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Antipsychotics possessing antidepressive efficacy increase Golf protein in rat striatum.
Psychopharmacology (Berl)
December 2008
Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, and Okayama Red Cross General Hospital, 2-5-1 Shikata-cho, Okayama, 700-8558, Japan.
Introduction: Recently, second-generation antipsychotics (SGAs) have been widely used in the treatment of mood disorders. However, the mechanisms of the antidepressant effect of SGAs remain unclear. We proposed that Golf protein, a stimulant alpha-subunit of G protein coupled with the dopamine D1 receptor, might a play the key role in the antidepressive effect of antidepressants.
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