Classifying tumour infiltrating lymphocytes in oral squamous cell carcinoma histopathology using joint learning framework.

Oral squamous cell carcinoma (OSCC) is the most common form of oral cancer, with increasing global incidence and have poor prognosis. Tumour-infiltrating lymphocytes (TILs) are recognized as a key prognostic indicator and play a vital role in OSCC grading. However, current methods for TILs quantification are based on subjective visual assessments, leading to inter-observer variability and inconsistent diagnostic reproducibility.

Cushing syndrome.

Cushing syndrome (CS) is a constellation of signs and symptoms caused by excessive exposure to exogenous or endogenous glucocorticoid hormones. Endogenous CS is caused by increased cortisol production by one or both adrenal glands (adrenal CS) or by elevated adrenocorticotropic hormone (ACTH) secretion from a pituitary tumour (Cushing disease (CD)) or non-pituitary tumour (ectopic ACTH secretion), which stimulates excessive cortisol production. CS is associated with severe multisystem morbidity, including impaired cardiovascular and metabolic function, infections and neuropsychiatric disorders, which notably reduce quality of life.

Long-term Mental Health Morbidity in Adult Survivors of COVID-19 Critical Illness - A Population-based Cohort Study.

Background: Survivorship after coronavirus disease 2019 (COVID-19) critical illness may be associated with important long-term sequelae, but little is known regarding mental health outcomes.

Research Question: What is the association between COVID-19 critical illness and new post-discharge mental health diagnoses.

Study Design: AND METHODS: We conducted a population-based cohort study in Ontario, Canada (January 1, 2020-March 31, 2022).

Retraction Note: Biserial targeted feature projection based radial kernel regressive deep belief neural learning for covid-19 prediction.

[This retracts the article DOI: 10.1007/s00500-022-06943-x.].

Updates on CAD risk assessment: using the coronary artery calcium score in combination with traditional risk factors.

Background: Coronary artery disease (CAD) is the third leading cause of death worldwide, so prevention and early diagnosis play important roles to reduce mortality and morbidity. Traditional risk-score assessments were used to find the at-risk patients in order to prevent or early treatment of CAD. Adding imaging data to traditional risk-score systems will able us to find these patients more confidently and reduce the probable mismanagements.

Environmental Catalysis for NO Reduction by Manipulating the Dynamic Coordination Environment of Active Sites.

Nowadays, it is challenging to achieve SO-tolerant environmental catalysis for NO reduction because of the thermodynamically favorable transformation of reactive sites to inactive sulfate species in the presence of SO. Herein, we achieve enhanced low-temperature SO-tolerant NO reduction by manipulating the dynamic coordination environment of active sites. Engineered by coordination chemistry, SiO-CeO composite oxides with a short-range ordered Ce-O-Si structure were elaborately constructed on a TiO support.

Comparison of Auditory Perception Scores Following Unilateral Cochlear Implantation in Children From Different Regions Using Neubio's Full-Spectrum Continuous Stimulation.

Aims And Objectives: The study aimed to compare the auditory perception status of children from different socioeconomic backgrounds, specifically urban versus rural. It also examined the correlation between outcome measures and the frequency of auditory verbal therapy sessions attended, as well as the impact of continuous electric analog stimulation on the age of implantation.

Material And Methods: A retrospective cohort study was carried out on 30 children who have received unilateral cochlear implantation in rural versus urban backgrounds.

The Diagnostic Efficacy of Flexible Fiberoptic Laryngoscopy and Its Correlation With Histopathology in Different Benign Lesions of the Vocal Cord in a Tertiary Care Hospital: A Prospective Clinical Study.

Introduction Benign vocal cord lesions are diagnosed by clinical examination with usually an office-based laryngoscopy examination. The severity of voice impairment can be assessed by severity scores such as the Voice Handicap Index (VHI). These lesions are usually treated by conservative methods such as voice rest/restriction and voice therapy.

Zebrafish: A Cost-Effective Model for Enhanced Forensic Toxicology Capabilities in Low- and Middle-Income Countries.

Low- and middle-income countries (LMICs) are increasingly challenged by the rising burden of medicolegal cases. Traditional forensic infrastructure and in vivo rodent models often have significant limitations due to high costs and ethical concerns. As a result, zebrafish () are gaining popularity as an attractive alternative model for LMICs because of their cost-effectiveness and practical advantages.

Opportunistic bone density assessment using pre-treatment [18F]FDG-PET/CT identifies fracture risk in lymphoma patients undergoing corticosteroid-containing chemotherapy.

Not available.

Minimal clinically important difference (MCID), patient-acceptable symptom state (PASS), and substantial clinical benefit (SCB) following surgical knee ligament reconstruction: a systematic review.

Introduction: The minimal clinically important difference (MCID), patient-acceptable symptom state (PASS), and substantial clinical benefit (SCB) are designed to prioritise clinically significant outcomes that demonstrate true clinical benefit rather than relying solely on statistical significance. These instruments aid clinicians in understanding the patient's perspective, allowing healthcare professionals to set treatment goals that align with patients' desires and expectations. This systematic review analysed tools to estimate the clinical relevance of the most commonly used PROMs to assess patients following surgical knee ligament reconstruction.

Double-sided van der Waals epitaxy of topological insulators across an atomically thin membrane.

Atomically thin van der Waals (vdW) films provide a material platform for the epitaxial growth of quantum heterostructures. However, unlike the remote epitaxial growth of three-dimensional bulk crystals, the growth of two-dimensional material heterostructures across atomic layers has been limited due to the weak vdW interaction. Here we report the double-sided epitaxy of vdW layered materials through atomic membranes.

Stalled ribosome rescue factors exert different roles depending on types of antibiotics in Escherichia coli.

Escherichia coli possesses three stalled-ribosome rescue factors, tmRNA·SmpB (primary factor), ArfA (alternative factor to tmRNA·SmpB), and ArfB. Here, we examined the susceptibility of rescue factor-deficient strains from E. coli SE15 to various ribosome-targeting antibiotics.

Cohort profile: the BangladEsh Longitudinal Investigation of Emerging Vascular and nonvascular Events (BELIEVE) cohort study.

Purpose: Bangladesh has experienced a rapid epidemiological transition from communicable to non-communicable diseases (NCDs) in recent decades. There is, however, limited evidence about multidimensional determinants of NCDs in this population. The BangladEsh Longitudinal Investigation of Emerging Vascular and nonvascular Events (BELIEVE) study is a household-based prospective cohort study established to investigate biological, behavioural, environmental and broader determinants of NCDs.

Greening but enhanced vegetation water stress in the Yellow River Basin: A holistic perspective.

The Yellow River Basin (YRB) has emerged as a focal point of global vegetation greening due to climate change and human activities. Given its ecological vulnerability and intense human activities, environmental sustainability has become an urgent concern for scholars. Current research on the hydrological effects of vegetation greening, from a reductionist perspective, still struggle to answer the crucial question that whether vegetation water stress is increasing or decreasing.

Image quality assessment and white matter hyperintensity quantification in two accelerated high-resolution 3D FLAIR techniques: Wave-CAIPI and deep learning-based SPACE.

Aim: To compare the image quality obtained using two accelerated high-resolution 3D fluid-attenuated inversion recovery (FLAIR) techniques for the brain-deep learning-reconstruction SPACE (DL-SPACE) and Wave-CAIPI FLAIR.

Materials And Methods: A total of 123 participants who underwent DL-SPACE and Wave-CAIPI FLAIR brain imaging were retrospectively reviewed. In a qualitative analysis, two radiologists rated the quality of each image, including the overall image quality, artifacts, sharpness, fine-structure conspicuity, and lesion conspicuity based on Likert scales.

Prognostic Value of POST-Treatment Extent of Tumor (POSTTEXT) System in Patients with Hepatoblastoma.

Purpose: To assess prognostic values of the POST-Treatment Extent of Tumor (POSTTEXT) system and clinical factors after neoadjuvant chemotherapy in hepatoblastoma patients and evaluate benefits of posttreatment imaging and clinical factors concomitant with Children's Hepatic Tumors International Collaboration-Hepatoblastoma Stratification (CHIC-HS) system.

Materials And Methods: This single-center retrospective study of hepatoblastoma cases (2006-2022) included pediatric patients receiving ≥ 4 cycles of neoadjuvant chemotherapy, with pre- and post-treatment imaging and complete medical records. Clinical data included age, sex, and serum alpha-fetoprotein (AFP) levels.

Life satisfaction around the world: Measurement invariance of the Satisfaction With Life Scale (SWLS) across 65 nations, 40 languages, gender identities, and age groups.

The Satisfaction With Life Scale (SWLS) is a widely used self-report measure of subjective well-being, but studies of its measurement invariance across a large number of nations remain limited. Here, we utilised the Body Image in Nature (BINS) dataset-with data collected between 2020 and 2022 -to assess measurement invariance of the SWLS across 65 nations, 40 languages, gender identities, and age groups (N = 56,968). All participants completed the SWLS under largely uniform conditions.

LI-RADS Ultrasound Surveillance Version 2024: Comparison With Version 2017 for Hepatocellular Carcinoma Detection and Risk Factors for Visualization Score C.

The LI-RADS Ultrasound Surveillance algorithm was updated in 2024, incorporating alpha-fetoprotein (AFP) and visualization score of VIS-C into management recommendations after nonpositive results. This study aimed to compare the diagnostic performance of LI-RADS Ultrasound Surveillance version 2017 (v2017) and version 2024 (v2024) for hepatocellular carcinoma (HCC) detection in at-risk patients and to identify predictors of VIS-C on follow-up surveillance examinations. This retrospective analysis included 407 patients (median age, 56 years; 230 male, 177 female) with cirrhosis who underwent rounds of semi-annual surveillance ultrasound as part of a prospective trial from November 2011 to December 2012.

Immunogenicity of the 9-valent human papillomavirus vaccine: Post hoc analysis from five phase 3 studies.

Post hoc analyses of 9-valent human papillomavirus (9vHPV) vaccine immunogenicity were conducted in five Phase 3 studies that enrolled males. Month 7 antibody geometric mean titers (GMTs) after three 9vHPV vaccine doses were analyzed in 10,024 males/females aged 16-26 years from studies 001 (NCT00543543), 002 (NCT00943722), 003 (NCT01651949), and 020 (NCT02114385). Covariates considered were age, gender, sexual orientation, region of residence, and race.

Evaluation of Perceptual and Anthropometrical Facial Changes According to Increase in Vertical Dimension of Occlusion.

Background: For restorative demands, increased vertical dimension of occlusion (VDO) is sometimes necessary, as facial changes can be perceptible.

Objectives: This study aimed to evaluate the perception of facial change due to increased VDO and associated soft tissue changes using 3D-scanned facial images.

Methods: Forty participants with healthy dentition and no loss of VDO were recruited.

Confronting allergies: strategies for combating pollution and safeguarding our health.

Increasing evidence demonstrates a robust link between environmental pollutants and allergic reactions, with air and indoor pollution exacerbating respiratory allergies and climate change intensifying seasonal allergies. Comprehensive action, including government regulations, public awareness, and individual efforts, is essential to mitigate pollution's impact on allergies and safeguard public health and ecological balance. Recent findings indicate a strong correlation between environmental pollutants and allergic reactions, with air pollution from vehicular emissions and industrial activities exacerbating respiratory allergies like asthma and allergic rhinitis.

Application of Animal Resources into the Maillard Reaction Model System to Improve Meat Flavor.

Simulating meat flavor via Maillard reaction model systems that contain a mixture of amino acids and reducing sugars is an effective approach to understanding the reaction mechanism of the flavor precursors. Notably, animal resources such as fish, beef, chicken, pork hydrolysates, and fats are excellent precursors in promoting favorable meaty and roasted flavors and umami tastes of Maillard reaction products. The experimental conditions and related factors of the model systems for sensory enhancements, debittering, and off-flavor reduction with meat and by-products are summarized in this review.

Hands at work: A randomised cross-over mannequin-based trial exploring the impact of hand preference of health care professionals on effectiveness of chest compressions.

Aim And Background: There are various theories regarding the ideal hand to be in contact with chest during chest compressions when healthcare professionals and medical students perform cardiopulmonary resuscitation (CPR). Our study aimed to compare the impact of preferred versus non-preferred hand placement on chest on the CPR quality.

Methodology: The volunteers were randomised to place their preferred (P)/non-preferred (NP) hand over sternum for the first session and switch hands for the second.