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Benefits and Harms of Standard Versus Reduced-Dose Direct Oral Anticoagulant Therapy for Older Adults With Multiple Morbidities and Atrial Fibrillation.
J Am Heart Assoc
November 2023
Department of Health Services, Policy, and Practice Brown University School of Public Health Providence RI.
Article Synopsis
- A study analyzed the use of direct oral anticoagulants (DOACs) in older adults (≥65 years) with nonvalvular atrial fibrillation living in nursing homes, finding that 48% received reduced doses.
- The study showed that standard dosing was linked to a higher rate of major bleeding compared to reduced doses, particularly in those over 80 years old and with lower body mass indexes.
- However, there was no significant difference in all-cause mortality or thrombotic events between standard and reduced dosing, suggesting that reduced-dose DOACs may be safer for many older adults with multiple health issues.