Ready reference to common segmental aneusomies by syndromic names, major features and chromosomal locations.

Abnormal gene dosage usually results in recognizable phenotypic abnormalities, especially if it involves a series of contiguous genes. Schmickel (1986) defined contiguous gene syndromes as diseases resulting from loss or gain of a series of adjacent genes. The terms microdeletion and microduplication as well as segmental aneusomy have also been used to describe such losses or gains that may not be readily detectable by Gbanded analysis.

Radiation therapy for symptomatic hepatomegaly in myelofibrosis with myeloid metaplasia.

Objective: To describe the experience with liver irradiation in advanced cases of myelofibrosis with myeloid metaplasia (MMM).

Methods: Over a 20-yr period, 14 patients with MMM were treated with a total of 25 courses of liver, abdominal, or abdominal and pelvic irradiation for symptomatic hepatomegaly with (5 patients) or without (9 patients) ascites. All 14 patients had advanced disease and 11 (79%) had previous splenectomy.

Sensitivity of Types 1 and 2 Herpes Simplex Virus to 5-Iodo-2'-Deoxyuridine and 9-beta-d-Arabinofuranosyladenine.

The sensitivities of 21 strains of herpes simplex virus (HSV), 13 type 1 strains and 8 type 2 strains, to 5-iodo-2'-deoxyuridine (IUdR) and 9-beta-d-arabinofuranosyladenine (ara-A) were evaluated by the plaque-suppression test in chick embryo fibroblast (CEF), WI-38, and HeLa cell cultures. In CEF, type 1 strains were considerably more sensitive to the inhibitors than were the type 2 strains. In WI-38, the type 1 strains were more sensitive than the type 2 strains to IUdR; however, the two serotypes were equally sensitive to ara-A.