8 results match your criteria: "and Rammelkamp Center for Research[Affiliation]"

Integrins are heterodimeric receptors that regulate cell adhesion, migration, and apoptosis. Integrin αvβ8 is most abundantly expressed in kidney and brain, and its major ligand is latent transforming growth factor-β (TGF-β). Kidney αvβ8 localizes to mesangial cells, which appose glomerular endothelial cells and maintain glomerular capillary structure by mechanical and poorly understood paracrine mechanisms.

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Collagen XVIII is characterized by three variant N termini, an interrupted collagenous domain, and a C-terminal antiangiogenic domain known as endostatin. We studied here the roles of this collagen type and its variant isoforms in the mouse kidney. Collagen XVIII appeared to be in a polarized orientation in the tubular basement membranes (BMs), the endostatin domain embedded in the BM, and the N terminus residing at the BM-fibrillar matrix interface.

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Novel Ca receptor signaling pathways for control of renal ion transport.

Curr Opin Nephrol Hypertens

January 2010

Departments of Medicine and Physiology, Case-Western Reserve University, Louis Stokes VAMC and Rammelkamp Center for Research, Metrohealth Medical Center, Cleveland, Ohio, USA.

Purpose Of Review: A rise in extracellular Ca acting through the calcium sensing receptor (CaR) causes physiologically significant loss of Na, K, Cl, Ca, and water. The CaR is expressed in all nephron segments, but its effects on ion and water transport in specific segments as well as the mechanisms by which it regulates ion and water transport is not fully understood. This review will summarize recent information regarding the renal transport effects of the CaR.

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Glomerular podocyte differentiation state is critical for filtration barrier function and is regulated by WT1, a zinc finger transcription factor. A yeast two-hybrid assay identified a novel, WT1-interacting protein (WTIP) that maps to human chromosome 19q13.1, a region with genes linked to familial focal segmental glomerulosclerosis.

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Kidney disease, genotype and the pathogenesis of vasculopathy.

Curr Opin Nephrol Hypertens

January 2003

Department of Medicine, School of Medicine, Case Western Reserve University, and Rammelkamp Center for Research and Education, MetroHealth Medical Center, Cleveland, Ohio 44109-1998, USA.

Purpose Of Review: The two leading causes of end-stage renal disease in the United States are diabetes mellitus and hypertensive nephrosclerosis, accounting for over two-thirds of all cases. In many patients both diseases are associated with small- and large-vessel disease, commonly attributed to hypertension or accelerated atherosclerosis. Recent investigations, however, have suggested that renal large-vessel and microvascular disease may be independent contributors to progressive kidney failure.

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Approaches to understanding susceptibility to nephropathy: from genetics to genomics.

Kidney Int

January 2002

Department of Epidemiology and Biostatistics, Case Western Reserve University, and Rammelkamp Center for Research and Education, MetroHealth Medical Center, Cleveland, Ohio 44109-4945, USA.

The incidence of end-stage renal disease (ESRD) is increasing worldwide despite efforts to slow the progression of chronic renal failure (CRF) by controlling blood pressure and hyperglycemia. Two available therapies for ESRD, dialysis and transplantation, are expensive and are at best palliative. Recently, data from several laboratories have demonstrated that ESRD is under substantial genetic control, and efforts to identify these genetic determinants are underway.

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Apoptosis and JNK activation are differentially regulated by Fas expression level in renal tubular epithelial cells.

Kidney Int

July 2001

Department of Medicine, Case Western Reserve University School of Medicine, and Rammelkamp Center for Research, MetroHealth Medical Center, Cleveland, Ohio, USA.

Background: In chronic renal disease, renal tubular epithelial cell (RTC) Fas expression is up-regulated, leading to apoptotic RTC deletion and tubular atrophy. In vitro, cytokine- or hypoxia-induced up-regulation of Fas expression is associated with RTC apoptosis. In contrast, constitutively expressed, low level RTC Fas does not mediate apoptosis, suggesting that Fas may be coupled to expression level-dependent RTC signaling pathways.

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Semantics, inflammation, cytokines and common sense.

Cytokine Growth Factor Rev

June 1999

Case Western Reserve University, Department of Medicine, and Rammelkamp Center for Research, MetroHealth Campus, Cleveland, OH 44109-1998, USA.

Semantic evaluation of some of the terms we regularly employ--inflammation, anti-inflammatory, pro-inflammatory, anti-inflammatory drugs, cytokines, homeostasis and stress--raises concerns about their precise meanings and about their mechanistic implications. Semantic imprecision may have undesirable conceptual consequences.

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