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Gene replacement-Alzheimer's disease (GR-AD): Modeling the genetics of human dementias in mice.
Alzheimers Dement
April 2024
Laboratory Medicine and Pathology, and Institute for Translational Neuroscience University of Minnesota, Minneapolis, Minnesota, USA.
Article Synopsis
- Genetic studies over the last 40 years have identified key genes linked to Alzheimer's disease and related dementias, but translating these findings into animal models has been challenging.
- The GR-AD project aims to create mouse lines that closely replicate the genetics of Alzheimer's by replacing mouse genes with their human counterparts.
- Each model will include a control line with a normal human allele and variant lines that carry specific harmful mutations or risk variants, allowing for more accurate disease modeling.