1 results match your criteria: "and Massachusetts General Hospital Cancer Center and Harvard Medical School[Affiliation]"
Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis.
Genes Dev
March 2007
Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, and Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston 02114, USA.
Somatic activation of Ras occurs frequently in human cancers, including one-third of lung cancers. Activating Ras mutations also occur in the germline, leading to complex developmental syndromes. The precise mechanism by which Ras activation results in human disease is uncertain.
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