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Blocking FGF23 signaling improves the growth plate of mice with X-linked hypophosphatemia.
J Endocrinol
September 2023
Institute of Physiology, University of Zurich, and National Center of Competence in Research NNCR Kidney, Zurich, CH, Switzerland.
Fibroblast growth factor 23 (FGF23) is a phosphaturic hormone. X-linked hypophosphatemia (XLH) is the most prevalent inherited phosphate wasting disorder due to mutations in the PHEX gene, which cause elevated circulating FGF23 levels. Clinically, it is characterized by growth impairment and defective mineralization of bones and teeth.
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