1 results match your criteria: "and Neuroscience and Cell Biology University of Texas Medical Branch Galveston Texas.[Affiliation]"
Tau oligomers in cerebrospinal fluid in Alzheimer's disease.
Ann Clin Transl Neurol
April 2017
Mitchell Center for Neurodegenerative Diseases University of Texas Medical Branch Galveston Texas; Department of Neurology, and Neuroscience and Cell Biology University of Texas Medical Branch Galveston Texas.
Objective: With an increasing incidence of Alzheimer's disease (AD) and neurodegenerative tauopathies, there is an urgent need to develop reliable biomarkers for the diagnosis and monitoring of the disease, such as the recently discovered toxic tau oligomers. Here, we aimed to demonstrate the presence of tau oligomers in the cerebrospinal fluid (CSF) of patients with cognitive deficits, and to determine whether tau oligomers could serve as a potential biomarker for AD.
Methods: A multicentric collaborative study involving a double-blinded analysis with a total of 98 subjects with moderate to severe AD ( = 41), mild AD ( = 31), and nondemented control subjects ( = 26), and two pilot studies of 33 total patients with AD ( = 19) and control ( = 14) subjects were performed.