2 results match your criteria: "and Pharmacology Department of Pharmacy College of Harbin Medical University[Affiliation]"
CircRNA CDR1AS promotes cardiac ischemia-reperfusion injury in mice by triggering cardiomyocyte autosis.
J Mol Med (Berl)
January 2025
Cardiovascular Surgery Department of The First Affiliated Hospital of Harbin Medical University, and Pharmacology Department of Pharmacy College of Harbin Medical University, Harbin, 150081, China.
Myocardial ischemia/reperfusion (IR) injury is a common adverse event in the clinical treatment of myocardial ischemic disease. Autosis is a form of cell death that occurs when autophagy is excessive in cells, and it has been associated with cardiac IR damage. This study aimed to investigate the regulatory mechanism of circRNA CDR1AS on autosis in cardiomyocytes under IR.
View Article and Find Full Text PDFMSCs biomimetic ultrasonic phase change nanoparticles promotes cardiac functional recovery after acute myocardial infarction.
Biomaterials
February 2025
Department of Cardiology, University of Nebraska Medical Center, Omaha, NE, NE 68198, USA.
Article Synopsis
- Rising cases of Acute Myocardial Infarction (AMI) in younger individuals raise public health concerns, as standard treatments often fail to repair the heart's microvasculature, increasing heart failure risk.
- Mesenchymal Stromal Cells (MSCs) transplantation shows promise in improving cardiac function post-AMI, but their effectiveness is limited by the harsh environment following the event.
- The study introduces innovative ultrasound-responsive nanoparticles that integrate MSC proteins and microRNA-125b to enhance targeted delivery during AMI therapy, aiming to improve recovery and cardiac function.