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Neutrophil gelatinase-associated lipocalin: a novel marker of contrast nephropathy risk.
Am J Nephrol
November 2012
Section of Cardiology, Department of Medicine, Providence Hospital and Medical Center, St. John Providence Health System, Southfield, William Beaumont Hospital, Royal Oak, and Northern Michigan Hospital, Petoskey, MI 48374, USA.
Background: Neutrophil gelatinase-associated lipocalin (NGAL, siderocalin) is a protein secreted by the kidney in the setting of acute kidney injury in an attempt to regulate and bind the release of catalytic iron from injured cells. We sought to evaluate the relationships between baseline NGAL, renal filtration function, and the degree of injury reflected by further increases in NGAL.
Methods: This study was a prospective, blinded assessment of blood samples taken from patients with estimated glomerular filtration rate (eGFR) <75 ml/min/1.