2 results match your criteria: "and Hospital Universitario Morales Meseguer[Affiliation]"
Disease-causing mutations in the serpin antithrombin reveal a key domain critical for inhibiting protease activities.
J Biol Chem
October 2017
From the Centro Regional de Hemodonación and Hospital Universitario Morales Meseguer, Universidad de Murcia, Instituto Murciano de Investigación Biosanitaria (IMIB)-Virgen de la Arrixaca, 30003 Murcia, Spain.
Antithrombin mainly inhibits factor Xa and thrombin. The reactive center loop (RCL) is crucial for its interactions with its protease targets and is fully inserted into the A-sheet after its cleavage, causing translocation of the covalently linked protease to the opposite end of the A-sheet. Antithrombin variants with altered RCL hinge residues behave as substrates rather than inhibitors, resulting in stoichiometries of inhibition greater than one.
View Article and Find Full Text PDF[Prevalence of malnutrition and influence of oral nutritional supplementation on nutritional status in institutionalized elderly].
Nutr Hosp
March 2012
Departamento de Fisiología, Universidad de Murcia, and Hospital Universitario Morales Meseguer, Murcia, Spain.
Background: Nutritional supplementation might be an effective strategy for improving the nutritional status and the quality of life of institutionalized fragile elderly.
Objectives: The prevalence of malnutrition and its relation with disease, and the influence of dietary supplementation by means of oral formulas on the nutritional status of elderly nursing home residents were assessed.
Methods: Two studies were carried out, one a cross-sectional survey in 31 subjects and the other a longitudinal-sectional survey in 19 subjects, both groups living in a public nursing home in the city of Murcia (SE Spain).