32 results match your criteria: "and National and Kapodistrian University of Athens[Affiliation]"

Rehabilitation Is Associated With Improvements in Post-COVID-19 Sequelae.

Respir Care

October 2024

1st Department of Critical Care and Pulmonary Services, Evangelismos General Hospital, Athens, Greece; and National and Kapodistrian University of Athens, School of Medicine, Athens, Greece.

Article Synopsis
  • Post-COVID-19 syndrome affects millions, and while rehabilitation is important, studies show mixed results due to variations in participant characteristics and factors like age and disease severity that are not well understood.
  • This non-randomized case-control study involved participants with post-COVID-19 symptoms, comparing those who attended an 8-week supervised rehabilitation program to those who did not, with measurements taken at the start and after the program.
  • Results indicated that participants in rehabilitation showed significant improvements in various health metrics, including walking distance, physical performance, quality of life, and cognitive function, further highlighting the potential benefits of rehabilitation for post-COVID-19 recovery.
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Heart failure (HF) is a well-described final common pathway for a broad range of diseases however substantial confusion exists regarding how to describe, study, and track these underlying etiologic conditions. We describe (1) the overlap in HF etiologies, comorbidities, and case definitions as currently used in HF registries led or managed by members of the global HF roundtable; (2) strategies to improve the quality of evidence on etiologies and modifiable risk factors of HF in registries; and (3) opportunities to use clinical HF registries as a platform for public health surveillance, implementation research, and randomized registry trials to reduce the global burden of noncommunicable diseases. Investment and collaboration among countries to improve the quality of evidence in global HF registries could contribute to achieving global health targets to reduce noncommunicable diseases and overall improvements in population health.

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Introduction: Clinical disadvantages of initiating ART at low CD4 counts have been clearly demonstrated but whether any excess risk remains even after reaching relatively high/safe CD4 levels remains unclear. We explore whether individuals starting ART with <500 CD4 cells/μL who increased their CD4 count above this level, have, from this point onwards, similar risk of clinical progression to serious AIDS/non-AIDS events or death with individuals starting ART with ≥500 CD4 cells/μL.

Methods: Data were derived from a multicenter cohort (AMACS).

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Objectives: Acute bacterial skin and skin-structure infections (ABSSSIs) are a common source of morbidity in both the community and hospital settings. The current standard of care (SoC) requires multiple-dose intravenous (IV) regimens, which are associated with high hospitalisation rates, concomitant event risks and costs. Dalbavancin is a lipoglycopeptide, long-acting antibiotic that is effective against Gram-positive microorganisms, including methicillin-resistant Staphylococcus aureus (MRSA).

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Recent research on antiretroviral treatment (ART) for HIV suggests that integrase strand transfer inhibitors (INSTIs) cause faster weight gain compared to other drug classes. Here, we investigated changes in body mass index (BMI) and obesity prevalence after treatment initiation and corresponding differences between drug classes. Data were derived from a large collaborative cohort in Greece.

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Background: Valosin-containing protein (VCP) disease, caused by mutations in the gene, results in myopathy, Paget's disease of bone (PBD) and frontotemporal dementia (FTD). Natural history and genotype-phenotype correlation data are limited. This study characterises patients with mutations in gene and investigates genotype-phenotype correlations.

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Background And Objectives: IVIg has been the preferred immunotherapy in stiff-person syndrome (SPS) based on a 3-month controlled trial, but whether it is also effective in inducing long-term benefits or arresting disease progression is unknown. The information is needed because SPS is a progressively disabling disease and IVIg is liberally used as chronic therapy without efficacy data. The present study explores the long-term effects of IVIg in the largest cohort of well-characterized patients with SPS followed by the same clinicians over 10 years.

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Longitudinal Trajectory of the Link Between Ventral Striatum and Depression in Adolescence.

Am J Psychiatry

July 2022

Department of Psychiatry, Laboratório Interdisciplinar de Neurociências Clínicas, Universidade Federal de São Paulo, São Paulo, Brazil (Pan, Sato); National Institute of Developmental Psychiatry for Children and Adolescents, São Paulo, Brazil (Pan, Sato); Section on Neurobiology of Fear and Anxiety, NIMH, Bethesda, Md. (Pan, Westwater, Grillon, Ernst); Mathematics and Statistics Institute, Universidade Federal do ABC, Santo André, Brazil (Sato); Institut National de la Santé et de la Recherche Médicale, INSERM U 1299 "Trajectoires développementales en psychiatrie," Ecole Normale Supérieure Paris-Saclay, Université Paris-Saclay, Université Paris Cité, CNRS, Centre Borelli, Gif-sur-Yvette, France (Paillère Martinot, Martinot, Artiges); AP-HP Sorbonne Université, Department of Child and Adolescent Psychiatry, Pitié-Salpêtrière Hospital, Paris (Paillère Martinot); Department of Psychiatry, EPS Barthélemy Durand, Etampes, France (Artiges); Department of Social and Health Care, Psychosocial Services Adolescent Outpatient Clinic Kauppakatu 14, Lahti, Finland (Penttilä); Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany (Grimmer, Banaschewski); MSB Medical School Berlin, Department of Psychology and Psychotherapy, Berlin (van Noort); Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Center, Göttingen, Germany (Becker); Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin (Bokde); Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology, and Neuroscience, SGDP Centre, King's College London (Desrivières, Poustka); Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, and Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, Germany (Flor); Departments of Psychiatry and Psychology, University of Vermont, Burlington (Garavan); Physikalisch-Technische Bundesanstalt, Braunschweig and Berlin, Germany (Ittermann); Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig-Holstein, Kiel University, Kiel, Germany (Nees); NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, France (Papadopoulos Orfanos); Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany (Fröhner); School of Psychology and Global Brain Health Institute, Trinity College Dublin (Whelan); Center for Population Neuroscience and Stratified Medicine (PONS), ISTBI, Fudan University Shanghai, and Charité Mental Health, Berlin (Schumann); Department of Psychiatry, University of Cambridge, Herchel Smith Building, Addenbrooke's Hospital, Cambridge, U.K. (Westwater); Department of Education, ICT, and Learning, Østfold University College, Halden, Norway (Cogo-Moreira); Division of Psychiatry, University College London, and National and Kapodistrian University of Athens, Athens (Stringaris).

Objective: Research in adolescent depression has found aberrant intrinsic functional connectivity (iFC) among the ventral striatum (VS) and several brain regions implicated in reward processing. The present study probes this question by taking advantage of the availability of data from a large youth cohort, the IMAGEN Consortium.

Methods: iFC data from 303 adolescents (48% of them female) were used to examine associations of VS connectivity at baseline (at age 14) with depressive disorders at baseline and at 2-year (N=250) and 4-year (N=219) follow-ups.

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Peripheral Neuropathy Evaluations of Patients With Prolonged Long COVID.

Neurol Neuroimmunol Neuroinflamm

May 2022

From the Nerve Unit (A.L.O., A.J.M.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston; Department of Pathology (Neuropathology) (A.L.O.), Massachusetts General Hospital, Boston, Massachusetts; Department of Neurology (M.K.), Dell Medical School, The University of Texas, Austin, Texas; Department of Neurology (L.S.T.), Confluence Health, Wenatchee; Section of Infections of the Nervous System (B.S., A.N.), National Institute of Neurological Disorders and Stroke (NINDS) at the National Institutes of Health (NIH), Bethesda, Maryland; and Neuromuscular Division (M.C.D.), Department of Neurology, Thomas Jefferson University, Philadelphia, Pennsylvania, and National and Kapodistrian University of Athens Medical School, Greece.

Background And Objectives: Recovery from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection appears exponential, leaving a tail of patients reporting various long COVID symptoms including unexplained fatigue/exertional intolerance and dysautonomic and sensory concerns. Indirect evidence links long COVID to incident polyneuropathy affecting the small-fiber (sensory/autonomic) axons.

Methods: We analyzed cross-sectional and longitudinal data from patients with World Health Organization (WHO)-defined long COVID without prior neuropathy history or risks who were referred for peripheral neuropathy evaluations.

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Article Synopsis
  • A phase-II study evaluated the effectiveness and safety of atezolizumab combined with obinutuzumab in relapsed/refractory mantle cell lymphoma (MCL) and Waldenström's macroglobulinemia (WM), and with rituximab in marginal zone lymphoma (MZL).
  • Objective response rates were 16.7% for MCL, 42.9% for MZL, and no responses for WM, with median response durations of 6.8 months for MCL and not reached for MZL.
  • Treatment-emergent adverse events (TEAEs) were common across patient groups (93.3% in MCL, 95.2% in MZ
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Edoxaban versus Vitamin K Antagonist for Atrial Fibrillation after TAVR.

N Engl J Med

December 2021

From the Department of Cardiology, Erasmus University Medical Center, Thoraxcenter, Rotterdam, the Netherlands (N.M.V.M., E.B.); Daiichi Sankyo, Basking Ridge, NJ (M.U., J.J., A.D., C.C.); the Department of Internal Medicine II, Division of Cardiology, Vienna General Hospital, Medical University, Vienna (C.H., I.L.); the Department of Internal Medicine, St. Johannes Hospital, Dortmund (H.M.), the Department of Internal Medicine I, University Hospital Würzburg, Würzburg (P.N.), the Department of Internal Medicine-Cardiology, Heart Center Leipzig at University of Leipzig, Leipzig (H.T.), Bremer Institute for Heart and Circulation Research at Klinikum Links der Weser, Bremen (R.H.), the Department of Cardiology, Asklepios Klinik St. Georg, Hamburg (F.M.), Daiichi Sankyo Europe, Munich (P.L., H.L.), the Department of Neurology, Alfried Krupp Krankenhaus, Essen (R.V.), and the Department of Neurology, University Hospital Heidelberg, Heidelberg (R.V.) - all in Germany; Zena and Michael A. Wiener Cardiovascular Institute, Mount Sinai Hospital, New York (R. Mehran, G.D.D.); the Department of Cardiology, Centro de Investigación Biomédica en Red Enfermedades Cardiovasculares, Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela (D.L.-O.), the Cardiovascular Institute, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (L.N.-F.), the Department of Cardiology, University Hospital La Paz (R. Moreno), and the Department of Cardiology, University Hospital Ramon y Cajal (J.L.Z.), Madrid - all in Spain; the Department of Cardiology, Washington Adventist Hospital, Takoma Park, MD (F.S.); the Department of Cardiology, Toyohashi Heart Center, Toyohashi (M.Y.), the Department of Cardiology, Teikyo University School of Medicine (Y.W.), and the Department of Cardiology, Keio University School of Medicine (K.H.), Tokyo, and the Division of Cardiology and Catheterization Laboratories, Shonan Kamakura General Hospital, Kamakura (S.S.) - all in Japan; the Department of Cardiology, Jessa Hospital, Hasselt, Belgium (P.V.); Quebec Heart and Lung Institute, Laval University, Quebec, QC, Canada (J.R.-C.); the Division of Cardiovascular Medicine, University Hospital of Strasbourg, Strasbourg, France (P.O.); the Division of Cardiology, Policlinico Hospital, University of Catania, Catania, Italy (P.C.); the Department of Internal Medicine, Cardiovascular Center, Seoul National University Hospital, Seoul, South Korea (H.-S.K.); the Department of Cardiology, University of Bern, Bern (T.P.), and Cardiocentro Ticino Institute and Department of Biomedical Sciences, University of Italian Switzerland, Lugano (M.V.) - both in Switzerland; the Department of Cardiology, University Hospital of Wales, Cardiff (R.A.), and the Division of Brain Sciences, Imperial College London, London (R.V.) - both in the United Kingdom; the Cardiology Section, University of Oklahoma Health Sciences Center, Oklahoma City (U.B.); and National and Kapodistrian University of Athens, School of Medicine, Athens (G.D.D.).

Background: The role of direct oral anticoagulants as compared with vitamin K antagonists for atrial fibrillation after successful transcatheter aortic-valve replacement (TAVR) has not been well studied.

Methods: We conducted a multicenter, prospective, randomized, open-label, adjudicator-masked trial comparing edoxaban with vitamin K antagonists in patients with prevalent or incident atrial fibrillation as the indication for oral anticoagulation after successful TAVR. The primary efficacy outcome was a composite of adverse events consisting of death from any cause, myocardial infarction, ischemic stroke, systemic thromboembolism, valve thrombosis, or major bleeding.

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Concomitant Laparoscopic Splenectomy and Cholecystectomy: A Systematic Review of the Literature.

J Laparoendosc Adv Surg Tech A

July 2020

Second Propaedeutic Department of Surgery, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece.

Concomitant laparoscopic splenectomy and cholecystectomy (CLSC) is performed for concurrent pathologies of the spleen and gallbladder. This systematic review aimed to evaluate the available evidence on its indications, operative technique, and outcomes. The PubMed and Cochrane bibliographical databases were searched from the beginning of time (last search: December 6, 2019) for studies reporting on CLSC.

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Cardiac Imaging in Liver Transplantation Candidates: Current Knowledge and Future Perspectives.

J Clin Med

December 2019

Department of Cardiology, National and Kapodistrian University of Athens Medical School, Hippokration General Hospital, 115 27 Athens, Greece.

Cardiovascular dysfunction in cirrhotic patients is a recognized clinical entity commonly referred to as cirrhotic cardiomyopathy. Systematic inflammation, autonomic dysfunction, and activation of vasodilatory factors lead to hyperdynamic circulation with high cardiac output and low peripheral vascular resistance. Counter acting mechanisms as well as direct effects on cardiac cells led to systolic or diastolic dysfunction and electromechanical abnormalities, which are usually masked at rest but exposed at stress situations.

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The pivotal role of cardiovascular imaging in the identification and risk stratification of non-compaction cardiomyopathy patients.

Heart Fail Rev

November 2020

Mid-German Heart Center, Department of Internal Medicine III (KIM-III), Division of Cardiology, Angiology and Intensive Medical Care, University Hospital Halle, Martin-Luther-University Halle-Wittenberg, Ernst-Grube-Strasse 40, 06120, Halle (Saale), Germany.

Non-compaction cardiomyopathy (NCM) is a heterogeneous myocardial disease that can finally lead to heart failure, arrhythmias, and/or embolic events. Therefore, early diagnosis and treatment is of paramount importance. Furthermore, genetic assessment and counseling are crucial for individual risk assessment and family planning.

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Long-term evolution of CD4+ cell count in patients under combined antiretroviral therapy.

AIDS

August 2019

Department of Hygiene, Epidemiology and Medical Statistics, National and Kapodistrian University of Athens, Medical School.

Objective: Combined antiretroviral treatment (cART) results in profound immunologic improvement, but it is unclear whether CD4 cell counts return to levels similar to those of HIV-negative individuals. We explore long-term CD4 cell count evolution post-cART and its association with baseline levels, virologic suppression, pre-cART cumulative viremia and other factors.

Design: Data were derived from the AMACS.

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To assess the prognostic and predictive value of selected biomarkers involved in cell-cycle regulation or proliferation in patients with HER2-positive early breast cancer. Protein expression of TOP2A, Ki67, cyclin D1, and p27 was immunohistochemically determined in tissue microarrays of surgical specimens from 862 patients randomized to trastuzumab (1 or 2 years; = 561) and observation ( = 301) arms of the HERA trial. The primary analysis endpoint was disease-free survival (DFS).

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CHYLOUS ASCITES AFTER LAPAROSCOPIC LOW ANTERIOR COLORECTAL RESECTION FOR RECTOSIGMOID CARCINOMA: A CASE REPORT AND A LITERATURE REVIEW.

Gastroenterol Nurs

October 2018

Dimitris P. Korkolis, PhD, MD, is Consultant Surgeon, Hellenic Anticancer Institute, "Saint Savvas" Hospital, Athens, Greece. Maria Kapritsou, PhD, RN, Hellenic Anticancer Institute, "Saint Savvas" Hospital, Athens, Greece; and National and Kapodistrian University of Athens, Athens, Greece. Ioannis Passas, MD, is Clinical Research Fellow, Hellenic Anticancer Institute, "Saint Savvas" Hospital, Athens, Greece. Maria Kalafati, PhD, RN, is Laboratory Teaching Staff, Papadiamantopoulou 123, Faculty of Nursing, National and Kapodistrian University of Athens, Athens, Greece. Theodoros Katsoulas, PhD, RN, is Assistant Professor, National and Kapodistrian University of Athens, Faculty of Nursing, Athens, Greece. Evangelos A. Konstantinou, PhD, RN, is Associate Professor of Nursing Anesthesiology, Papadiamantopoulou 123, Faculty of Nursing, National and Kapodistrian University of Athens, Athens, Greece.

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Objective: Aberrant activation of synovial fibroblasts is a key determinant in the pathogenesis of rheumatoid arthritis (RA). The aims of this study were to produce a map of gene expression and epigenetic changes occurring in this cell type during disease progression in the human tumor necrosis factor (TNF)-transgenic model of arthritis and to identify commonalities with human synovial fibroblasts.

Methods: We used deep sequencing to probe the transcriptome, the methylome, and the chromatin landscape of cultured mouse arthritogenic synovial fibroblasts at 3 stages of disease, as well as synovial fibroblasts stimulated with human TNF.

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Endoscopic ultrasound (EUS) is considered a valuable diagnostic tool during the workup of malignant gastric lesions, including primary gastric lymphomas (PGL). Although endoscopy combined with multiple biopsies remains essential in the establishment of PGL diagnosis, EUS utilization in locoregional disease staging has been well documented in the literature. Data also support the possible role of EUS in prediction of response to first-line treatment, that is, eradication.

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Introduction: Docetaxel and erlotinib are registered second-line treatments for wild-type EGFR NSCLC. Previous studies suggested a predictive value of the VeriStrat test in second-line therapy of NSCLC, classifying patients as either VeriStrat good or VeriStrat poor. EMPHASIS-lung aimed at exploring this predictive effect in patients with squamous cell NSCLC.

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Objective: Increased expression of type I interferon (IFN) and a broad signature of type I IFN-induced gene transcripts are observed in patients with systemic lupus erythematosus (SLE) and other systemic autoimmune diseases. To identify disease-relevant triggers of the type I IFN pathway, this study sought to investigate whether endogenous virus-like genomic repeat elements, normally silent, are expressed in patients with systemic autoimmune disease, and whether these retroelements could activate an innate immune response and induce type I IFN.

Methods: Expression of type I IFN and long interspersed nuclear element 1 (LINE-1; L1) was studied by polymerase chain reaction, Western blotting, and immunohistochemistry in samples of kidney tissue from patients with lupus nephritis and minor salivary gland (MSG) tissue from patients with primary Sjögren's syndrome (SS).

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