolic events, etc.

Evaluating the effectiveness of a disaster preparedness nursing education program in Chengdu, China.

Objective: To develop and evaluate a disaster nursing preparedness training program to improve nursing students' ability in disaster fundamentals, triage, and family preparedness when facing a disaster.

Design And Sample: An experimental study was applied using a pretest and post-test control group design. Participants were randomly assigned to the experimental (n = 31) and control (n = 32) groups.

Novel hybrid molecule overcomes the limited response of solid tumours to HDAC inhibitors via suppressing JAK1-STAT3-BCL2 signalling.

Despite initial progress in preclinical models, most known histone deacetylase inhibitors (HDACis) used as a single agent have failed to show clinical benefits in nearly all types of solid tumours. Hence, the efficacy of HDACis in solid tumours remains uncertain. Herein, we developed a hybrid HDAC inhibitor that sensitized solid tumours to HDAC-targeted treatment.

Statins and Multiple Noncardiovascular Outcomes: Umbrella Review of Meta-analyses of Observational Studies and Randomized Controlled Trials.

Background: Many effects of statins on non-cardiovascular disease (non-CVD) outcomes have been reported.

Purpose: To evaluate the quantity, validity, and credibility of evidence regarding associations between statins and non-CVD outcomes and the effects of statins on these outcomes.

Data Sources: MEDLINE and EMBASE (English terms only, inception to 28 May 2018).

Maintaining "mianzi" and "lizi": Understanding the reasons for formality marriages between gay men and lesbians in China.

As a result of societal expectations and to avoid societal homophobia, many lesbians and gay men in China marry heterosexual partners and do not disclose their own sexual orientation. This study used qualitative methods to explore why gay men enter into such marriages of convenience. A total of 17 in-depth interviews were conducted with lesbians and gay men who had entered "formality marriages.

Spontaneous expulsion of a huge cervical leiomyoma from the vagina after cesarean: A case report with literature review.

Rationale: As more and more women delay their child bearing age, the prevalence of uterine fibroids during pregnancy is likely to increase.

Patient Concerns & Lessons: We report a Chinese Tibetan case with spontaneous expulsion of a huge cervical myoma after cesarean. Decreased blood supply of the myoma and the uterine contraction may contribute to the spontaneous expulsion.

High-Throughput Sequencing of the Expressed Torafugu () Antibody Sequences Distinguishes IgM and IgT Repertoires and Reveals Evidence of Convergent Evolution.

B-cell antigen receptor (BCR) or antibody diversity arises from somatic recombination of immunoglobulin (Ig) gene segments and is concentrated within the Ig heavy (H) chain complementarity-determining region 3 (CDR-H3). We performed high-throughput sequencing of the expressed antibody heavy-chain repertoire from adult torafugu. We found that torafugu use between 70 and 82% of all possible V (variable), D (diversity), and J (joining) gene segment combinations and that they share a similar frequency distribution of these VDJ combinations.

Noninvasive detection of fetal subchromosomal abnormalities by semiconductor sequencing of maternal plasma DNA.

Noninvasive prenatal testing (NIPT) using sequencing of fetal cell-free DNA from maternal plasma has enabled accurate prenatal diagnosis of aneuploidy and become increasingly accepted in clinical practice. We investigated whether NIPT using semiconductor sequencing platform (SSP) could reliably detect subchromosomal deletions/duplications in women carrying high-risk fetuses. We first showed that increasing concentration of abnormal DNA and sequencing depth improved detection.

Insight into the efficient transfection activity of a designed low aggregated magnetic polyethyleneimine/DNA complex in serum-containing medium and the application in vivo.

A designed low aggregated magnetic polyethyleneimine/DNA (MPD-cc) complex showed efficient transfection in serum-containing medium for PEI-mediated gene transfection in vitro and in vivo, but the mechanism remains unclear. The present study provides an insight into the extracellular and intracellular fates of the magnetic gene complexes, evaluates their transfection efficiency and body distribution after systemic administration assisted by fluorescent imaging technology. The PEI cationic complexes in our study switched to be negatively charged in the serum-containing medium due to protein corona formation, and the complexes displayed negligible aggregation from transmission electron microscopy observation and dynamic light scattering analysis.

Noninvasive prenatal diagnosis of common aneuploidies by semiconductor sequencing.

Massively parallel sequencing (MPS) of cell-free fetal DNA from maternal plasma has revolutionized our ability to perform noninvasive prenatal diagnosis. This approach avoids the risk of fetal loss associated with more invasive diagnostic procedures. The present study developed an effective method for noninvasive prenatal diagnosis of common chromosomal aneuploidies using a benchtop semiconductor sequencing platform (SSP), which relies on the MPS platform but offers advantages over existing noninvasive screening techniques.

Entropic stabilization of nanoscale voids in materials under tension.

While preexisting defects are known to act as nucleation sites for plastic deformation in shocked materials, the kinetics of the early stages of plastic yield are still poorly understood. We use atomistic simulation techniques to investigate the kinetics of plastic yield around small preexisting voids in copper single crystals under uniaxial tensile strain. We demonstrate that at finite temperatures, these voids are stabilized by strong entropic effects that confer them significant lifetimes even when the static mechanical instability limit is exceeded.

Targeting the kynurenine pathway as a potential strategy to prevent and treat Alzheimer's disease.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder of the elderly accounting for the vast majority of dementia. Recently, many studies have implicated the role of inflammatory response, especially neuroinflammatory response in the development and progression of AD. However, the underlying mechanism of how inflammatory response induces AD is unknown.