4 results match your criteria: "and Institute of Neuroscience and Medicine (INM-1)[Affiliation]"
Characterisation of age and polarity at onset in bipolar disorder.
Br J Psychiatry
December 2021
Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, USA; Human Genetics, University of California Los Angeles, USA; and Psychiatry, Erasmus University Medical Center, the Netherlands.
Article Synopsis
- The study investigates the genetic and phenotypic traits associated with age at onset (AAO) and polarity at onset (PAO) in bipolar disorder to enhance understanding of the illness and develop screening tools.
- Results indicate that an earlier AAO is linked to more severe symptoms, such as psychosis and suicidality, as well as variations in educational success and living situations.
- The research reveals a significant relationship between higher polygenic risk scores for other mental disorders and earlier AAO, although no significant associations were found for PAO, highlighting considerable variability across different cohorts.
Interplay between the genetics of personality traits, severe psychiatric disorders and COVID-19 host genetics in the susceptibility to SARS-CoV-2 infection.
BJPsych Open
November 2021
Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, University of Munich, Munich, Germany; Department of Psychiatry and Psychotherapy, University Hospital, University of Munich, Munich, Germany; and Institute of Virology, Technical University Munich/Helmholtz Zentrum München, Germany.
Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, with its impact on our way of life, is affecting our experiences and mental health. Notably, individuals with mental disorders have been reported to have a higher risk of contracting SARS-CoV-2. Personality traits could represent an important determinant of preventative health behaviour and, therefore, the risk of contracting the virus.
View Article and Find Full Text PDFSharing the wealth: Neuroimaging data repositories.
Neuroimage
January 2016
Psychology Department & Neuroscience Institute, Georgia State University, Atlanta, GA, USA; Mind Research Network, Albuquerque, NM, USA.
Impact of a cis-associated gene expression SNP on chromosome 20q11.22 on bipolar disorder susceptibility, hippocampal structure and cognitive performance.
Br J Psychiatry
February 2016
Ming Li, PhD, State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China, and Lieber Institute for Brain Development, Johns Hopkins University, Baltimore, Maryland, USA; Xiong-jian Luo, PhD, Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China; Mikael Landén, MD, PhD, Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, and Section of Psychiatry and Neurochemistry, Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden; Sarah E. Bergen, PhD, Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden, and Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA; Christina M. Hultman, PhD, Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden; Xiao Li, MSc, Wen Zhang, PhD, Yong-Gang Yao, PhD, Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China; Chen Zhang, PhD, Schizophrenia Program, Shanghai Mental Health Center, and Shanghai Jiao Tong University School of Medicine, Shanghai, China; Jiewei Liu, MSc, State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, and Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, China; Manuel Mattheisen, MD, Department of Biomedicine, Aarhus University, Aarhus C, Denmark; Sven Cichon, PhD, Division of Medical Genetics, University of Basel, Basel, Switzerland, Institute of Human Genetics and Department of Genomics, Life and Brain Center, University of Bonn, Bonn, and Institute of Neuroscience and Medicine (INM-1), Structural and Functional Organi
Background: Bipolar disorder is a highly heritable polygenic disorder. Recent enrichment analyses suggest that there may be true risk variants for bipolar disorder in the expression quantitative trait loci (eQTL) in the brain.
Aims: We sought to assess the impact of eQTL variants on bipolar disorder risk by combining data from both bipolar disorder genome-wide association studies (GWAS) and brain eQTL.